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Endothelial progenitor cell secretome delivered by novel polymeric nanoparticles in ischemic hindlimb.

Abstract：

:Endothelial progenitor cells (EPCs) contribute to ischemic tissue repair by paracrine secretion up-regulated by hypoxia. In this study we use novel nanoparticles (NPs) as carriers for a controlled release of EPC secretome (CM) to improve their angiogenic properties. The in vivo effect in ischemic hindlimb rat model was evaluated, comparing hypoxic EPC-CM-NPs with hypoxic EPC-CM alone. A proteomic characterization of hypoxic CM and the in vitro effect on endothelial cells (HUVECs) were also performed. Up to 647 protein, 17 of which with angiogenic properties, were upregulated by hypoxia. Moreover, hypoxic EPC-CM significantly promoted capillary-like structures on Matrigel. A significant increase of blood perfusion in ischemic limbs at 2 weeks with EPC-CM-loaded NPs as compared to both EPC-CM and control and a significant increase of capillary formation were observed. The use of EPC-CM-NPs significantly improved neoangiogenesis in vivo, underlining the advantages of controlled release in regenerative medicine.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Felice F,Piras AM,Rocchiccioli S,Barsotti MC,Santoni T,Pucci A,Burchielli S,Chiellini F,Ucciferri N,Solaro R,Altomare A,Cecchettini A,Di Stefano R

doi

10.1016/j.ijpharm.2018.03.015

subject

Has Abstract

pub_date

2018-05-05 00:00:00

pages

82-89

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30161-3

journal_volume

542

pub_type

杂志文章

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