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Determination of bisphenol A in water and the medical devices used in hemodialysis treatment.

Abstract：

:Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of overall potential exposure to BPA during hemodialysis treatment in patients suffering from end-stage renal disease. BPA concentration in water (at each step of purification treatment) and in dialysate and BPA leaching from dialyzers were determined using solid-phase extraction coupled to ultra-high-performance-liquid chromatography tandem mass spectrometry. We have corroborated the hypothesis that a significant amount of BPA may migrate from dialyzers and also demonstrated that BPA is provided by the water used in dialysate production (8.0±5.2ngL(-1) on average) and by dialysis machine and dialysate cartridges, leading to dialysate contamination of 22.7±15.6ngL(-1) on average. Taking into account all the sources of BPA contamination that may come into play during a hemodialysis session, the highest exposure could reach an estimated 140ng/kg b.w./day for hemodialyzed patients, directly available for systemic exposure. Finally, BPA contamination should be taken into account as concerns both the medical devices commonly used in hemodialysis and purified water production systems.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

doi

10.1016/j.ijpharm.2016.03.003

subject

Has Abstract

pub_date

2016-05-30 00:00:00

pages

115-21

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(16)30193-4

journal_volume

505

pub_type

杂志文章

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