Abstract:
:The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV(R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-betaCD or 50 mM SBE7-betaCD). The aim of this work was to demonstrate that these cyclodextrin derivatives (CDs) have no effect on the pharmacokinetics of miconazole by comparison with the micellar solution. The plasma concentration time curves have shown that there is no significant difference between the three solutions.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Piel G,Evrard B,Van Hees T,Delattre Ldoi
10.1016/s0378-5173(98)00403-7keywords:
subject
Has Abstractpub_date
1999-03-25 00:00:00pages
41-5issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(98)00403-7journal_volume
180pub_type
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