Abstract：
:The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of surgical repair such as autografts, allografts, and xenografts are confounded by donor site morbidity, immunogenicity, and disease transmission, respectively. In contrast, these risks may be alleviated via growth factor therapy, which can actively influence the healing environment to promote functional repair. Several challenges have to be overcome before growth factor delivery can translate into clinical practice such as the selection of optimal growth factor(s) or combination, identification of the most efficient stage and duration of delivery, and the design considerations for the delivery device. Emerging insight into the injury-repair microenvironment and our understanding of growth factor mechanisms in healing are informing the design of advanced delivery scaffolds to effectively treat rotator cuff tears. Here, we review potential growth factor candidates, design parameters and material selection for growth factor delivery, innovative and dynamic delivery scaffolds, and novel therapeutic targets from tendon and developmental biology for the structural and functional healing of rotator cuff repair.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Prabhath A,Vernekar VN,Sanchez E,Laurencin CTdoi
10.1016/j.ijpharm.2018.01.006subject
Has Abstractpub_date
2018-06-15 00:00:00pages
358-371issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(18)30006-1journal_volume
544pub_type
杂志文章,评审abstract：:For use in chronic oral chemotherapeutic regimens, the potent anticancer drug docetaxel needs a solid oral dosage form. Because docetaxel has a very low permeability and a very low aqueous solubility (biopharmaceutical classification system class IV), a pharmacokinetic booster was combined with a newly developed solid...
journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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