Abstract:
:Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear force application. Moreover, data obtained from the shear method depend on the orientation of the bilayer tablet. Although more time-consuming to perform, the tensile method yields data that are straightforward to interpret. Thus, the tensile method is preferred in fundamental bilayer tableting research to minimize ambiguity in data interpretation. Using both shear and tensile methods, we measured the mechanical strength of bilayer tablets made of several different layer combinations of lactose and microcrystalline cellulose. We observed a good correlation between strength obtained by the tensile method and carefully conducted shear method. This suggests that the shear method may be used for routine quality test of bilayer tablets during manufacturing because of its speed and convenience, provided a protocol for careful control of the placement of the tablet interface, tablet orientation, and blade is implemented.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Chang SY,Li JX,Sun CCdoi
10.1016/j.ijpharm.2017.03.010subject
Has Abstractpub_date
2017-05-15 00:00:00pages
121-126issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30177-1journal_volume
523pub_type
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