Abstract：
:Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by (1)H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG-PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Zheng X,Kan B,Gou M,Fu S,Zhang J,Men K,Chen L,Luo F,Zhao Y,Zhao X,Wei Y,Qian Zdoi
10.1016/j.ijpharm.2009.11.014subject
Has Abstractpub_date
2010-02-15 00:00:00pages
262-7issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(09)00816-3journal_volume
386pub_type
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