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Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting.

Abstract：

:A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using 125I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time. The reported highly efficient method provides new radiolabeled Ag-based NPs as tumor-specific agents for both diagnostic and therapeutic applications.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Farrag NS,El-Sabagh HA,Al-Mahallawi AM,Amin AM,AbdEl-Bary A,Mamdouh W

doi

10.1016/j.ijpharm.2017.06.044

subject

Has Abstract

pub_date

2017-08-30 00:00:00

pages

123-133

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(17)30552-5

journal_volume

529

pub_type

杂志文章

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