WITHDRAWN: Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays.

abstract：:Pharmaceutical containers for parenterals have been predominantly manufactured using glass as a packaging material of choice, especially Type-I glass, since it has been regarded as a chemically inert and an effective container closure system (CCS). Nevertheless, there have been reports and recalls related to glass qua...

journal_title：International journal of pharmaceutics

authors： Srinivasan C,Ma Y,Liu Y,Wang Y,Hengst L,Liu X,Toth R,Rodriguez J,Mohammad A,Bandaranayake BMB,Simon D,Beekman C,Korang-Yeboah M,Sivan S,Lee SL,Cruz CN

更新日期：2019-09-10 00:00:00

abstract：:The formation of extracellular aggregates built up by deposits of β-amyloid (Aβ) is a hallmark of Alzheimer's disease (AD). Curcumin has been reported to display anti-amyloidogenic activity, not only by inhibiting the formation of new Aβ aggregates, but also by disaggregating existing ones. However, the uptake of Curc...

journal_title：International journal of pharmaceutics

authors： Barbara R,Belletti D,Pederzoli F,Masoni M,Keller J,Ballestrazzi A,Vandelli MA,Tosi G,Grabrucker AM

更新日期：2017-06-30 00:00:00

abstract：:Freeze-drying of three different forms of gene delivery systems was performed using a controlled two-step drying process and 10% sucrose as lyoprotectant. Complexes of pCMVL plasmid with transferrin-conjugated polyethylenimine, adenovirus-enhanced transferrinfection consisting of pCMVL/transferrin-polylysine complexes...

journal_title：International journal of pharmaceutics

authors： Talsma H,Cherng J,Lehrmann H,Kursa M,Ogris M,Hennink WE,Cotten M,Wagner E

更新日期：1997-11-28 00:00:00

abstract：:The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consi...

journal_title：International journal of pharmaceutics

authors： Ehlers H,Liu A,Räikkönen H,Hatara J,Antikainen O,Airaksinen S,Heinämäki J,Lou H,Yliruusi J

更新日期：2009-07-30 00:00:00

abstract：:Streamlining the manufacturing process has been recognized as a key issue to reduce production costs and improve safety in pharmaceutical manufacturing. Although data available from earlier developmental stages are often sparse and unstructured, they can be very useful to improve the understanding about the process un...

journal_title：International journal of pharmaceutics

authors： Tomba E,De Martin M,Facco P,Robertson J,Zomer S,Bezzo F,Barolo M

更新日期：2013-02-28 00:00:00

abstract：:The feasibility of a colorimetric technique was investigated in CIELAB color space as an analytical quality control method for content uniformity of printed orodispersible pediatric delivery systems. Inkjet printing was utilized to fabricate orodispersibe film formulations containing propranolol hydrochloride in a col...

journal_title：International journal of pharmaceutics

authors： Vakili H,Nyman JO,Genina N,Preis M,Sandler N

更新日期：2016-09-10 00:00:00

abstract：:This study demonstrates the use of optical coherence tomography (OCT) to simultaneously characterize the roughness of the tablet core and coating of pharmaceutical tablets. OCT is a high resolution non-destructive and contactless imaging methodology to characterize structural properties of solid dosage forms. Besides ...

journal_title：International journal of pharmaceutics

authors： Markl D,Wahl P,Pichler H,Sacher S,Khinast JG

更新日期：2018-01-30 00:00:00

abstract：:Superdisintegrants are a key excipient used in immediate release formulations to promote fast tablet disintegration, therefore understanding the impact of superdisintegrant variability on product performance is important. The current study examined the impact of superdisintegrant critical material attributes (viscosit...

journal_title：International journal of pharmaceutics

authors： Zarmpi P,Flanagan T,Meehan E,Mann J,Fotaki N

更新日期：2020-03-15 00:00:00

abstract：:Despite that in solution we cannot detect the interaction between Ni(2+) and mitoxantrone (MIT), Ni(2+) could mediate effective and stable MIT loading into large unilamellar vesicles (LUVs). The presence of nigericin had almost no influences on MIT encapsulation. However, in the presence of NH(3), the drug loading kin...

journal_title：International journal of pharmaceutics

authors： Cui J,Li C,Wang L,Wang C,Yang H,Li Y,Zhang L,Zhang L,Guo W,Liang M

更新日期：2009-02-23 00:00:00

abstract：:Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2 microm pore size and used as a sterile product...

journal_title：International journal of pharmaceutics

authors： Tsukada Y,Hara K,Bando Y,Huang CC,Kousaka Y,Kawashima Y,Morishita R,Tsujimoto H

更新日期：2009-03-31 00:00:00

abstract：:The electrochemical reduction of ornidazole was studied at a glassy carbon electrode activated by applying a new pretreatment. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the solvent (aqueous media, mixed aqueous-organic systems) and surfactant was investigated. ...

journal_title：International journal of pharmaceutics

authors： Özkan SA,Senturk Z,Biryol I I

更新日期：1997-11-28 00:00:00

abstract：:Fibrous films have attracted considerable attention in the field of drug delivery and wound dressings owing to their porous structure and highly aligned fiber orientation. However, current fabrication methods such as electrospinning have certain limitations, including high voltage requirement and conductivity dependen...

journal_title：International journal of pharmaceutics

authors： Yang Y,Zheng N,Zhou Y,Shan W,Shen J

更新日期：2019-04-05 00:00:00

abstract：:The aim of this study was to investigate if amorphous indomethacin samples, prepared using different preparation methods, exhibit different structural and kinetic characteristics and if these differences can be correlated to their physical stability (time to crystallisation). Samples were prepared by melt quenching, s...

journal_title：International journal of pharmaceutics

authors： Karmwar P,Graeser K,Gordon KC,Strachan CJ,Rades T

更新日期：2011-09-30 00:00:00

abstract：:Poor water solubility, short half-life, and low drug efficacy posed a challenge for clinical application of curcumin (CUR). In this work, a kind of CUR prodrug was synthesized by coupling two CUR molecules with a mono-thioether linker for glutathione (GSH)-responsive drug delivery. The synthesized CUR prodrug (CUR-S-C...

journal_title：International journal of pharmaceutics

authors： Zhang H,Zhang Y,Chen Y,Zhang Y,Wang Y,Zhang Y,Song L,Jiang B,Su G,Li Y,Hou Z

更新日期：2018-10-05 00:00:00

abstract：:Pressure ulcers can form with excess pressure and shearing stress on skin tissue. Because pressure ulcer is often accompanies by exudates, selection of appropriate topical emulsion ointment is difficult. Blended ointments consisting of emulsion base and water-soluble base are clinically used for adjustment of wound mo...

journal_title：International journal of pharmaceutics

authors： Noda Y,Watanabe K,Sanagawa A,Sobajima Y,Fujii S

更新日期：2011-10-31 00:00:00

abstract：:To examine the relative contributions of molecular mobility and thermodynamic factor, the relationship between glass transition temperature (T(g)) and the crystallization rate was examined using amorphous dihydropyridines (nifedipine (NFD), m-nifedipine (m-NFD), nitrendipine (NTR) and nilvadipine (NLV)) with differing...

journal_title：International journal of pharmaceutics

authors： Miyazaki T,Yoshioka S,Aso Y,Kawanishi T

更新日期：2007-05-04 00:00:00

abstract：:Alzheimer's disease (AD) is a common and severe brain disease with a high mortality among the elders, but no highly efficient medications are currently available. For example, timosaponin BII, an efficient anti-AD agent, has low oral bioavailability. Here, timosaponin BII was formulated in a temperature/ion-sensitive ...

journal_title：International journal of pharmaceutics

authors： Chen W,Li R,Zhu S,Ma J,Pang L,Ma B,Du L,Jin Y

更新日期：2020-03-30 00:00:00

abstract：:Stimulated acoustic relaxation emissions from maize starch tablets after compression were detected and recorded in the audible region. Stimulation was found to enhance the detected acoustic emission and to maintain recordable acoustic emission level longer. Based on the fact, that the stimulation by a halogen lamp and...

journal_title：International journal of pharmaceutics

authors： Mellin V,Salonen J,Laine E

更新日期：2001-06-04 00:00:00

abstract：:To evaluate the intestinal permeability of poorly water-soluble compounds, it is of importance to completely dissolve them in a medium and to avoid precipitation during experiments. This study was undertaken to find an agent possessing a high-solubilizing capacity and exhibiting minimal modulating impact on membrane i...

journal_title：International journal of pharmaceutics

authors： Oda M,Saitoh H,Kobayashi M,Aungst BJ

更新日期：2004-08-06 00:00:00

abstract：:A multilayer mat for dispensing colistin sulfate through a body surface was prepared by electrospinning. The fabricated system comprised various polyvinyl alcohol fibrous layers prepared with or without the active ingredient. One of the electrospun layers contained water-soluble colistin sulfate and the other was prep...

journal_title：International journal of pharmaceutics

authors： Sebe I,Ostorházi E,Bodai Z,Eke Z,Szakács J,Kovács NK,Zelkó R

更新日期：2017-05-15 00:00:00

abstract：:Several cationic compounds were screened as potential nasal absorption enhancers to increase intranasal absorption of a model drug, fluorescein isothiocyanate labeled dextran (MW 4.4 kDa, FD-4), without nasal membrane damage in rats. Their effects were compared with those of classical enhancers. Various cationic compo...

journal_title：International journal of pharmaceutics

authors： Natsume H,Iwata S,Ohtake K,Miyamoto M,Yamaguchi M,Hosoya K,Kobayashi D,Sugibayashi K,Morimoto Y

更新日期：1999-08-05 00:00:00

abstract：:The emulsions with various oils such as linseed oil, soybean oil and squalene were prepared to obtain the relationship between the stability and the transfection activity of the emulsions. 1,2-Dioleoyl-sn-glycero-3-trimethylammonium-propane (DOTAP) was used as a single cationic lipid emulsifier. The droplet sizes and ...

journal_title：International journal of pharmaceutics

authors： Kim YJ,Kim TW,Chung H,Kwon IC,Sung HC,Jeong SY

更新日期：2003-02-18 00:00:00

abstract：:The purpose of present study was to assess the enhancing effect of resveratrol (Res) on the absorption of bestatin and clarify the related molecular mechanism. Res facilitated bestatin absorption by down-regulating both protein and gene levels of multidrug resistance 1 (Mdr1) and Multidrug resistance-associated protei...

journal_title：International journal of pharmaceutics

authors： Jia Y,Liu Z,Huo X,Wang C,Meng Q,Liu Q,Sun H,Sun P,Yang X,Shu X,Liu K

更新日期：2015-11-10 00:00:00

abstract：:An innovative approach to improve drug delivery is the use of glycerol monooleate nanoparticles. Numerous studies describe their high versatility, low toxicity and ability to carry relatively high loads of conjugated compounds including scarcely soluble ones, providing sustained drug release and increasing drug diffus...

journal_title：International journal of pharmaceutics

authors： Valente F,Bysell H,Simoni E,Boge L,Eriksson M,Martini A,Astolfi L

更新日期：2018-03-25 00:00:00

abstract：:Poly(ethylene glycol)-conjugated polyethylenimine (PEG-PEI) is a widely studied cationic polymer used to develop non-viral vectors for siRNA therapy of genetic disorders including cancer. Cell lines stably expressing luciferase reporter protein typically evaluate the transfection efficacy of siRNA/PEG-PEI complexes, h...

journal_title：International journal of pharmaceutics

authors： Rheiner S,Reichel D,Rychahou P,Izumi T,Yang HS,Bae Y

更新日期：2017-08-07 00:00:00

abstract：:Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates consisting N-acetyl glucosamine (NAG...

journal_title：International journal of pharmaceutics

authors： Pawar SK,Badhwar AJ,Kharas F,Khandare JJ,Vavia PR

更新日期：2012-10-15 00:00:00

abstract：:The purpose of this study was to develop Pluronic F127 (PF127) based formulations of timolol maleate (TM) aimed at enhancing its ocular bioavailability. The effect of isotonicity agents and PF127 concentrations on the rheological properties of the prepared formulations was examined. In an attempt to reduce the concent...

journal_title：International journal of pharmaceutics

authors： El-Kamel AH

更新日期：2002-07-08 00:00:00

abstract：:The potential of two derivatives of vitamin E, i.e. α-tocopheryl phosphate (TP) and di-α-tocopheryl phosphate (T2P), for the protection and delivery of therapeutics is being investigated in our laboratory and some promising results have been obtained so far. Novel nanocarrier systems containing TP, T2P and different l...

journal_title：International journal of pharmaceutics

authors： Mozafari MR,Javanmard R,Raji M

更新日期：2017-08-07 00:00:00

abstract：:Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The se...

journal_title：International journal of pharmaceutics

authors： Tønnesen HH

更新日期：2001-08-28 00:00:00

abstract：:The objective of this study was to identify key variables affecting the initial release (burst) and the encapsulation of leuprolide acetate-containing poly(lactide-co-glycolide) (PLGA) microparticles, which were prepared by the cosolvent evaporation method. Adjusting parameters, which affected the PLGA precipitation k...

journal_title：International journal of pharmaceutics

authors： Luan X,Skupin M,Siepmann J,Bodmeier R

更新日期：2006-11-06 00:00:00