Abstract:
:Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2 microm pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts. (1) Increase stirring rate of poor solvent. (2) Decrease feed rate of good solvent. (3) Increase poor solvent ratio. (4) Increase the temperature of poor solvent. (5) Decrease polyvinyl alcohol concentration in poor solvent. (6) Increase ethanol concentration in good solvent. (7) Decrease PLGA concentration in good solvent. After optimization, PLGA nanospheres with a mean particle size of 102-163 nm and the 100-98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tsukada Y,Hara K,Bando Y,Huang CC,Kousaka Y,Kawashima Y,Morishita R,Tsujimoto Hdoi
10.1016/j.ijpharm.2008.11.019subject
Has Abstractpub_date
2009-03-31 00:00:00pages
196-201issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(08)00790-4journal_volume
370pub_type
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