The stimulated acoustic relaxation emission of maize starch tablets.

abstract：:Topical formulations aim to target the skin for a variety of cosmetic, protective or therapeutic needs. Despite the use of creams and ointments over the millennia, the bioavailability of actives from topical preparations remains quite low, often not exceeding 1-2% of the applied dose. In this review we examine the rea...

journal_title：International journal of pharmaceutics

authors： Hadgraft J,Lane ME

更新日期：2016-11-30 00:00:00

abstract：:Oxidative stress has been implicated in the progression of age-related macular degeneration (AMD). Treatment with antioxidants seems to delay progression of AMD. In this study, we suggested an antioxidant delivery system based on redox-sensitive liposome composed of phospholipids and a diselenide centered alkyl chain....

journal_title：International journal of pharmaceutics

authors： Behroozi F,Abdkhodaie MJ,Abandansari HS,Satarian L,Ashtiani MK,Jaafari MR,Baharvand H

更新日期：2018-09-05 00:00:00

abstract：:Polyurethane polymers and poly(ether urethane) copolymers were chosen as drug carriers for alpha-tocopherol. This active ingredient is widely used as a strong antioxidant in many medical and cosmetic applications, but is rapidly degraded, because of its light, heat and oxygen sensitivity. Polyurethane and poly(ether u...

journal_title：International journal of pharmaceutics

authors： Bouchemal K,Briançon S,Perrier E,Fessi H,Bonnet I,Zydowicz N

更新日期：2004-01-09 00:00:00

abstract：:A series of thermoresponsive-co-biodegradable polymers, containing varying molar ratios of N-isopropylacrylamide (NIPA) and poly-lactic acid diacrylate macromer (PLAM) were prepared and characterised. Chemical structures were confirmed by nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR). The hydr...

journal_title：International journal of pharmaceutics

authors： Chearúil FN,Corrigan OI

更新日期：2009-01-21 00:00:00

abstract：:Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features o...

journal_title：International journal of pharmaceutics

authors： Radmanesh F,Abandansari HS,Pahlavan S,Alikhani M,Karimi M,Rajabi S,Kazemi B,Baharvand H

更新日期：2019-06-30 00:00:00

abstract：:The purpose of this research was to study isomalt as a protein-stabilizing excipient with lactate dehydrogenase (LDH) during freeze-drying and subsequent storage and compare it to sucrose, a standard freeze-drying excipient. Four different diastereomer mixtures of isomalt were studied. The stability of the protein was...

journal_title：International journal of pharmaceutics

authors： Tuderman AK,Strachan CJ,Juppo AM

更新日期：2018-03-01 00:00:00

abstract：:This work investigates the impact of vaginal ring size and drug loading on the in vitro release, safety, ease of fit, and pharmacokinetics in cynomolgus macaques of matrix-type silicone elastomer vaginal rings containing a combination of the non-nucleoside reverse transcriptase inhibitor dapivirine and the protease in...

journal_title：International journal of pharmaceutics

authors： Murphy DJ,Desjardins D,Boyd P,Dereuddre-Bosquet N,Stimmer L,Caldwell A,Le Grand R,Kelly C,van Roey J,Malcolm RK

更新日期：2018-10-25 00:00:00

abstract：:The purpose of this study was to investigate the use of 6-carboxycellulose (OC), a biocompatible and bioresorbable polymer, as a prodrug carrier for amine drugs. Phenylpropanolamine hydrochloride (PPA.HCl) was used as a model drug. OC and PPA were reacted in dimethylformamide (DMF) in the presence of 1,3-dicyclohexylc...

journal_title：International journal of pharmaceutics

authors： Zhu L,Kumar V,Banker GS

更新日期：2001-07-31 00:00:00

abstract：:The use of nanomedicines to induce immunogenic cell death is a new strategy that aims to increase tumor immunogenicity and thereby prime tumors for further immunotherapies. In this study, we developed a nanoparticle formulation for combinatory chemotherapy and photothermal therapy based only on materials previously us...

journal_title：International journal of pharmaceutics

authors： Heshmati Aghda N,Abdulsahib SM,Severson C,Lara EJ,Torres Hurtado S,Yildiz T,Castillo JA,Tunnell JW,Betancourt T

更新日期：2020-09-06 00:00:00

abstract：:Once introduced into physiological environment, nanoparticles (NPs) are immediately coated with proteins, resulting in formation of what is known as protein corona. The formation of protein corona can be affected by many factors. Likewise, the addition of protein corona can alter the physicochemical properties and bio...

journal_title：International journal of pharmaceutics

authors： Xiao W,Gao H

更新日期：2018-12-01 00:00:00

abstract：:Clonazepam and lorazepam are two anxiolytics, antidepressant agents, having suitable features for transdermal delivery. The objectives of this study were to evaluate the in vitro percutaneous absorption of these drugs through excised human skin (stratum corneum and epidermis, SCE) and to determine their in vitro perme...

journal_title：International journal of pharmaceutics

authors： Puglia C,Bonina F,Trapani G,Franco M,Ricci M

更新日期：2001-10-09 00:00:00

abstract：:Docetaxel (DTX) is one of the important antitumor drugs, being used in several common chemotherapies to control leading cancer types. Severe toxicities of the DTX are prominent due to sudden parenteral exposure of desired loading dose to maintain the therapeutic concentration. Field of nanotechnology is leading to res...

journal_title：International journal of pharmaceutics

authors： Choudhury H,Gorain B,Pandey M,Kumbhar SA,Tekade RK,Iyer AK,Kesharwani P

更新日期：2017-08-30 00:00:00

abstract：:Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the perf...

journal_title：International journal of pharmaceutics

authors： Frant M,Dayyoub E,Bakowsky U,Liefeith K

更新日期：2018-07-30 00:00:00

abstract：:Since the last decade, nanodispersed drug delivery systems gain increasingly more importance for therapeutic research fields. The forced transport to the centers of inflammation is supposed to take advantage as a novel strategic approach. Thus, the focus of this study was to investigate the applicability of ubiquinone...

journal_title：International journal of pharmaceutics

authors： Hoennscheidt C,Margaritis A,Krull R

更新日期：2015-01-15 00:00:00

abstract：:The purpose of this study was to develop solid dispersions of fenretinide(4HPR), incorporate them into poly(lactic-co-glycolic)(PLGA) millicylindrical implants, and evaluate the resulting implants in vitro and in vivo for future applications in oral cancer chemoprevention. Due to the extreme hydrophobicity of 4HPR, 4H...

journal_title：International journal of pharmaceutics

authors： Nieto K,Mallery SR,Schwendeman SP

更新日期：2020-08-30 00:00:00

abstract：:Camphor (CA) encapsulation in oil/water/oil multiple emulsions prepared with cyclodextrin disturbs the emulsifier potential of alpha- and beta-natural cyclodextrins (CD). It was suggested that the size and geometrical fit between the CD cavity and CA could induce CD/CA complex formation in place of emulsifier formatio...

journal_title：International journal of pharmaceutics

authors： Yu SC,Bochot A,Bas GL,Chéron M,Mahuteau J,Grossiord JL,Seiller M,Duchêne D

更新日期：2003-08-11 00:00:00

abstract：:The objective of this study was to gain insights into the structural integrity of PLGA during an ammonolysis-based microencapsulation process. PLGA (lactide:glycolide ratio=75:25; M(w)=25,925 g/mol) was dissolved in ethyl acetate or isopropyl formate (3-6 ml), which was emulsified in an aqueous phase. Ammonia, being a...

journal_title：International journal of pharmaceutics

authors： Heo S,Lee M,Lee S,Sah H

更新日期：2011-10-31 00:00:00

abstract：:RNA interfere (RNAi)-based technology holds great promise in cancer treatment. The use of small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo when they are diluted in blood biofluids and in the presence of serum and salt. In this study, we developed the polyglutamate derivative p...

journal_title：International journal of pharmaceutics

authors： Wang Z,Zou H,Wang Z,Wu J,Xia Z,Feng M

更新日期：2016-05-30 00:00:00

abstract：:Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffractio...

journal_title：International journal of pharmaceutics

authors： Lu Z,Yang Y,Covington RA,Bi YV,Dürig T,Ilies MA,Fassihi R

更新日期：2016-09-25 00:00:00

abstract：:Cyclodextrin-based nanosponges (CD-NSs) are insoluble, highly cross-linked 3D network polymers used in several scientific and technological fields, the main area of investigation concerns the pharmaceutical applications, in which CD-NSs have been mostly employed as drug delivery systems. CD-NSs can be generally groupe...

journal_title：International journal of pharmaceutics

authors： Caldera F,Tannous M,Cavalli R,Zanetti M,Trotta F

更新日期：2017-10-15 00:00:00

abstract：:Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug losses in the mouth-throat region. Aerosol efficiency of DPIs is closely related to...

journal_title：International journal of pharmaceutics

authors： Dos Reis LG,Chaugule V,Fletcher DF,Young PM,Traini D,Soria J

更新日期：2021-01-05 00:00:00

abstract：:Although the taste-masking of bitter drug using ion exchange resin has been recognized, in vitro testing using an electronic tongue (e-Tongue) and in vivo bitterness test by human panel test was not fully understood. In case of orally disintegrating tablet (ODT) containing bitter medicine, in vitro and in vivo disinte...

journal_title：International journal of pharmaceutics

authors： Kim JI,Cho SM,Cui JH,Cao QR,Oh E,Lee BJ

更新日期：2013-10-15 00:00:00

abstract：:Inhalable dry-powder aggregates of drug-loaded thermally sensitive poly(caprolactone) (PCL) nanoparticles are produced using spray-freeze-drying (SFD) as the low melting point of PCL prohibits the use of high-temperature spray-drying. The effects of freeze-drying adjuvant formulation on the particle morphology, aerody...

journal_title：International journal of pharmaceutics

authors： Cheow WS,Ng ML,Kho K,Hadinoto K

更新日期：2011-02-14 00:00:00

abstract：:Gravimetric water sorption experiments were performed to study the crystallization behavior of amorphous spray-dried lactose over a wide range of temperature and humidity conditions. Experiments performed at 25 degrees C between 48 and 60% relative humidity (RH) showed that the onset time to crystallization increased ...

journal_title：International journal of pharmaceutics

authors： Burnett DJ,Thielmann F,Sokoloski T,Brum J

更新日期：2006-04-26 00:00:00

abstract：:Polysaccharide-coated liposomes have been studied for their potential use for peptide drug delivery by the oral route because they are able to minimize the disruptive influences on peptide drugs of gastrointestinal fluids. The aim of this work was to synthesize and characterize a modified polysaccharide, O-palmitoylsc...

journal_title：International journal of pharmaceutics

authors： Carafa M,Marianecci C,Annibaldi V,Di Stefano A,Sozio P,Santucci E

更新日期：2006-11-15 00:00:00

abstract：:This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/vancomycin/gentamicin/lidocaine were separately di...

journal_title：International journal of pharmaceutics

authors： Chen DW,Hsu YH,Liao JY,Liu SJ,Chen JK,Ueng SW

更新日期：2012-07-01 00:00:00

abstract：:Poly[lactic-co-glycolide] (PLGA) nanoparticles, chitosan-dextran sulphate microparticles, and DOTAP-liposomes were prepared as vaccine adjuvants and drug carriers for a small hydrophilic model peptide, and their different physico-chemical properties (size, PDI, zeta-potential, pH-value and peptide loading) were invest...

journal_title：International journal of pharmaceutics

authors： Wieber A,Selzer T,Kreuter J

更新日期：2011-12-12 00:00:00

abstract：:The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp) through excised porci...

journal_title：International journal of pharmaceutics

authors： Mura P,Orlandini S,Cirri M,Maestrelli F,Mennini N,Casella G,Furlanetto S

更新日期：2018-08-25 00:00:00

abstract：:This study systematically demonstrated the antigenicity kinetics of HBV vaccine microneedles (MNs) during the fabrication, application and storage. To improve the stability of HBsAg in a microneedle patch, several selected saccharides were added to the MN formulations as stabilizers. According to the experimental data...

journal_title：International journal of pharmaceutics

authors： Zhu DD,Zhang XP,Yu HL,Liu RX,Shen CB,Zhang WF,Cui Y,Guo XD

更新日期：2019-08-15 00:00:00

abstract：:This study aimed to develop an evaluation approach for supersaturation by employing an in vitro bio-mimicking apparatus designed to predict in vivo performance. The Biphasic Gastrointestinal Simulator (BGIS) is composed of three chambers with absorption phases that represent the stomach, duodenum, and jejunum, respect...

journal_title：International journal of pharmaceutics

authors： Gan Y,Zhang X,Xu D,Zhang H,Baak JP,Luo L,Xia Y,Wang J,Ke X,Sun P

更新日期：2020-03-30 00:00:00