Abstract：
:A range of 17 ternary formulations of itraconazole (ITZ), HPMCP and Soluplus have been manufactured using spray drying. These amorphous solid dispersions (ASDs) were very stable against crystallisation and ITZ was found to be amorphous in all formulations after one year at 40°C/75% RH. A number of solid state analytical techniques including PXRD, DSC, small angle X-ray scattering, FTIR and solid state NMR were used to characterise the physicochemical properties of the ASDs following processing and storage and to assess any interactions between components. Microtrac laser scattering analysis revealed a relationship between polymer levels and particle size distribution (PSD). Dissolution studies indicated that higher Soluplus content in the formulation resulted in higher concentrations of ITZ in acidic media.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Davis MT,Potter CB,Mohammadpour M,Albadarin AB,Walker GMdoi
10.1016/j.ijpharm.2017.01.043subject
Has Abstractpub_date
2017-03-15 00:00:00pages
365-372issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30052-2journal_volume
519pub_type
杂志文章abstract：:The encapsulation of lipophilic drugs in polymeric nanoparticles can form simultaneously both polymeric nanoparticles and drug nanocrystals. The objective was to detect the presence of nanocrystals in the nanoparticle suspensions using a simple methodology, and to determine if the nanocrystals are formed during prepar...
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