当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Modelling nifedipine photodegradation, photostability and actinometric properties.

Modelling nifedipine photodegradation, photostability and actinometric properties.

Abstract：

BACKGROUND:The photodegradation of drugs obeying unimolecular mechanisms such as that of nifedipine (NIF) were usually characterised in the literature by zero-, first- and second-order kinetics. This approach has been met with varying success. This paper addresses this issue and proposes a novel approach for unimolecular photodegradation kinetics. The photodegradation of the cardiovascular drug nifedipine is investigated within this framework. METHODS:Experimental kinetic data of nifedipine photodegradation were obtained by continuous monochromatic irradiation and DAD analysis. Fourth-order Runge-Kutta calculated kinetic data served for the validation of the new semi-empirical integrated rate-law model proposed in this study. RESULTS:A new model equation has been developed and proposed which faithfully describes the kinetic behaviour of NIF in solution for non-isosbestic irradiations at wavelengths where both NIF and its photoproduct absorb. NIF absolute quantum yield values were determined and found to increase with irradiation wavelength according to a defined sigmoid relationship. The effects of increasing NIF or excipients' concentrations on NIF kinetics were successfully modelled and found to improve NIF photostability. The potential of NIF for actinometry has been explored and evaluated. A new reaction order (the so-called Φ-order) has been identified and specifically proposed for unimolecular photodegradation reactions. CONCLUSION:The semi-empirical and integrated rate-law models facilitated reliable kinetic studies of NIF photodegradation as an example of AB(1Φ) unimolecular reactions. It allowed filling a gap in kinetic studies of drugs since, thus far, thermal first-order or a combination of first- and zero- order kinetic equations were generally applied for drug photoreactions in the literature. Also, a new reaction order, the "Φ-order", has been evidenced and proposed as a specific alternative for photodegradation kinetics.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Maafi W,Maafi M

doi

10.1016/j.ijpharm.2013.07.075

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

153-64

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(13)00712-6

journal_volume

456

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Optimization of miRNA delivery by using a polymeric conjugate based on deoxycholic acid-modified polyethylenimine.

    abstract：:Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.05.009

    authors： Radmanesh F,Abandansari HS,Pahlavan S,Alikhani M,Karimi M,Rajabi S,Kazemi B,Baharvand H

    更新日期：2019-06-30 00:00:00

  • The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus.

    abstract：:The aim of this study was to examine the diffusion of commonly administered analgesics, ibuprofen and paracetamol, through gastric mucus. As ibuprofen and paracetamol are often formulated with alkalising excipients, or are commonly co-administered with antacids that have been demonstrated to alter their absorption, di...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.028

    authors： Shaw LR,Irwin WJ,Grattan TJ,Conway BR

    更新日期：2005-02-16 00:00:00

  • Preparation and characterization of mucoadhesive polymer-coated nanoparticles.

    abstract：:The transmucosal routes such as pulmonary, nasal and oral routes are most important and common routes for drug delivering to the body. However, peptide and protein drugs are degraded before they reach the blood stream and cannot cross the mucosal barriers. The mucoadhesive polymer-coated nanoparticles colloidal carrie...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.031

    authors： Cui F,Qian F,Yin C

    更新日期：2006-06-19 00:00:00

  • Characterization and biological properties of NanoCUR formulation and its effect on major human cytochrome P450 enzymes.

    abstract：:Curcumin (CUR) has been formulated into a host of nano-sized formulations in a bid to improve its in vivo solubility, stability and bioavailability. The aim of this study was to investigate whether the encapsulation of CUR in nanocarriers would impede its biological interactivity, specifically its potential anti-cance...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.066

    authors： Shamsi S,Chen Y,Lim LY

    更新日期：2015-11-10 00:00:00

  • The impact of channel fill level on internal forces during continuous twin screw wet granulation.

    abstract：:The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use of dye containing calibrated microencapsulated sensors (CAMES) whose rupture is directly depend...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.12.052

    authors： Mendez Torrecillas C,Gorringe LJ,Rajoub N,Robertson J,Elkes RG,Lamprou DA,Halbert GW

    更新日期：2019-03-10 00:00:00

  • Robustness testing, using experimental design, of a flow-through dissolution method for a product where the actives have markedly differing solubility properties.

    abstract：:The use of experimental design for the robustness testing of a flow-through dissolution method (Ph Eur/USP Apparatus 4) for atovaquone, one of the drug substances in a dual-active anti-malarial tablet formulation, Malarone tablets, is described. This procedure was developed to overcome the suppression of the atovaquon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00509-3

    authors： Bloomfield MS,Butler WC

    更新日期：2000-09-25 00:00:00

  • Effect of storage on microstructural changes of Carbopol polymers tracked by the combination of positron annihilation lifetime spectroscopy and FT-IR spectroscopy.

    abstract：:Different types of Carbopols are frequently applied excipients of various dosage forms. Depending on the supramolecular structure, their water sorption behaviour could significantly differ. The purpose of the present study was to track the supramolecular changes of two types of Carbopol polymers (Carbopol 71G and Ultr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.06.028

    authors： Szabó B,Süvegh K,Zelkó R

    更新日期：2011-09-15 00:00:00

  • Intravaginal rings for continuous low-dose administration of cervical ripening agents.

    abstract：:Intravaginal rings (VRs) have been widely reported for administration of pharmaceutical drugs - most notably estrogens, progestogens and antiretrovirals - to the vagina for clinical benefit. Here, for the first time, we describe the design, manufacture and preclinical testing of VRs for sustained/controlled release of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.053

    authors： Wang Y,Boyd P,Hunter A,Malcolm RK

    更新日期：2018-10-05 00:00:00

  • Application of spherical silicate to prepare solid dispersion dosage forms with aqueous polymers.

    abstract：:The objective of this study is to prepare and characterize solid dispersions of nifedipine (NP) using porous spherical silicate micro beads (MB) that were approximately 100 μm in diameter with vinylpyrrolidone/vinyl acetate copolymer (PVP/VA) and a Wurster-type fluidized bed granulator. Compared with previously report...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.037

    authors： Nagane K,Kimura S,Ukai K,Takahashi C,Ogawa N,Yamamoto H

    更新日期：2015-09-30 00:00:00

  • Developability assessment of clinical drug products with maximum absorbable doses.

    abstract：:Maximum absorbable dose refers to the maximum amount of an orally administered drug that can be absorbed in the gastrointestinal tract. Maximum absorbable dose, or D(abs), has proved to be an important parameter for quantifying the absorption potential of drug candidates. The purpose of this work is to validate the us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.02.003

    authors： Ding X,Rose JP,Van Gelder J

    更新日期：2012-05-10 00:00:00

  • Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus(®)-Solutol(®) HS15 binary mixed micelles system.

    abstract：:The aim of this study was to develop a novel drug delivery system using two biocompatible copolymers of Solutol(®)HS15 and Soluplus(®) to improve solubility, oral bioavailability and anticancer activity of paclitaxel (PTX). The PTX-loaded mixed micelles (PTX-M) were prepared by ethanol thin-film hydration method. The ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.045

    authors： Hou J,Sun E,Sun C,Wang J,Yang L,Jia XB,Zhang ZH

    更新日期：2016-10-15 00:00:00

  • The influence of high shear mixing on ternary dry powder inhaler formulations.

    abstract：:The blending process is a key step in the production of dry powder inhaler formulations, but only little is known about the influence of process parameters. This is especially true for high shear blending of ternary formulations. For this reason, this study aims to investigate the influence of high shear mixing proces...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.10.033

    authors： Hertel M,Schwarz E,Kobler M,Hauptstein S,Steckel H,Scherließ R

    更新日期：2017-12-20 00:00:00

  • Dynamic swelling behavior of gamma-radiation induced polyelectrolyte poly(AAm-co-CA) hydrogels in urea solutions.

    abstract：:The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.026

    authors： Karadağ E,Uzüm OB,Saraydin D,Güven O

    更新日期：2005-09-14 00:00:00

  • In-situ single pass intestinal permeability and pharmacokinetic study of developed Lumefantrine loaded solid lipid nanoparticles.

    abstract：:The present investigation aims to develop lumefantrine loaded binary solid lipid nanoparticles (LF-SLNs) to improve its poor and variable oral bioavailability. The oral bioavailability of LF is poor and variable due to its limited aqueous solubility and P-gp mediated efflux occurring in small intestine. LF-SLNs were p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.064

    authors： Garg A,Bhalala K,Tomar DS,Wahajuddin

    更新日期：2017-01-10 00:00:00

  • In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes.

    abstract：:The purpose of this study was to investigate the effect of heparin conjugation to the surface of doxorubicin (DOX)-loaded liposomes on the circulation time, biodistribution and antitumor activity after intravenous injection in murine B16F10 melanoma tumor-bearing mice. The heparin-conjugated liposomes (heparin-liposom...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.007

    authors： Han HD,Lee A,Song CK,Hwang T,Seong H,Lee CO,Shin BC

    更新日期：2006-04-26 00:00:00

  • In vitro and in silico characterization of fibrous scaffolds comprising alternate colistin sulfate-loaded and heat-treated polyvinyl alcohol nanofibrous sheets.

    abstract：:A multilayer mat for dispensing colistin sulfate through a body surface was prepared by electrospinning. The fabricated system comprised various polyvinyl alcohol fibrous layers prepared with or without the active ingredient. One of the electrospun layers contained water-soluble colistin sulfate and the other was prep...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.03.044

    authors： Sebe I,Ostorházi E,Bodai Z,Eke Z,Szakács J,Kovács NK,Zelkó R

    更新日期：2017-05-15 00:00:00

  • Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells.

    abstract：:Many studies have demonstrated the uptake mechanisms of various nanoparticle delivery systems with different physicochemical properties in different cells. In this study, we report for the first time the preparation and characterization of teniposide (VM-26) poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) an...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.050

    authors： Mo L,Hou L,Guo D,Xiao X,Mao P,Yang X

    更新日期：2012-10-15 00:00:00

  • A prototype 'Infucon' device for continuous infusion of microbubbles in vivo.

    abstract：:A device for continuous infusion of microbubbles (MBs) 'Infucon' has been designed, constructed and tested on rabbits. The device prevents MBs from flotation and accumulation in the layer directly below the surface in the syringe injection during i.v. application. Homogenous i.v. application of MBs was tested on 16 ma...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.12.026

    authors： Kauerová Z,Lukáč R,Kohout P,Mašek J,Koudelka Š,Plocková J,Vašíčková M,Vlašín M,Turánek J

    更新日期：2013-01-30 00:00:00

  • Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics.

    abstract：:A substantial drug release from poly(lactic-co-glycolic) acid (PLGA) micro- and nanoparticles can occur in the first hours of immersion, which is referred to as burst release. A strong burst release (when not intentional) is to be avoided as it decreases the efficacy of the treatment and could be dangerous to the host...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.08.118

    authors： Rodrigues de Azevedo C,von Stosch M,Costa MS,Ramos AM,Cardoso MM,Danhier F,Préat V,Oliveira R

    更新日期：2017-10-30 00:00:00

  • Hydrodynamic size characterization of a self-emulsifying lipid pharmaceutical excipient by Taylor dispersion analysis with fluorescent detection.

    abstract：:In this work, the sizing of microemulsion droplets of a lipid-based pharmaceutical excipient (Labrasol® ALF) is performed by Taylor dispersion analysis (TDA) using fluorescent detection. An hydrophobic fluorescent marker is used to tag the microemulsion droplet and to increase the sensitivity of detection (compared to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.09.016

    authors： Chamieh J,Jannin V,Demarne F,Cottet H

    更新日期：2016-11-20 00:00:00

  • Brain targeted delivery of carmustine using solid lipid nanoparticles modified with tamoxifen and lactoferrin for antitumor proliferation.

    abstract：:Solid lipid nanoparticles (SLNs) conjugated with tamoxifen (TX) and lactoferrin (Lf) were applied to carry anticancer carmustine (BCNU) across the blood-brain barrier (BBB) for enhanced antiproliferation against glioblastoma multiforme (GBM). BCNU-loaded SLNs with modified TX and Lf (TX-Lf-BCNU-SLNs) were used to pene...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.12.054

    authors： Kuo YC,Cheng SJ

    更新日期：2016-02-29 00:00:00

  • Effect of adsorbents on the absorption of lansoprazole with surfactant.

    abstract：:Lansoprazole (LPZ) is a representative drug that shows a high inter-subject variation of bioavailability (BA). Solid preparation composed of surfactant, adsorbent and LPZ were prepared to improve the dissolution and absorption of LPZ, and the BA of LPZ was measured in rats and dogs. As surfactant, Tween 80, polyoxy 60...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.10.010

    authors： Ito Y,Arai H,Uchino K,Iwasaki K,Shibata N,Takada K

    更新日期：2005-01-31 00:00:00

  • Taste sensing systems (electronic tongues) for pharmaceutical applications.

    abstract：:Electronic tongues are sensor array systems able to detect single substances as well as complex mixtures by means of particular sensor membranes and electrochemical techniques. Two systems are already commercially available, the Insent taste sensing system and the αAstree electronic tongue. In addition, various labora...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2010.11.028

    authors： Woertz K,Tissen C,Kleinebudde P,Breitkreutz J

    更新日期：2011-09-30 00:00:00

  • The relevance of nitrendipine erythrocyte partitioning for the variability of its bioavailability parameters.

    abstract：:The pharmacokinetic parameters of nitrendipine were determined in 40 healthy male volunteers and a very high degree of intersubject variability was observed (CV = 39-71%). Since the distribution of nitrendipine to erythrocytes could influence the overall pharmacokinetic variability the correlation between hematocrit a...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0378-5173(00)00683-9

    authors： Antolic G,Kozjek F,Primozic S

    更新日期：2001-03-14 00:00:00

  • Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor.

    abstract：:It is well acknowledged that oral bioavailability of a drug candidate is often influenced by factors such as the permeability, physico-chemical properties, and metabolism of the drug. Among the physico-chemical properties, solubility and dissolution rate are considered the most critical factors affecting the oral bioa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.06.064

    authors： Cui Y,Chiang PC,Choo EF,Boggs J,Rudolph J,Grina J,Wenglowsky S,Ran Y

    更新日期：2013-09-15 00:00:00

  • Design of a dissolution system for the evaluation of the release rate characteristics of artemether and dihydroartemisinin from tablets.

    abstract：:As none of the pharmacopoeial dissolution methods are suitable to evaluate the release rate of artemether and dihydroartemisinin from tablets, a 'two-phase partition-dissolution' method, based on the one of [J. Pharm. Sci. 85 (1996) 1060] was developed. It consists of an organic solvent in the upper part and the aqueo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.022

    authors： Gabriëls M,Plaizier-Vercammen J

    更新日期：2004-04-15 00:00:00

  • The influence of the physicochemical characteristics and pharmacokinetic properties of selected NSAID's on their transdermal absorption.

    abstract：:The purpose of this study was to determine the plasma concentrations of selected NSAIDs after topical gel administration and to determine the influence of the physicochemical characteristics of these drugs on transdermal absorption. Plasma concentrations of the drugs were determined using high performance liquid chrom...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00340-3

    authors： Beetge E,du Plessis J,Müller DG,Goosen C,van Rensburg FJ

    更新日期：2000-01-05 00:00:00

  • Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN).

    abstract：:Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinit...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.02.005

    authors： Souto EB,Anselmi C,Centini M,Müller RH

    更新日期：2005-05-13 00:00:00

  • Response surface methodology as a predictive tool for determining the effects of preparation conditions on the physicochemical properties of poly(isobutylcyanoacrylate) nanoparticles.

    abstract：:Preparation conditions of nanoparticles greatly influence their physicochemical characteristics. A factorial design was used to evaluate the influence of these conditions on the particle diameter, zeta potential, polydispersity, percentage recovery, and molecular weight of poly(isobutylcyanoacrylate) nanoparticles. Th...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00311-7

    authors： McCarron PA,Woolfson AD,Keating SM

    更新日期：1999-12-20 00:00:00

  • Development of enteric polymer-based microspheres by spray-drying for colonic delivery of Lactobacillus rhamnosus GG.

    abstract：:Antibiotics are well-known disruptive elements of the intestinal microbiota and antibiotic-associated diarrhea appeared as the most common complication related with post-antibiotic dysbiosis. Lactobacillus rhamnosus GG (LGG) strain is very effective in preventing antibiotic-associated diarrhea in children and adults. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119414

    authors： Akanny E,Bourgeois S,Bonhommé A,Commun C,Doleans-Jordheim A,Bessueille F,Bordes C

    更新日期：2020-06-30 00:00:00