Abstract：
:Ciprofloxacin (CPX) physicochemical properties, mainly hydrophobicity and microspeciation, appear to be related with the ability of this drug to adsorb and diffuse through lipid environments. We have combined the information from fluorescence anisotropy, quenching and epifluorescence of phospholipid monolayers, to explore effects of CPX at the phospholipid-buffer interface. Two fluorescent probes (TMA-DPH and PA-DPH) located at surface level were used for anisotropy experiments. The results evidenced that CPX interact with liposomes at surface level and induce a moderate decrease in the bilayer anisotropy. By using two hydrophobic quenchers (iodobenzene and iododecanoic acid) the presence of CPX in the core of the bilayer was excluded. Mixed monolayers of DPPC and CPX evidenced the ability of CPX to compress the monolayer and the epifluorescence observations showed that CPX modifies lipid distribution and surface phase transition. The surface activity of CPX is reviewed from the physicochemical properties of the drug and in relation to its pharmacological activity.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Hernández-Borrell J,Montero MTdoi
10.1016/s0378-5173(02)00633-6keywords:
subject
Has Abstractpub_date
2003-02-18 00:00:00pages
149-57issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517302006336journal_volume
252pub_type
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