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Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin.

Abstract：

:Amino poly(glycerol methacrylate)s (PGOHMAs) were synthesized from linear or star-shaped poly(glycidyl methacrylate)s (PGMA)s via ring opening reactions with 1,2-ethanediamine, 1,4-butanediamine and diethylenetriamine, respectively. The resulting cationic polymers were employed to form polyelectrolyte complexes (PECs) with insulin. Parameters influencing complex formation were investigated by dynamic light scattering (DLS). PECs in the size range of 100-200 nm were obtained under optimal conditions, i.e., the pH value of PECs was 5.58-6.27, the concentration of NaCl was 0.02 mol/L, and insulin-polymer weight ratio was 0.8. The insulin association efficiency (AE) of current system increased with zeta potentials of PECs. Circular dichroism (CD) analysis corroborated that the structure of insulin in the PEC nanoparticles was preserved after lyophilization. Fourier transform infrared (FT-IR) and X-ray diffraction (XRD) experiments demonstrated that weak physical interactions between insulin and amino PGOHMAs play an important role in the formation of PECs. The release of insulin depends on both structure and architecture of amino PGOHMAs. These PECs would be potentially useful for mucosal administration.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Lu X,Gao H,Li C,Yang YW,Wang Y,Fan Y,Wu G,Ma J

doi

10.1016/j.ijpharm.2011.12.017

subject

Has Abstract

pub_date

2012-02-28 00:00:00

pages

195-201

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)01143-4

journal_volume

423

pub_type

杂志文章

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