Abstract：
:A novel dual drug-tailed betaine conjugate amphiphile has been firstly synthesized in which the polar headgroup is derived from glycine betaine and the hydrophobic tails are chlorambucil molecules. The newly prepared conjugate undergoes self-assembly to form stable liposome-like nanocapsules as an effective carrier with high drug loading capacity. The nanocapsules showed higher cytotoxic effects to cancer cell lines than those of free chlorambucil in vitro, and inhibited tumor growth effectively in vivo. This strategy that utilizes new dual drug-tailed betaine conjugate amphiphile to construct a self-assembled nanoparticle drug delivery system may have great potential in cancer chemotherapy.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Fang S,Niu Y,Zhang W,Zhang Y,Yu L,Zhang Y,Li Xdoi
10.1016/j.ijpharm.2015.08.006subject
Has Abstractpub_date
2015-09-30 00:00:00pages
460-5issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30104-6journal_volume
493pub_type
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