Preparation, formula optimization and antitumor actions of mannitol coupling camptothecin nanoparticles.

Abstract:

:The purpose of this work is to prepare a formulation using mannitol coupling Camptothecin (CPT) nanoparticles (CPT-NPs) to circumvent the difficult solubilization practice based on central composite experimental statistical design. CPT-NPs were prepared with a high-pressure homogenization technique method. The independent variables considered for the optimization of CPT-NPs were percentage of CPT in raw material (CPT and mannitol), concentration of CPT in working liquid, cycles numbers and homogenizer pressure for drug loading efficiency, particle size and polydispersity index. Analysis of variance (ANOVA) statistical test was used to assess the optimization. The optimized CPT-NPs showed an appropriate drug loading efficiency (18.09 ± 2.13%), a homogeneous particle size (165.33 ± 37.23 nm) and a low polydispersity index (0.29 ± 0.01). The CPT-NPs group show higher inhibition ratio (79.95%) of H22 tumor growth in vivo compared with TPT and CPT at the same dose. Changes in mice body weight demonstrate CPT-NPs have the lower toxicity. The results of biodistribution studies indicated the obviously superiority of CPT-NPs in increasing the accumulation of CPT within tumor. Overall, CPT-NPs under optimum conditions are considered to be potentially feasible to overcome formulation challenges for drug delivery.

journal_name

Int J Pharm

authors

Wang Z,Li Q,Zhao X,Sun B,Zhu Q,Gao W,Hua C

doi

10.1016/j.ijpharm.2014.02.019

subject

Has Abstract

pub_date

2014-04-25 00:00:00

pages

360-7

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(14)00101-X

journal_volume

465

pub_type

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