Abstract：
:The aim of this study was to investigate the equilibrium swelling properties in urea solutions of gamma-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide-co-crotonic acid), poly(AAm-co-CA) hydrogels containing different amounts of CA were obtained in the form of rods after radiation. Swelling experiments were performed in aqueous urea solutions at 25 degrees C, gravimetrically. The hydrogels showed large extents of swelling in aqueous (urea/water) media the swelling being highly dependent on the chemical composition of the hydrogels and irradiation dose. The percentage swelling of poly(AAm-co-CA) hydrogels was between 1160 and 4250%, while that of the AAm hydrogels was between 670 and 900%. The diffusional exponent values (n) are between 0.51 and 0.66, hence the diffusion of urea/water into the hydrogels is non-Fickian. Equilibrium urea/water contents of the hydrogel systems were changed between 0.870 and 0.977.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Karadağ E,Uzüm OB,Saraydin D,Güven Odoi
10.1016/j.ijpharm.2005.05.026keywords:
subject
Has Abstractpub_date
2005-09-14 00:00:00pages
102-11issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(05)00336-4journal_volume
301pub_type
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