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Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model.

Abstract：

:Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the performance of biomaterials prior to performing delicate and expensive in vivo studies. In this study we present a complex BioEncrustation model that imitates both the processes of multi-species biofilm formation and encrustation in vitro. The resulting crystalline biofilms are compared to the deposits found on explanted ureteral stent surfaces (in vivo situation) and to deposits formed in an experimental set up that does not contain bacteria (Encrustator®). Further focus of this study is dedicated to employing the developed BioEncrustation model to evaluate the effect multifunctional coatings impose on the processes of biofilm formation and encrustation under in vitro conditions. The investigated TANP coating combines unspecific and broad band specific antibacterial properties with a degrading polymer matrix that is intended to inhibit crystal formation. The coating was prepared on both polyurethane and silicone tubes and the subsequent results of the in vitro BioEncrustation analyses reveal a promising potential for employing the coating to render ureteral stent surfaces more biocompatible.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Frant M,Dayyoub E,Bakowsky U,Liefeith K

doi

10.1016/j.ijpharm.2018.04.023

subject

Has Abstract

pub_date

2018-07-30 00:00:00

pages

86-96

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30240-0

journal_volume

546

pub_type

杂志文章

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