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Dermal delivery of Fe-chlorophyllin via ultradeformable nanovesicles for photodynamic therapy in melanoma animal model.

Abstract：

:Melanoma is resistant to chemotherapeutics with poor prognosis and high potential of metastasis. Photodynamic therapy (PDT) represents a localized therapeutic modality, as cytotoxicity occurs when light activates photosensitizer (PS) at the tumour site. The aim of this study is dermal delivery of a high molecular weight hydrophilic photosensitizer (PS), ferrous chlorophyllin (Fe-CHL) via transethosomes for treatment of melanoma by PDT. Transethosomes were made of phosphatidyl choline, edge activator and 20% w/v Ethanol. They were evaluated for mean size, zeta potential, entrapment efficiency, ex-vivo permeation, localization in skin layers by transmission electron microscope (TEM), and finally, evaluated in melanoma animal model. Transethosomes of different mean vesicle size were evaluated for their skin retention and permeation through mice skin. TE of ∼500 nm (E3) being ultradeformable showed deep localization in skin confirmed by ex-vivo and TEM micrographs without permeation of PS to recipient compartment due to its size. The proposed study offers successful treatment of resistant melanoma by PDT, where complete tumour regression of small tumours occurred after single PDT, while large tumours after double PDT without recurrence for 8 months. This indicates the efficiency of nanovesicles in PS delivery and the efficiency of Fe-CHL in production of reactive oxygen species.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Rady M,Gomaa I,Afifi N,Abdel-Kader M

doi

10.1016/j.ijpharm.2018.06.057

subject

Has Abstract

pub_date

2018-09-05 00:00:00

pages

480-490

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30456-3

journal_volume

548

pub_type

杂志文章

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