Abstract：
:Despite the great advances accomplished in the treatment of pediatric cancers, recurrences and metastases still exacerbate prognosis in some aggressive solid tumors such as neuroblastoma and osteosarcoma. In view of the poor efficacy and toxicity of current chemotherapeutic treatments, we propose a single multitherapeutic nanotechnology-based strategy by co-assembling in the same nanodevice two amphiphilic antitumor agents: squalenoyl-gemcitabine and edelfosine. Homogeneous batches of nanoassemblies were easily formulated by the nanoprecipitation method. Their anticancer activity was tested in pediatric cancer cell lines and pharmacokinetic studies were performed in mice. In vitro assays revealed a synergistic effect when gemcitabine was co-administered with edelfosine. Squalenoyl-gemcitabine/edelfosine nanoassemblies were found to be capable of intracellular translocation in patient-derived metastatic pediatric osteosarcoma cells and showed a better antitumor profile than squalenoyl-gemcitabine nanoassemblies alone. The intravenous administration of this combinatorial nanomedicine in mice exhibited a controlled release behavior of gemcitabine and diminished edelfosine plasma peak concentrations. These findings make it a suitable pre-clinical candidate for childhood cancer therapy.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Rodríguez-Nogales C,Mura S,Couvreur P,Blanco-Prieto MJdoi
10.1016/j.ijpharm.2020.119345subject
Has Abstractpub_date
2020-05-30 00:00:00pages
119345eissn
0378-5173issn
1873-3476pii
S0378-5173(20)30329-Xjournal_volume
582pub_type
杂志文章abstract：:A comprehensive model is proposed to accurately describe drug release kinetics from a coated plane sheet when drug loading in the core is above its saturation level. The general solutions are acquired in a dimensionless form by the Laplace transform and the solution for the special case-a perfect sink condition, is de...
journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-09-15 00:00:00
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doi：10.1016/s0378-5173(02)00546-x
更新日期：2003-01-02 00:00:00
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pub_type： 杂志文章
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更新日期：2002-07-25 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.ijpharm.2014.02.040
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pub_type： 杂志文章
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更新日期：1999-03-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2006-08-17 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-03-23 00:00:00
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pub_type： 杂志文章
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更新日期：2019-07-20 00:00:00
