当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Comparison of the IV pharmacokinetics in sheep of miconazole-cyclodextrin solutions and a micellar solution.

Comparison of the IV pharmacokinetics in sheep of miconazole-cyclodextrin solutions and a micellar solution.

Abstract：

:The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV(R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-betaCD or 50 mM SBE7-betaCD). The aim of this work was to demonstrate that these cyclodextrin derivatives (CDs) have no effect on the pharmacokinetics of miconazole by comparison with the micellar solution. The plasma concentration time curves have shown that there is no significant difference between the three solutions.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Piel G,Evrard B,Van Hees T,Delattre L

doi

10.1016/s0378-5173(98)00403-7

keywords:

subject

Has Abstract

pub_date

1999-03-25 00:00:00

pages

41-5

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(98)00403-7

journal_volume

180

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Formulation, stability and degradation kinetics of intravenous cinnarizine lipid emulsion.

    abstract：:Cinnarizine was loaded in the lipid emulsion to develop an intravenous formulation with good physical and chemical stability. High-pressure homogenization was used to prepare the lipid emulsion. The factors influencing the stability of cinnarizine lipid emulsion, such as different drug loading methods, pH, temperature...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.02.006

    authors： Shi S,Chen H,Cui Y,Tang X

    更新日期：2009-05-21 00:00:00

  • In-line monitoring of partial and overall solid concentration during solvent-mediated phase transition using Raman spectroscopy.

    abstract：:A calibration strategy for the continuous monitoring of solvent-mediated phase transition was developed using in situ Raman spectroscopy. Citric acid which exhibits enantiotropy during its anhydrous/monohydrate phase transition was selected as a model organic product. Using 25 samples in suspension, specific calibrati...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.10.009

    authors： Caillet A,Puel F,Fevotte G

    更新日期：2006-01-13 00:00:00

  • Enzymatic characterization of lipid-based drug delivery systems.

    abstract：:The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.02.038

    authors： Ljusberg-Wahren H,Seier Nielsen F,Brogård M,Troedsson E,Müllertz A

    更新日期：2005-07-25 00:00:00

  • A substrate pharmacophore for the human sodium taurocholate co-transporting polypeptide.

    abstract：:Human sodium taurocholate co-transporting polypeptide (NTCP) is the main bile acid uptake transporter in the liver with the capability to translocate xenobiotics. While its inhibitor requirements have been recently characterized, its substrate requirements have not. The objectives of this study were (a) to elucidate N...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.11.022

    authors： Dong Z,Ekins S,Polli JE

    更新日期：2015-01-15 00:00:00

  • Comparison of different zeolite framework types as carriers for the oral delivery of the poorly soluble drug indomethacin.

    abstract：:Microporous zeolites of distinct framework types, textural properties and crystal morphologies namely BEA, ZSM and NaX, have been employed as carriers to assess their effect on modulating the dissolution behavior of a BCS II model drug (indomethacin). Preparation of the loaded carriers via the incipient wetness method...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.061

    authors： Karavasili C,Amanatiadou EP,Kontogiannidou E,Eleftheriadis GK,Bouropoulos N,Pavlidou E,Kontopoulou I,Vizirianakis IS,Fatouros DG

    更新日期：2017-08-07 00:00:00

  • Enhancing the solubility and permeability of the diuretic drug furosemide via multicomponent crystal forms.

    abstract：:Furosemide (FSM) is a biopharmaceutical classification system (BCS) class IV drug, being a potent loop diuretic used in the treatment of congestive heart failure and edema. Due to its low solubility and permeability, FSM is known for exhibiting poor oral bioavailability. In order to overcome or even minimize these und...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119694

    authors： Diniz LF,Carvalho PS Jr,Pena SAC,Gonçalves JE,Souza MAC,de Souza Filho JD,Bomfim Filho LFO,Franco CHJ,Diniz R,Fernandes C

    更新日期：2020-09-25 00:00:00

  • Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.

    abstract：:Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid the acidic conversion of lovastatin to its hydroxyacid derivative. In a two-step process, sucrose beads were layered with a glass solution of ezetimibe, lovastatin and Soluplus®, top-coated with an ent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.01.053

    authors： Riekes MK,Dereymaker A,Berben P,Augustijns P,Stulzer HK,Van den Mooter G

    更新日期：2017-03-30 00:00:00

  • Investigation of physicochemical factors affecting the stability of a pH-modulated solid dispersion and a tablet during storage.

    abstract：:The stability of solid dispersions (SD) during storage is of concern. We prepared the pH-modulated SD (pSD) and compressed tablets consisting of polyethylene glycol (PEG) 6000 as a carrier, drug and MgO (alkalizer). Telmisartan (TEL), an ionizable poorly water-soluble drug, was chosen as a model drug. The changes in p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.04.065

    authors： Tran PH,Tran TT,Park JB,Min DH,Choi HG,Han HK,Rhee YS,Lee BJ

    更新日期：2011-07-29 00:00:00

  • CombiCap: A novel drug formulation for the basel phenotyping cocktail.

    abstract：:Phenotyping of cytochrome P450 isoenzymes is used for metabolic profiling. Phenotyping cocktails are usually administered as individual marketed products, which are not designed for diagnostic applications. Therefore, a formulation strategy was developed, which can be applied to any phenotyping cocktail. The formulati...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.043

    authors： Camblin M,Berger B,Haschke M,Krähenbühl S,Huwyler J,Puchkov M

    更新日期：2016-10-15 00:00:00

  • Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency.

    abstract：:Lipid-Polycation-DNA complexes (LPD) is a promising non-viral system for nucleic acids delivery. Usually, LPD are prepared just before their use. In the present work, we have examined whether dehydration of a new type of LPD (named LPD100) might be a storage option. LPD100 comprises PEGylated histidylated polylysine/p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.04.009

    authors： Perche F,Lambert O,Berchel M,Jaffrès PA,Pichon C,Midoux P

    更新日期：2012-02-14 00:00:00

  • Dehydration of trehalose dihydrate at low relative humidity and ambient temperature.

    abstract：:The physico-chemical behaviour of trehalose dihydrate during storage at low relative humidity and ambient temperature was investigated, using a combination of techniques commonly employed in pharmaceutical research. Weight loss, water content determinations, differential scanning calorimetry and X-ray powder diffracti...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.01.026

    authors： Jones MD,Hooton JC,Dawson ML,Ferrie AR,Price R

    更新日期：2006-04-26 00:00:00

  • Tablet capping predictions of model materials using multivariate approach.

    abstract：:The present study demonstrated the prediction of predominant root causes of capping behavior as a function of the powder rheological and the mechanical behavior of Acetaminophen (APAP) and Ibuprofen (IBU). The authors analyzed powder rheological properties for powder blend permeability, pressure drop, and cohesion. Th...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118548

    authors： Basim P,Haware RV,Dave RH

    更新日期：2019-10-05 00:00:00

  • Human erythrocytes are affected in vitro by flavonoids of Aristotelia chilensis (Maqui) leaves.

    abstract：:Aristotelia chilensis (Mol.) Stuntz (A. chilensis), also known as maqui, is a plant of the Elaeocarpaceae family that grows in central and southern Chile as well as southwestern Argentina. Infusions of its leaves have long been used in the traditional native herbal medicine to treat different ailments. Phytochemical s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.07.005

    authors： Suwalsky M,Vargas P,Avello M,Villena F,Sotomayor CP

    更新日期：2008-11-03 00:00:00

  • Poly(ethylene glycol) layered silicate nanocomposites for retarded drug release prepared by hot-melt extrusion.

    abstract：:Composites of paracetamol loaded poly(ethylene glycol) (PEG) with a naturally derived and partially synthetic layered silicate (nanoclay) were prepared using hot-melt extrusion. The extent of dispersion and distribution of the paracetamol and nanoclay in the PEG matrix was examined using a combination of field emissio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.06.027

    authors： Campbell K,Craig DQ,McNally T

    更新日期：2008-11-03 00:00:00

  • Evaluation of the vibratory feeder method for assessment of powder flow properties.

    abstract：:The flow properties of pharmaceutical powders and blends used in solid oral dosage forms are an important consideration during dosage form development. The vibratory feeder method, a flow measurement technique that quantifies avalanche flow, has been adapted for measurement of the flow properties of common pharmaceuti...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.09.024

    authors： Bhattachar SN,Hedden DB,Olsofsky AM,Qu X,Hsieh WY,Canter KG

    更新日期：2004-01-28 00:00:00

  • Comparison of two hard keratinous substrates submitted to the action of a keratinase using an experimental design.

    abstract：:The influence of temperature, pH, keratinase concentration, substrate concentration and incubation time on the soluble proteins released by a new keratinase from Doratomyces microsporus was studied with a second-order experimental design. Only 15 or 18 spectrophotometric analyses were required to determine the optimal...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00749-9

    authors： Vignardet C,Guillaume YC,Michel L,Friedrich J,Millet J

    更新日期：2001-08-14 00:00:00

  • Melt extrusion with poorly soluble drugs - An integrated review.

    abstract：:Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This revie...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.10.056

    authors： Repka MA,Bandari S,Kallakunta VR,Vo AQ,McFall H,Pimparade MB,Bhagurkar AM

    更新日期：2018-01-15 00:00:00

  • Polymorphs and pharmacokinetics of an antipsychotic drug candidate.

    abstract：:A potent antipsychotic drug candidate, 7-(4-(4-(6-fluorobenzo[d]-isoxazol-3-yl)-piperidin-1-yl)butoxy)-4-methyl-8-chloro -2H-chromen-2-one mesylate(CY611), with good in vitro and in vivo antipsychotic effects was investigated for preformulation evaluation by crystallography methods. Three anhydrous polymorphs(Form I-I...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119600

    authors： Hao C,Chen Y,Xiong J,Yang Z,Gao L,Liu BF,Liu X,Jin J,Zhang G

    更新日期：2020-08-30 00:00:00

  • Development of a new method to characterize (SMBV) antigen formulations using surface plasmon resonance technology.

    abstract：:Supra Molecular Biovectors (SMBV) are nanoparticles composed by a polysaccharidic core surrounded by a lipid bilayer. They are designed for drug delivery and vaccine and can be administrated by nasal route. The association rate and the stability of association between active principle (AP) or antigens (Ag) with SMBV c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00227-2

    authors： Siguier JP,Major M,Balland O

    更新日期：2002-08-21 00:00:00

  • Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate.

    abstract：:Preparation of oil-in-water (o/w) type lipid emulsion is one of the approaches to formulate drugs that are poorly water-soluble but can be dissolved in the oil phase of the emulsions. A synthetic glucocorticoid medicine, difluprednate (DFBA), is a water-insoluble compound. We formulated DFBA (0.05%, w/v) ophthalmic li...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.036

    authors： Yamaguchi M,Yasueda S,Isowaki A,Yamamoto M,Kimura M,Inada K,Ohtori A

    更新日期：2005-09-14 00:00:00

  • Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses.

    abstract：:Designing strategies for targeting antigens to dendritic cells is a major goal in vaccinology. Here, PLGA (poly lactic-co-glycolic acid) microspheres and with several surface modifications that affect to their uptake by human blood primary dendritic cells and monocytes have been evaluated. Higher uptake was found by a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.037

    authors： Salvador A,Sandgren KJ,Liang F,Thompson EA,Koup RA,Pedraz JL,Hernandez RM,Loré K,Igartua M

    更新日期：2015-12-30 00:00:00

  • Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng.

    abstract：:The purpose of this research is to evaluate the effect of self-micelle formation and incorporation of lipid in the formulation on absorption of ginsenosides Rg1 and Rb1 from intestinal tract in rats. Ginsenosides Rg1 and Rb1 were extracted from Panax notoginseng saponins (PNS). The critical micellar concentration (CMC...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.04.016

    authors： Xiong J,Guo J,Huang L,Meng B,Ping Q

    更新日期：2008-08-06 00:00:00

  • A single-layer film coating for colon-targeted oral delivery.

    abstract：:Most pH-sensitive polymer coating studies for potential colonic delivery systems apply multiple layers to protect the active agent from degradation and early release in the stomach and small intestine. This study designed a single-coat pH-sensitive layer for colon-specific delivery with a potential biopolymer, namely,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.066

    authors： Nguyen MNU,Tran PHL,Tran TTD

    更新日期：2019-03-25 00:00:00

  • Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor.

    abstract：:It is well acknowledged that oral bioavailability of a drug candidate is often influenced by factors such as the permeability, physico-chemical properties, and metabolism of the drug. Among the physico-chemical properties, solubility and dissolution rate are considered the most critical factors affecting the oral bioa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.06.064

    authors： Cui Y,Chiang PC,Choo EF,Boggs J,Rudolph J,Grina J,Wenglowsky S,Ran Y

    更新日期：2013-09-15 00:00:00

  • Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution.

    abstract：:Amorphous nanoparticle suspensions of a poorly water-soluble drug, cyclosporine A, are produced by a new process, evaporative precipitation into aqueous solution (EPAS). The rapid evaporation of a heated organic solution of the drug, which is atomized into an aqueous solution, results in fast nucleation leading to nan...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00147-3

    authors： Chen X,Young TJ,Sarkari M,Williams RO 3rd,Johnston KP

    更新日期：2002-08-21 00:00:00

  • Multifunctional TK-VLPs nanocarrier for tumor-targeted delivery.

    abstract：:Virus-like particles (VLPs) have been exploited for various biomedical applications, such as the monitoring, prevention, diagnosis and therapy of disease. In this study, a novel multifunctional VLPs nanocarrier (TK-VLPs) was prepared and used for tumor-targeted delivery. The SPR and cell uptake results indicated that ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.02.037

    authors： Ren Y,Mu Y,Jiang L,Yu H,Yang S,Zhang Y,Wang J,Zhang H,Sun H,Xiao C,Peng H,Zhou Y,Lu W

    更新日期：2016-04-11 00:00:00

  • Enhanced anti-tumor and anti-metastasis therapy for triple negative breast cancer by CD44 receptor-targeted hybrid self-delivery micelles.

    abstract：:Tumor growth and metastasis are multistep processes regulated by multiple signaling pathways. The successful treatment of cancer largely depends on the ability to inhibit metastatic process. Multiphase inhibition of metastasis is a promising approach. Here, we described a targeting delivery system which was constructe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119085

    authors： Yang Y,Long Y,Wang Y,Ren K,Li M,Zhang Z,Xiang B,He Q

    更新日期：2020-03-15 00:00:00

  • Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery--a pilot study.

    abstract：:Semifluorinated alkanes (SFAs) have been described as potential excipients for pulmonary drug delivery, but proof of their efficacy is still lacking. We tested whether SFA formulations with the test drug ibuprofen can be nebulised and evaluated their pharmacokinetics. Physico-chemical properties of five different ibup...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.10.051

    authors： Tsagogiorgas C,Jung T,Krebs J,Theisinger B,Beck G,Yard BA,Quintel M

    更新日期：2012-01-17 00:00:00

  • An approach for chemical stability during melt extrusion of a drug substance with a high melting point.

    abstract：:Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.03.070

    authors： Haser A,Huang S,Listro T,White D,Zhang F

    更新日期：2017-05-30 00:00:00

  • Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

    abstract：:The purpose of this study was to investigate the formation mechanism of colloidal nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture (GM) into water. Probucol, PVP and SDS were mixed at a weight ratio of 1:3:1 and ground for 30 min with a vibratio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.10.052

    authors： Pongpeerapat A,Wanawongthai C,Tozuka Y,Moribe K,Yamamoto K

    更新日期：2008-03-20 00:00:00