Abstract：
:The use of non-linear mixed effects models to describe dissolution data has been evaluated. A theoretical part is included to introduce this approach to scientists who are not familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several mathematical functions like the Weibull, logistic, first-order and Gompertz are employed as basis for the non-linear mixed effects models. Examples are given using dissolution data of immediate and extended release tablets. The results are compared with those obtained using linear mixed effects models.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Adams E,Coomans D,Smeyers-Verbeke J,Massart DLdoi
10.1016/s0378-5173(02)00127-8keywords:
subject
Has Abstractpub_date
2002-06-20 00:00:00pages
37-53issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517302001278journal_volume
240pub_type
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