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A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles.

Abstract：

:Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency. Chitosan (Chi) was included to prepare chitosan coated SLN's. Particle size analysis revealed a sub-micron size range (300.3±31.75 nm to 495.1±80.42 nm), with chitosan containing particles having the largest dimensions. As expected, chitosan (0.1%, 0.2% and 0.4% w/v) conferred a net positive charge on the particle surface in a concentration dependent manner. For iron absorption experiments equal doses of Fe (20 μM) from selected formulations (SLN-FeA and SLN-Fe-ChiB) were added to Caco-2 cells and intracellular ferritin protein concentrations determined. Caco-2 iron absorption from SLN-FeA (583.98±40.83 ng/mg cell protein) and chitosan containing SLN-Fe-ChiB (642.77±29.37 ng/mg cell protein) were 13.42% and 24.9% greater than that from ferrous sulphate (FeSO4) reference (514.66±20.43 ng/mg cell protein) (p≤0.05). We demonstrate for the first time preparation, characterisation and superior iron absorption in vitro from SLN's, suggesting the potential of these formulations as a novel system for oral iron delivery.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Zariwala MG,Elsaid N,Jackson TL,Corral López F,Farnaud S,Somavarapu S,Renshaw D

doi

10.1016/j.ijpharm.2013.08.070

subject

Has Abstract

pub_date

2013-11-18 00:00:00

pages

400-7

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(13)00803-X

journal_volume

456

pub_type

杂志文章

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