当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Investigation on structural integrity of PLGA during ammonolysis-based microencapsulation process.

Investigation on structural integrity of PLGA during ammonolysis-based microencapsulation process.

Abstract：

:The objective of this study was to gain insights into the structural integrity of PLGA during an ammonolysis-based microencapsulation process. PLGA (lactide:glycolide ratio=75:25; M(w)=25,925 g/mol) was dissolved in ethyl acetate or isopropyl formate (3-6 ml), which was emulsified in an aqueous phase. Ammonia, being added to the emulsions, reacted with the dispersed solvents to yield water-miscible solvents. Consequently, emulsion droplets were solidified into microspheres. To evaluate the impact of ammonia upon PLGA, the molar ratio of ammonia to a dispersed solvent varied from 1 to 2 and 3. After preparation of microspheres by the ammonolysis-based procedure, the lactide:glycolide composition and Mw of PLGA were analyzed by (1)H NMR and GPC. Our results demonstrated that ammonia did indeed catalyze the cleavage of PLGA ester bonds during microencapsulation. Strikingly, PLGA degradation was affected by solvent type and volume, as well as ammonia concentration. For instance, when 6 ml of ethyl acetate was used and the molar ratio of ammonia to the solvent was 3, the glycolide content and M(w) of the microspheres considerably decreased to 17.56% and 10,814 g/mol, respectively. There were little changes in these terms, however, when microspheres were prepared using 3 ml of isopropyl formate and an equimolar amount of ammonia. Depending upon microencapsulation conditions, progesterone encapsulation efficiency ranged from 71.6 to 98.8%. Also, its release behavior was significantly influenced by ammonolysis-related process parameters. Our study demonstrated that all these contrasting results arose from differences in solvent reactivity toward ammonolysis, the rate of microsphere solidification, and the availability of ammonia to PLGA ester linkages.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Heo S,Lee M,Lee S,Sah H

doi

10.1016/j.ijpharm.2011.07.022

subject

Has Abstract

pub_date

2011-10-31 00:00:00

pages

60-70

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)00653-3

journal_volume

419

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • An in vitro kinetic method for detection of precipitation of poorly soluble drugs.

    abstract：:A simple in vitro method for the detection of precipitation using 96-well microplates and a SpectraMax Plus microtiter plate reader has been developed and described. The method requires only small amount of drug and is, therefore, potentially applicable in early pre-formulation. The method is based on opacity changes ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.08.012

    authors： Wu Z,Tucker IG,Razzak M,Medlicott NJ

    更新日期：2005-11-04 00:00:00

  • Data-smart machine learning methods for predicting composition-dependent Young's modulus of pharmaceutical compacts.

    abstract：:The ability to predict mechanical properties of compacted powder blends of Active Pharmaceutical Ingredients (API) and excipients solely from component properties can reduce the amount of 'trial-and-error' involved in formulation design. Machine Learning (ML) can reduce model development time and effort with the imper...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.120049

    authors： Thomas S,Palahnuk H,Amini H,Akseli I

    更新日期：2021-01-05 00:00:00

  • Influence of dry granulation on compactibility and capping tendency of macrolide antibiotic formulation.

    abstract：:The effect of dry granulation (roller compaction and slugging) on compactibility and tablet capping tendency in a formulation with macrolide antibiotic and microcrystalline cellulose (MCC) was investigated. Direct tableting of this formulation revealed a pronounced capping tendency. Both dry granulated systems exhibit...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.023

    authors： Bozic DZ,Dreu R,Vrecer F

    更新日期：2008-06-05 00:00:00

  • Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy.

    abstract：:The main objective of this study was to improve the safety and oxidative stability of glycerol monooleate (GMO)-based dry-emulsion (DE) formulation containing cyclosporine A (CsA) for inhalation therapy. GMO or highly purified GMO (hpGMO) was used as surfactant for the DE formulations (GMO/DE or hpGMO/DE), the toxicol...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.03.026

    authors： Sato H,Ogawa K,Kojo Y,Kawabata Y,Mizumoto T,Yamada S,Onoue S

    更新日期：2013-05-01 00:00:00

  • Silicon microfluidic flow focusing devices for the production of size-controlled PLGA based drug loaded microparticles.

    abstract：:The increasing realisation of the impact of size and surface properties on the bio-distribution of drug loaded colloidal particles has driven the application of micro fabrication technologies for the precise engineering of drug loaded microparticles. This paper demonstrates an alternative approach for producing size c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.03.051

    authors： Keohane K,Brennan D,Galvin P,Griffin BT

    更新日期：2014-06-05 00:00:00

  • Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting.

    abstract：:A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using 125I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.06.044

    authors： Farrag NS,El-Sabagh HA,Al-Mahallawi AM,Amin AM,AbdEl-Bary A,Mamdouh W

    更新日期：2017-08-30 00:00:00

  • Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model validation.

    abstract：:Although the extraordinary solubility advantage afforded by cyclodextrins has led to their widespread use as pharmaceutical solubilizers, several reports have emerged that cyclodextrins may also reduce the apparent permeability of the drug. With the purpose to investigate this solubility-permeability interplay, we hav...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.017

    authors： Miller JM,Dahan A

    更新日期：2012-07-01 00:00:00

  • A novel antibacterial agent based on AgNPs and Fe3O4 loaded chitin microspheres with peroxidase-like activity for synergistic antibacterial activity and wound-healing.

    abstract：:In this study, a novel antibacterial agent was developed based on chitin nanofibrous microspheres loaded with AgNPs and Fe3O4 nanoparticles (Ag-Fe3O4-NMs) for synergistic antibacterial activity and wound healing. Ag-Fe3O4-NMs was prepared via an in situ synthetic method which showed an excellent porosity and wettabili...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.10.002

    authors： Yu N,Cai T,Sun Y,Jiang C,Xiong H,Li Y,Peng H

    更新日期：2018-12-01 00:00:00

  • Characterization of strain rate sensitivity in pharmaceutical materials using indentation creep analysis.

    abstract：:Understanding how a material's response to stress changes as the stress is applied at different rates is important in predicting performance of pharmaceutical powders during tablet compression. Widely used methods for determining strain rate sensitivity (SRS) are empirically based and can often provide inconsistent or...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.09.006

    authors： Katz JM,Buckner IS

    更新日期：2013-02-14 00:00:00

  • Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers.

    abstract：:In this study, the potential of lecithin/chitosan nanoparticles (NPs) as a mucoadhesive colloidal nanosystem for transmucosal delivery of melatonin was investigated. The size, zeta potential and melatonin loading of the lecithin/chitosan NPs were investigated as a function of lecithin type (Lipoid S45, S75 and S100) a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.07.001

    authors： Hafner A,Lovrić J,Voinovich D,Filipović-Grcić J

    更新日期：2009-11-03 00:00:00

  • Therapeutic efficacy of sustained drug release from chitosan gel on local inflammation.

    abstract：:The model anti-inflammatory drug prednisolone (PS) was retained in chitosan (CS) gel beads, which were prepared in a 10% aqueous amino acid solution (pH 9.0). Sustained release of PS from the CS gel beads was observed. Carrageenan solution was injected into air pouches (AP), which were prepared subcutaneously on the d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.11.036

    authors： Kofuji K,Akamine H,Qian CJ,Watanabe K,Togan Y,Nishimura M,Sugiyama I,Murata Y,Kawashima S

    更新日期：2004-03-19 00:00:00

  • Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice.

    abstract：:The purpose of this study was to characterize the in vitro properties of a number of chitosan-based microemulsions containing nobiletin and determine its distribution in mice brain following i.v. administration. The phase behavior and properties of chitosan-based microemulsions were investigated in a pseudo-ternary sy...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.10.010

    authors： Yao J,Zhou JP,Ping QN,Lu Y,Chen L

    更新日期：2008-03-20 00:00:00

  • Gelatin-based membrane containing usnic acid-loaded liposome improves dermal burn healing in a porcine model.

    abstract：:There are a range of products available which claim to accelerate the healing of burns; these include topical agents, interactive dressings and biomembranes. The aim of this study was to assess the effect of a gelatin-based membrane containing usnic acid/liposomes on the healing of burns in comparison to silver sulfad...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.09.040

    authors： Nunes PS,Rabelo AS,Souza JC,Santana BV,da Silva TM,Serafini MR,Dos Passos Menezes P,Dos Santos Lima B,Cardoso JC,Alves JC,Frank LA,Guterres SS,Pohlmann AR,Pinheiro MS,de Albuquerque RL Júnior,Araújo AA

    更新日期：2016-11-20 00:00:00

  • rhEGF/HP-beta-CD complex in poloxamer gel for ophthalmic delivery.

    abstract：:The purpose of the present study is to prepare chemically and physically stable rhEGF/poloxamer gel and to investigate its possibility of ophthalmic delivery. The rhEGF/HP-beta-CD complex markedly increased rhEGF stability compared with rhEGF solution at 4 degrees C. The poloxamer gel was composed of poloxamer 407 (16...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00933-4

    authors： Kim EY,Gao ZG,Park JS,Li H,Han K

    更新日期：2002-02-21 00:00:00

  • Impact of capsule type on aerodynamic performance of inhalation products: A case study using a formoterol-lactose binary or ternary blend.

    abstract：:The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the micronized drug during the inhalation. This study evaluated the impact of gelat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.10.034

    authors： Wauthoz N,Hennia I,Ecenarro S,Amighi K

    更新日期：2018-12-20 00:00:00

  • Development of a PAT tool for monitoring the Wurster coater performance.

    abstract：:Real-time process analytical technology (PAT) is proposed as an effective approach for monitoring the performance of a Wurster coater. The coater was used for coating of 0.78 mm pharmaceutical pellets. The coating solution consisted of Hydroxypropyl methylcellulose/Poly ethylene glycol. During the coating process, sma...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.02.023

    authors： Foroughi-Dahr M,Sotudeh-Gharebagh R,Mostoufi N

    更新日期：2019-04-20 00:00:00

  • Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

    abstract：:9-(2-phosphonyomethoxypropyl)adenine (PMPA) and AMD3100 are highly potent and selective antiretroviral agents. Since PMPA is negatively charged and AMD3100 positively charged at physiological pH, their transepithelial transport and their potential for oral drug delivery is very low. In this study, ion pair formation w...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00150-7

    authors： Van Gelder J,Witvrouw M,Pannecouque C,Henson G,Bridger G,Naesens L,De Clercq E,Annaert P,Shafiee M,Van den Mooter G,Kinget R,Augustijns P

    更新日期：1999-09-20 00:00:00

  • Development of medicated foams that combine incompatible hydrophilic and lipophilic drugs for psoriasis treatment.

    abstract：:The focus was on the development of medicated foam for incorporation of two incompatible active agents for psoriasis treatment; i.e., lipophilic cholecalciferol, and hydrophilic salicylic acid. Emphasis was given to formulation of a propellant-free foam, with sufficient foaming properties, physical and chemical stabil...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.03.061

    authors： Mirtič J,Papathanasiou F,Temova Rakuša Ž,GosencaMatjaž M,Roškar R,Kristl J

    更新日期：2017-05-30 00:00:00

  • Lectin-mediated drug delivery: binding and uptake of BSA-WGA conjugates using the Caco-2 model.

    abstract：:To examine whether the dietary lectin wheat germ agglutinin (WGA) can facilitate binding and uptake of protein drugs due to its cytoadhesive and cytoinvasive properties, conjugates were prepared by covalent coupling of fluorescein-labeled bovine serum albumin (F-BSA) to WGA using divinylsulfone for crosslinking. Incre...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00049-2

    authors： Gabor F,Schwarzbauer A,Wirth M

    更新日期：2002-04-26 00:00:00

  • Enabling real time release testing by NIR prediction of dissolution of tablets made by continuous direct compression (CDC).

    abstract：:A method for predicting dissolution profiles of directly compressed tablets for a fixed sustained release formulation manufactured in a continuous direct compaction (CDC) system is presented. The methodology enables real-time release testing (RTRt). Tablets were made at a target drug concentration of 9% Acetaminophen,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.033

    authors： Pawar P,Wang Y,Keyvan G,Callegari G,Cuitino A,Muzzio F

    更新日期：2016-10-15 00:00:00

  • Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.

    abstract：:To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.11.001

    authors： Uchimoto T,Iwao Y,Ikegami Y,Murata T,Sonobe T,Miyagishima A,Itai S

    更新日期：2010-02-15 00:00:00

  • Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.

    abstract：:Proquazone, a poorly wettable compound, was used as a model drug in the search for reasons to develop a capsule or tablet formulation. The capsules were filled with proquazone as active ingredient, with lactose monohydrate (200 mesh) as filler and with magnesium stearate as lubricant. The tablet was made out of a gran...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.09.006

    authors： von Orelli J,Leuenberger H

    更新日期：2004-12-09 00:00:00

  • The use of MTDSC to assess the amorphous phase content of a micronized drug substance.

    abstract：:Mechanical treatments such as grinding, milling or micronization applied to crystalline drug substances may induce changes such as the occurrence of crystal defects and/or amorphous regions. These changes are likely to affect the chemical and physical properties of the material as well as the corresponding drug produc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00273-2

    authors： Guinot S,Leveiller F

    更新日期：1999-12-01 00:00:00

  • Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.

    abstract：:The purpose of this study was to engineer nanoparticles with various sustained profiles of drug release and prolonged circulation by blending poly(D,L-lactic acid)/poly(D,L-lactic/glycolic acid) (PLA/PLGA) homopolymers and poly(ethylene glycol) (PEG)-block-PLA/PLGA copolymers encapsulating betamethasone disodium 21-ph...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.001

    authors： Ishihara T,Kubota T,Choi T,Takahashi M,Ayano E,Kanazawa H,Higaki M

    更新日期：2009-06-22 00:00:00

  • Influence of formulation on jet nebulisation quality of alpha 1 protease inhibitor.

    abstract：:As foam appears during solution constitution and nebulisation of alpha 1 protease inhibitor (alpha 1 PI), we selected in a previous work, antifoams likely to be associated with an alpha 1 PI solution to be nebulised: span 65 at a 0.025% concentration and cetyl alcohol at a 0.05% concentration associated with tyloxapol...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(98)00354-8

    authors： Flament MP,Leterme P,Burnouf T,Gayot A

    更新日期：1999-02-01 00:00:00

  • Anion effects on electrostatic charging of sterically stabilized, water insoluble drug particles.

    abstract：:Water-insoluble suspensions of itraconazole and budesonide were sterically stabilized using nonionic polymers (poloxamer 188 or polysorbate 80) and probed for polymer-anion interactions by measuring changes in particle zeta potential. Anions comprising a range of functionalities and aqueous solubilities were examined....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.10.004

    authors： Owen H,Graham S,Werling JO,Carter PW

    更新日期：2009-02-23 00:00:00

  • Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine.

    abstract：:Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.05.009

    authors： Radmanesh F,Abandansari HS,Pahlavan S,Alikhani M,Karimi M,Rajabi S,Kazemi B,Baharvand H

    更新日期：2019-06-30 00:00:00

  • Insulin containing polyethylenimine-dextran sulfate nanoparticles.

    abstract：:An aqueous nanoparticle delivery system has been developed which employs the oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS) with zinc as a stabilizer. It is found that the pH of PEI solutions, the weight ratio of the two polymers, and zinc sulfate concentrations all play significant roles ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00055-3

    authors： Tiyaboonchai W,Woiszwillo J,Sims RC,Middaugh CR

    更新日期：2003-04-14 00:00:00

  • Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation.

    abstract：:Granules with release-sustaining properties were developed by twin screw hot melt granulation (HMG) using a combination of stearic acid (SA) and high molecular weight polyethylene oxide (PEO) as matrix for a highly water soluble model drug, metoprolol tartrate (MPT). Earlier studies demonstrated that mixing molten SA ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.035

    authors： Monteyne T,Adriaensens P,Brouckaert D,Remon JP,Vervaet C,De Beer T

    更新日期：2016-10-15 00:00:00

  • Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres.

    abstract：:The incomplete release of Endostar from PLGA microspheres was observed in our previous study. In the present study, we focused on the effect of medium-chain triglycerides (MCT) on the in vitro/in vivo release behavior of Endostar encapsulated PLGA microspheres, which were prepared by a water-in-oil-in-water (W/O/W) do...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.07.018

    authors： Meng B,Li L,Hua S,Wang Q,Liu C,Xu X,Yin X

    更新日期：2010-09-15 00:00:00