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The effects of serum on the stability and the transfection activity of the cationic lipid emulsion with various oils.

Abstract：

:The emulsions with various oils such as linseed oil, soybean oil and squalene were prepared to obtain the relationship between the stability and the transfection activity of the emulsions. 1,2-Dioleoyl-sn-glycero-3-trimethylammonium-propane (DOTAP) was used as a single cationic lipid emulsifier. The droplet sizes and size distributions of DOTAP emulsions were dependent on oils which had different interfacial tensions. The droplet sizes followed the order of squalene emulsionsoybean oil emulsion>linseed oil emulsion>DOTAP liposome. The squalene emulsion showed the least cytotoxicity with or without serum. For in vivo gene transfer, the squalene emulsion also had the most potent transfection activity in the mouse after intravenous administration. Squalene as the oil component can enhance the stability of cationic emulsion more effectively that could be useful for the transfer of genes in vitro and in vivo.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Kim YJ,Kim TW,Chung H,Kwon IC,Sung HC,Jeong SY

doi

10.1016/s0378-5173(02)00676-2

keywords:

subject

Has Abstract

pub_date

2003-02-18 00:00:00

pages

241-52

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378517302006762

journal_volume

252

pub_type

杂志文章

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