Abstract：
:This article presents a novel drug release model that combines drug dissolution, diffusion, and immobilization caused by adsorption of the drug to the tablet constituents. Drug dissolution is described by the well-known Noyes-Whitney equation and drug adsorption by a Langmuir-Freundlich adsorption isotherm, and these two processes are included as source and sink terms in the diffusion equation. The model is applicable to tablets that disintegrate into a number of approximately spherical fragments. In order to simplify the analysis it is assumed that liquid absorption, matrix swelling, and tablet disintegration are much faster than drug dissolution and subsequent drug release. The resulting model is shown to yield release characteristics in good agreement with those observed experimentally.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Frenning G,Strømme Mdoi
10.1016/s0378-5173(02)00539-2keywords:
subject
Has Abstractpub_date
2003-01-02 00:00:00pages
137-45issue
1eissn
0378-5173issn
1873-3476pii
S0378517302005392journal_volume
250pub_type
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