The effect of ultraviolet radiation on the anti-inflammatory effect of filters.

Abstract:

:A certain number of filters have notable anti-inflammatory properties with percentage inhibition of PMA-induced edema in mice at over 70%. The question arose as to whether this effect was likely to continue after UV irradiation. It can be noted that 7 filters retain an equivalent anti-inflammatory effect before and after 2h of irradiation in a Suntest device (650 W/m(2)). For 9 filters, the anti-inflammatory effect decreases and for 5 filters, the anti-inflammatory effect increases. Various behaviors should be noted. 3 groups of substances can be distinguished: such as phenylbenzimidazole sulfonic acid which loses its anti-inflammatory character after irradiation (the percentage inhibition falls from 80 to 44%), oxybenzone which retains a constant anti-inflammatory character (89% inhibition before and after irradiation and also octyl methoxycinnamate which becomes very anti-inflammatory (with a percentage inhibition of 93%). The same phenomenon is observed in the case of commercial products. This should be made known as it can have a considerable impact on the results which are displayed on the packaging of sun products.

journal_name

Int J Pharm

authors

Couteau C,Couteau O,Chauvet C,Paparis E,Coiffard LJ

doi

10.1016/j.ijpharm.2013.04.067

subject

Has Abstract

pub_date

2013-08-16 00:00:00

pages

124-7

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(13)00368-2

journal_volume

452

pub_type

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