当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process.

Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process.

Abstract：

:The objectives of this study were to develop an electrostatic dry powder coating process for sustained coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the coating process and drug release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted coating deposition was confirmed by the fact that higher coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug release profiles indicated that curing time, temperature, coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained release profile. The electrostatic dry powder coating process has been demonstrated to be an alternative for tablet sustained release coating with Eudragit(®) RS and RL.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Qiao M,Luo Y,Zhang L,Ma Y,Stephenson TS,Zhu J

doi

10.1016/j.ijpharm.2010.07.047

subject

Has Abstract

pub_date

2010-10-31 00:00:00

pages

37-43

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(10)00574-0

journal_volume

399

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Incorporation of a model protein into chitosan-bile salt microparticles.

    abstract：:In order to develop a mucosal delivery system based on biocompatible polymers, a new methodology for production of protein-loaded microparticles is developed. Chitosan anionic precipitation/coacervation is accomplished by the addition of sodium deoxycholate (DCA). These microparticles were prepared under mild conditio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.01.006

    authors： Lameiro MH,Lopes A,Martins LO,Alves PM,Melo E

    更新日期：2006-04-07 00:00:00

  • Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution.

    abstract：:Superdisintegrants are a key excipient used in immediate release formulations to promote fast tablet disintegration, therefore understanding the impact of superdisintegrant variability on product performance is important. The current study examined the impact of superdisintegrant critical material attributes (viscosit...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119080

    authors： Zarmpi P,Flanagan T,Meehan E,Mann J,Fotaki N

    更新日期：2020-03-15 00:00:00

  • A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.

    abstract：:We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.12.038

    authors： Sato T,Mizuno K,Ishii F

    更新日期：2009-05-08 00:00:00

  • Biocompatible, biodegradable and sterically stabilized phospholipid nanomicelles improve cryopreservation of oral keratinocytes: a preliminary investigation.

    abstract：:In this proof-of principle study, we determined whether biocompatible, biodegradable and sterically stabilized phospholipid nanomicelles (SSNMs) improve viability and membrane integrity of cryopreserved oral keratinocytes. Cultured chemically transformed hamster oral keratinocytes were frozen gradually with and stored...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.02.002

    authors： Rubinstein I,Onyüksel H

    更新日期：2007-06-29 00:00:00

  • Formulation of self-microemulsifying drug delivery system (SMEDDS) by D-optimal mixture design to enhance the oral bioavailability of a new cathepsin K inhibitor (HL235).

    abstract：:HL235 is a new cathepsin K inhibitor designed and synthesized to treat osteoporosis. Since HL235 has poor aqueous solubility, a self-microemulsifying drug delivery system (SMEDDS) was formulated to enhance its oral bioavailability. A solubility study of HL235 was performed to select a suitable oil, surfactant and cosu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118772

    authors： Visetvichaporn V,Kim KH,Jung K,Cho YS,Kim DD

    更新日期：2020-01-05 00:00:00

  • Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs.

    abstract：:Nanostructured lipid-based liquid crystalline systems have been proposed as sustained oral drug delivery systems, but the interplay between their intrinsic release rates, susceptibility to digestive processes, and the manner in which these effects impact on their application in vivo, are not well understood. In this s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.022

    authors： Lee KW,Nguyen TH,Hanley T,Boyd BJ

    更新日期：2009-01-05 00:00:00

  • Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders.

    abstract：:Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248n...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.015

    authors： Visan A,Stan GE,Ristoscu C,Popescu-Pelin G,Sopronyi M,Besleaga C,Luculescu C,Chifiriuc MC,Hussien MD,Marsan O,Kergourlay E,Grossin D,Brouillet F,Mihailescu IN

    更新日期：2016-09-10 00:00:00

  • Swelling, melting point reduction and solubility of PEG 1500 in supercritical CO2.

    abstract：:The knowledge of the solubility of PEG 1500 as well as the swelling and melting point variation in supercritical CO(2) in a relatively high-pressure range is a necessary prerequisite to set-up pharmaceutical processes dealing with the polymer in the molten state. Experiments carried out in a pressurized view cell indi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.048

    authors： Pasquali I,Comi L,Pucciarelli F,Bettini R

    更新日期：2008-05-22 00:00:00

  • Influence of methyl-beta-cyclodextrin and liposomes on rheological properties of Carbopol 974P NF gels.

    abstract：:The influence of positively-charged and sterically stabilized liposomes and/or methyl-beta-cyclodextrin on rheological properties of Carbopol 974P NF hydrogels was investigated. All formulations have displayed a shear-thinning behavior of Carbopol gels, and the rate stress as a function of the shear rate was fitted us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00683-x

    authors： Boulmedarat L,Grossiord JL,Fattal E,Bochot A

    更新日期：2003-03-18 00:00:00

  • Development of low dose micro-tablets by high shear wet granulation process.

    abstract：:Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges associated with directly compressed low dose micro-tablets, in this study...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119571

    authors： Gupta S,Thool P,Meruva S,Li J,Patel J,Agrawal A,Karki S,Bowen W,Mitra B

    更新日期：2020-09-25 00:00:00

  • Secondary structure alterations in insulin and growth hormone water-in-oil emulsions.

    abstract：:Water-in-oil (w/o) emulsions have shown a promising release profile of small drug molecules and proteins. However, the major concerns are the structural stability, the retention of the activity and to avoid unwanted immunological reactions caused by the changes in protein structure. In the present study, the secondary...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00668-3

    authors： Jørgensen L,Vermehren C,Bjerregaard S,Froekjaer S

    更新日期：2003-03-18 00:00:00

  • Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats.

    abstract：:The purpose of this work was to investigate distribution, transition, bioadhesion and release behaviors of insulin loaded pH-sensitive nanoparticles in the gut of rats, as well as the effects of viscosity agent on them. Insulin was labeled with fluorescein isothiocyanate (FITC). The FITC-insulin solution and FITC-insu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.040

    authors： Li MG,Lu WL,Wang JC,Zhang X,Wang XQ,Zheng AP,Zhang Q

    更新日期：2007-02-01 00:00:00

  • Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.

    abstract：:Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid the acidic conversion of lovastatin to its hydroxyacid derivative. In a two-step process, sucrose beads were layered with a glass solution of ezetimibe, lovastatin and Soluplus®, top-coated with an ent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.01.053

    authors： Riekes MK,Dereymaker A,Berben P,Augustijns P,Stulzer HK,Van den Mooter G

    更新日期：2017-03-30 00:00:00

  • Effect of different ratios of high and low molecular weight PLGA blend on the characteristics of pentamidine microcapsules.

    abstract：:Two different PLGA samples (Resomer 502 and Resomer 506), either alone or in combinations, were used to prepare microcapsules. Microcapsules were prepared using a double emulsion solvent evaporation technique. The efficiency of encapsulation increased significantly when a mixture of 1 part Resomer 506 and 7 parts Reso...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.10.019

    authors： Graves RA,Pamujula S,Moiseyev R,Freeman T,Bostanian LA,Mandal TK

    更新日期：2004-02-11 00:00:00

  • Influence of dissolution medium buffer composition on ketoprofen release from ER products and in vitro-in vivo correlation.

    abstract：:The purpose of this work was to investigate the influence of dissolution medium composition on the in vitro release of ketoprofen from a series of ER products and the impact of the different buffer media on the in vivo-in vitro (IVIV) relationship. The products investigated were coated micro bead preparations having i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00004-8

    authors： Corrigan OI,Devlin Y,Butler J

    更新日期：2003-03-26 00:00:00

  • The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether.

    abstract：:Niosomes are vesicles formed by self-assembly of non-ionic surfactants. In this investigation, the effects of processing variables, particularly temperature and sonication, on the physical characteristics and phase transitional behaviour of two niosomal systems based on a hexadecyl diglycerol ether (C(16)G(2)) have be...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00362-8

    authors： Arunothayanun P,Bernard MS,Craig DQ,Uchegbu IF,Florence AT

    更新日期：2000-05-15 00:00:00

  • Development of controlled-release cisplatin dry powders for inhalation against lung cancers.

    abstract：:The present study focuses on the development of dry powders for inhalation as adjuvant chemotherapy in lung cancer treatment. Cisplatin was chosen as a potential candidate for a local treatment as it remains the main platinum component used in conventional chemotherapies, despite its high and cumulative systemic toxic...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.019

    authors： Levet V,Rosière R,Merlos R,Fusaro L,Berger G,Amighi K,Wauthoz N

    更新日期：2016-12-30 00:00:00

  • Evaluation of novel formulations of d-β-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock.

    abstract：:d-β-hydroxybutyrate and melatonin (BHB/MLT) infusion improves survival in hemorrhagic shock models. The original BHB/MLT formulation contains dimethyl sulfoxide (DMSO) to increase melatonin solubility. We formulated BHB/MLT solutions wherein DMSO was replaced either with 10% polyvinylpyrrolidone (BHB/MLT/PVP) or with ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.046

    authors： Wolf A,Thakral S,Mulier KE,Suryanarayanan R,Beilman GJ

    更新日期：2018-09-05 00:00:00

  • Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model.

    abstract：:Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mai...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119318

    authors： Rotrekl D,Devriendt B,Cox E,Kavanová L,Faldyna M,Šalamúnová P,Baďo Z,Prokopec V,Štěpánek F,Hanuš J,Hošek J

    更新日期：2020-05-30 00:00:00

  • Inertial sizing of aerosol inhaled from two dry powder inhalers with realistic breath patterns versus constant flow rates.

    abstract：:A procedure is developed that allows particles inhaled with realistic breath patterns to be sized by cascade impaction at a constant flow rate. This procedure is then used to examine the difference between particle sizes obtained with constant flow rate (step profile) versus actual-subject breath patterns for two dry ...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0378-5173(00)00569-x

    authors： Finlay WH,Gehmlich MG

    更新日期：2000-12-04 00:00:00

  • Cosolvency approach for assessing the solubility of drugs in poly(vinylpyrrolidone).

    abstract：:The log-linear cosolvency model was applied for estimating the solubility of four drugs: ritonavir, griseofulvin, itraconazole and ketoconazole in poly(vinylpyrrolidone) (PVP). Cosolvent mixtures consisted of PVP mixed in different proportions with N-ethylpyrrolidone, which served as the monomeric analogue of the repe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.016

    authors： Chen X,Fadda HM,Aburub A,Mishra D,Pinal R

    更新日期：2015-10-15 00:00:00

  • TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

    abstract：:TXA497 is representative of a new class of guanidinomethyl biaryl compounds that exhibit potent bactericidal behavior against methicillin-resistant Staphylococcus aureus (MRSA). In this study, we compared the anti-staphylococcal, skin deposition, and skin permeation properties of TXA497 and the topical anti-MRSA antib...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.09.033

    authors： Dorrani M,Kaul M,Parhi A,LaVoie EJ,Pilch DS,Michniak-Kohn B

    更新日期：2014-12-10 00:00:00

  • Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.

    abstract：:Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.04.019

    authors： Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

    更新日期：2005-08-26 00:00:00

  • Strain-specific differences in behaviour among Lacticaseibacillus rhamnosus cell wall mutants during direct compression.

    abstract：:The human body harbours a large variety of microbial communities. It is already well-known that these communities play an important role in human health. Therefore, microbial imbalances can be responsible for several health disorders by different mechanisms. In recent years, probiotic bacteria have been increasingly a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119755

    authors： Byl E,Jokicevic K,Kiekens S,Lebeer S,Kiekens F

    更新日期：2020-10-15 00:00:00

  • Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods.

    abstract：:We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(98)00381-0

    authors： Gamisans F,Lacoulonche F,Chauvet A,Espina M,García ML,Egea MA

    更新日期：1999-03-01 00:00:00

  • Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy.

    abstract：:The objective of this study was the development of a niosomal formulation for improving skin permeation and penetration of 5-aminolevulinic acid (ALA) in the treatment of skin malignancies by photodynamic therapy (PDT). Different niosomal dispersions were prepared, using two different preparation methods. The effect o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.036

    authors： Bragagni M,Scozzafava A,Mastrolorenzo A,Supuran CT,Mura P

    更新日期：2015-10-15 00:00:00

  • The synergistic fungicidal effect of low-frequency and low-intensity ultrasound with amphotericin B-loaded nanoparticles on C. albicans in vitro.

    abstract：:It is difficult to effectively eradicate C. albicans using traditional antifungal agents, mainly because the low permeability of the C. albicans cell wall creates strong drug resistance. The aim of this study was to investigate the synergistic fungicidal effect and the underlying mechanisms of low-frequency and low-in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.033

    authors： Yang M,Xie S,Adhikari VP,Dong Y,Du Y,Li D

    更新日期：2018-05-05 00:00:00

  • Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms.

    abstract：:In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion spheronization and ER characteristics were obtained after fluid bed ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.049

    authors： Schrank S,Jedinger N,Wu S,Piller M,Roblegg E

    更新日期：2016-07-25 00:00:00

  • Prolonged subcutaneous delivery of low molecular weight heparin based on thermoresponsive hydrogels with chitosan nanocomplexes: Design, in vitro evaluation, and cytotoxicity studies.

    abstract：:Low molecular weight heparins (LMWHs) have risen in popularity over the past decades. Owing to their appropriate pharmacokinetic profile, they enable long-term clinical applications, e.g. prophylaxis of deep vein thrombosis. Although the administration of LMWHs is not as frequent as of heparin, it still requires once ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.04.063

    authors： Radivojša Matanović M,Grabnar I,Gosenca M,Grabnar PA

    更新日期：2015-07-05 00:00:00

  • A high throughput platform for understanding the influence of excipients on physical and chemical stability.

    abstract：:The present study puts forward a miniaturized high-throughput platform to understand influence of excipient selection and processing on the stability of a given drug compound. Four model drugs (sodium naproxen, theophylline, amlodipine besylate and nitrofurantoin) and ten different excipients were selected. Binary phy...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.08.025

    authors： Raijada D,Cornett C,Rantanen J

    更新日期：2013-08-30 00:00:00