Abstract：
:Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage forms is a function of their critical coating attributes, including coating thickness, uniformity, and density, more advanced quality control techniques than weight gain are required. A recently introduced non-destructive method to quantitatively characterise coating quality is terahertz pulsed imaging (TPI). The ability of terahertz radiation to penetrate many pharmaceutical materials enables structural features of coated solid dosage forms to be probed at depth, which is not readily achievable with other established imaging techniques, e.g. near-infrared (NIR) and Raman spectroscopy. In this review TPI is introduced and various applications of the technique in pharmaceutical coating analysis are discussed. These include evaluation of coating thickness, uniformity, surface morphology, density, defects and buried structures as well as correlation between TPI measurements and drug release performance, coating process monitoring and scale up. Furthermore, challenges and limitations of the technique are discussed.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Haaser M,Gordon KC,Strachan CJ,Rades Tdoi
10.1016/j.ijpharm.2013.03.053subject
Has Abstractpub_date
2013-12-05 00:00:00pages
510-20issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(13)00283-4journal_volume
457pub_type
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