当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Suppression of agglomeration in fluidized bed coating. II. Measurement of mist size in a fluidized bed chamber and effect of sodium chloride addition on mist size.

Suppression of agglomeration in fluidized bed coating. II. Measurement of mist size in a fluidized bed chamber and effect of sodium chloride addition on mist size.

Abstract：

:It has been reported that the degree of particle agglomeration in fluidized bed coating is greatly affected by the spray mist size of coating solution. However, the mist size has generally been measured in open air, and few reports have described the measurement of the mist size in a chamber of the fluidized bed, in which actual coating is carried out. Therefore, using hydroxypropylmethyl cellulose (HPMC) aqueous solution as a coating solution, the spray mist size of the coating solution in a chamber of the fluidized bed was measured under various coating conditions, such as the distance from the spray nozzle, fluidization air volume, inlet air temperature and addition of sodium chloride (NaCl) into the coating solution. The mist size in the fluidized bed was compared with that in open air at various distances from the spray nozzle. Further, the relationship between the spray mist size and the degree of suppression of agglomeration at various NaCl concentrations during fluidized bed coating was studied. The mist size distribution showed a logarithmic normal distribution in both cases of the fluidized bed and open air. The number-basis median diameter of spray mist (D50) in the fluidized bed was smaller compared with that in open air. D50 increased with the increasing distance from the spray nozzle in both cases. In the fluidized bed, D50 decreased with the increasing fluidization air volume and inlet air temperature. The effect of NaCl concentration on the mist size was hardly observed, but the degree of suppression of agglomeration during coating increased with the increasing NaCl concentration in the coating solution.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Yuasa H,Nakano T,Kanaya Y

doi

10.1016/s0378-5173(98)00370-6

keywords:

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

1-10

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(98)00370-6

journal_volume

178

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Polymorphs and pharmacokinetics of an antipsychotic drug candidate.

    abstract：:A potent antipsychotic drug candidate, 7-(4-(4-(6-fluorobenzo[d]-isoxazol-3-yl)-piperidin-1-yl)butoxy)-4-methyl-8-chloro -2H-chromen-2-one mesylate(CY611), with good in vitro and in vivo antipsychotic effects was investigated for preformulation evaluation by crystallography methods. Three anhydrous polymorphs(Form I-I...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119600

    authors： Hao C,Chen Y,Xiong J,Yang Z,Gao L,Liu BF,Liu X,Jin J,Zhang G

    更新日期：2020-08-30 00:00:00

  • Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant physically mixed or incorporated.

    abstract：:In a previous study, it was shown that the incorporation of poorly soluble drugs (BCS class II) in sugar glasses could largely increase the drug's dissolution rate [van Drooge, D.J., Hinrichs, W.L.J., Frijlink, H.W., 2004 b. Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.07.023

    authors： de Waard H,Hinrichs WL,Visser MR,Bologna C,Frijlink HW

    更新日期：2008-02-12 00:00:00

  • Formation, characterization and pH dependence of rifampicin: heptakis(2,6-di-O-methyl)-β-cyclodextrin complexes.

    abstract：:Rifampicin (Rif) is a broad spectrum antibiotic used as a first line agent in the treatment of mycobacterial infections. However, its low solubility and reduced stability in water limit its bioavailability, thus requiring the use of complex formulations. Here, we present a systematic study of Rif in complex with a met...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.06.015

    authors： Angiolini L,Agnes M,Cohen B,Yannakopoulou K,Douhal A

    更新日期：2017-10-15 00:00:00

  • Development of a new method to characterize (SMBV) antigen formulations using surface plasmon resonance technology.

    abstract：:Supra Molecular Biovectors (SMBV) are nanoparticles composed by a polysaccharidic core surrounded by a lipid bilayer. They are designed for drug delivery and vaccine and can be administrated by nasal route. The association rate and the stability of association between active principle (AP) or antigens (Ag) with SMBV c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00227-2

    authors： Siguier JP,Major M,Balland O

    更新日期：2002-08-21 00:00:00

  • Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging.

    abstract：:Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be used for a variety of purposes, from classification (and sorting) of products to mapping spatial distribution of materials. The present study examined if NIR-CI is suitable for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.12.003

    authors： Wahl PR,Pucher I,Scheibelhofer O,Kerschhaggl M,Sacher S,Khinast JG

    更新日期：2017-02-25 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract：:Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.05.001

    authors： Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期：2014-08-25 00:00:00

  • Validation of fluid bed granulation utilizing artificial neural network.

    abstract：:Three innovative components (an annular gap spray system, a booster bottom and an outlet filter) have been developed by Innojet Technologies to improve fluid bed technology and to reduce the common interference factors (clogging of nozzles and outlet filters, spray loss, spray drying and fluidized bed heterogeneity). ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.07.051

    authors： Behzadi SS,Klocker J,Hüttlin H,Wolschann P,Viernstein H

    更新日期：2005-03-03 00:00:00

  • Formulation, stability and degradation kinetics of intravenous cinnarizine lipid emulsion.

    abstract：:Cinnarizine was loaded in the lipid emulsion to develop an intravenous formulation with good physical and chemical stability. High-pressure homogenization was used to prepare the lipid emulsion. The factors influencing the stability of cinnarizine lipid emulsion, such as different drug loading methods, pH, temperature...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.02.006

    authors： Shi S,Chen H,Cui Y,Tang X

    更新日期：2009-05-21 00:00:00

  • Effect of electrokinetic stabilizers on the physicochemical properties of propofol emulsions.

    abstract：:The aims of the present study were to elucidate the potential mechanism of propofol emulsion destabilization following the addition of lidocaine, and to evaluate the effects of various electrokinetic stabilizers on the physicochemical properties of lidocaine-propofol emulsions. The assessments included pH observations...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.07.011

    authors： Rhee YS,Park CW,Oh TO,Kim JY,Ha JM,Lee BJ,Lee KH,Chi SC,Park ES

    更新日期：2010-10-15 00:00:00

  • Evaluation of collagen and methylated collagen as gene carriers.

    abstract：:This study explores the potential of DNA complexes prepared with methylated collagen (MC) and unmodified native collagen (NC) to deliver genes into cells. The physicochemical properties and transfection abilities of these two types of complexes are studied in parallel. MC was prepared by methylation of the carboxyl gr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.04.014

    authors： Wang J,Lee IL,Lim WS,Chia SM,Yu H,Leong KW,Mao HQ

    更新日期：2004-07-26 00:00:00

  • Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking.

    abstract：:Microspheres of roxithromycin with Eudragit S100 and silica were prepared by the emulsion solvent diffusion method to mask the bitter taste of the antibiotic. The effect of different polymers and drug-polymer ratios on the taste masking and the characteristics of the microspheres were investigated. It was found that E...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.03.018

    authors： Gao Y,Cui FD,Guan Y,Yang L,Wang YS,Zhang LN

    更新日期：2006-08-02 00:00:00

  • A pharmaceutical study of doxorubicin-loaded PEGylated nanoparticles for magnetic drug targeting.

    abstract：:One of the new strategies to improve cancer chemotherapy is based on new drug delivery systems, like the polyethylene glycol-coated superparamagnetic iron oxide nanoparticles (PEG-SPION, thereafter called PS). In this study, PS are loaded with doxorubicin (DOX) anticancer drug, using a pre-formed DOX-Fe(2+) complex re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.06.010

    authors： Gautier J,Munnier E,Paillard A,Hervé K,Douziech-Eyrolles L,Soucé M,Dubois P,Chourpa I

    更新日期：2012-02-14 00:00:00

  • TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa.

    abstract：:The objective of the present study was to evaluate the TR146 cell culture model as an in vitro model of human buccal epithelium. For this purpose, the permeability of water, mannitol and testosterone across the TR146 cell culture model was compared to the permeability across human, monkey and porcine buccal mucosa. Fu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00368-3

    authors： Nielsen HM,Rassing MR

    更新日期：2000-01-25 00:00:00

  • Preliminary evaluation of a novel oral delivery system for rhPTH1-34: in vitro and in vivo.

    abstract：:rhPTH1-34 is clinically used for osteoporosis treatment. However, this peptide drug has no oral bioavailability because of proteolysis and low membrane permeability in gastrointestinal gut. This study explored the possibility of absorption enhancement for rhPTH1-34 through the oral delivery of the microemulsion. The m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.08.029

    authors： Guo L,Ma E,Zhao H,Long Y,Zheng C,Duan M

    更新日期：2011-11-25 00:00:00

  • Encapsulation of azithromycin into polymeric microspheres by reduced pressure-solvent evaporation method.

    abstract：:Azithromycin loaded microspheres with blends of poly-l-lactide and ploy-D,L-lactide-co-glycolide as matrices were prepared by the atmosphere-solvent evaporation (ASE) and reduced pressure-solvent evaporation (RSE) method. Both the X-ray diffraction spectra and DSC thermographs demonstrated that poly-L-lactide existed ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.081

    authors： Li X,Chang S,Du G,Li Y,Gong J,Yang M,Wei Z

    更新日期：2012-08-20 00:00:00

  • Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations.

    abstract：:Spray drying can be utilized to produce highly dispersible powder aerosol formulations. However, these formulations are known to be hygroscopic, leading to potential solid-state stability and aerosol performance issues. This study aims to investigate if control of the spray drying particle formation conditions could b...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.120027

    authors： Hassan A,Farkas D,Longest W,Hindle M

    更新日期：2020-12-15 00:00:00

  • An investigation into interactions between polyacrylic polymers and a non-ionic surfactant: an emulsion preformulation study.

    abstract：:The aim of this study was to investigate possible interactions between a polymeric emulsifier and a non-ionic surfactant, with a view of achieving better understanding of emulsion stabilisation mechanisms. The polymeric emulsifier used was acrylates/C10-30 alkyl acrylate crosspolymer (Pemulen TR-2(R)), while Polyoxyet...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00097-6

    authors： Simovic S,Tamburic S,Milic-Askrabic J,Rajic D

    更新日期：1999-07-20 00:00:00

  • In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes.

    abstract：:The purpose of this study was to investigate the effect of heparin conjugation to the surface of doxorubicin (DOX)-loaded liposomes on the circulation time, biodistribution and antitumor activity after intravenous injection in murine B16F10 melanoma tumor-bearing mice. The heparin-conjugated liposomes (heparin-liposom...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.007

    authors： Han HD,Lee A,Song CK,Hwang T,Seong H,Lee CO,Shin BC

    更新日期：2006-04-26 00:00:00

  • Hydrogel based approaches for cardiac tissue engineering.

    abstract：:Heart failure still represents the leading cause of death worldwide. Novel strategies using stem cells and growth factors have been investigated for effective cardiac tissue regeneration and heart function recovery. However, some major challenges limit their translation to the clinic. Recently, biomaterials have emerg...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2016.10.061

    authors： Saludas L,Pascual-Gil S,Prósper F,Garbayo E,Blanco-Prieto M

    更新日期：2017-05-25 00:00:00

  • A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles.

    abstract：:Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed betwee...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.08.070

    authors： Zariwala MG,Elsaid N,Jackson TL,Corral López F,Farnaud S,Somavarapu S,Renshaw D

    更新日期：2013-11-18 00:00:00

  • Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery.

    abstract：:Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.05.005

    authors： Callender SP,Mathews JA,Kobernyk K,Wettig SD

    更新日期：2017-06-30 00:00:00

  • Deoxycholate-hydrogels: novel drug carrier systems for topical use.

    abstract：:Na-deoxycholate (Na-DOC) forms a viscous thixotropic gel when in contact with excess buffer systems. The resulting gels have been tested as novel drug carrier systems for topical use. The influence of differing amounts of mannitol, glycerol and xylitol on the viscous modulus (G"/Pa) was evaluated by oscillatory measur...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00170-2

    authors： Valenta C,Nowack E,Bernkop-Schnürch A

    更新日期：1999-08-05 00:00:00

  • Development of PMMA membranes functionalized with hydroxypropyl-beta-cyclodextrins for controlled drug delivery using a supercritical CO(2)-assisted technology.

    abstract：:Cyclodextrin-containing polymers have proved themselves to be useful for controlled release. Herein we describe the preparation of membranes of poly(methylmethacrylate) (PMMA) containing hydroxypropyl-beta-cyclodextrins (HP-beta-CDs) using a supercritical CO(2)-assisted phase inversion method, for potential applicatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.029

    authors： Temtem M,Pompeu D,Jaraquemada G,Cabrita EJ,Casimiro T,Aguiar-Ricardo A

    更新日期：2009-07-06 00:00:00

  • Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs.

    abstract：:The objective of this study was to develop a novel fenofibric acid-loaded controlled release pellet showing enhanced, or equivalent to, bioavailability compared with two commercially available products containing fenofibrate or choline fenofibrate. The effect of solubilizing agents on drug solubility and the impact of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.059

    authors： Kim KS,Jin SG,Mustapha O,Yousaf AM,Kim DW,Kim YH,Kim JO,Yong CS,Woo JS,Choi HG

    更新日期：2015-07-25 00:00:00

  • Chitosan and its derivatives: potential excipients for peroral peptide delivery systems.

    abstract：:In the 1990s chitosan turned out to be a useful excipient in various pharmaceutical formulations. By modifications of the primary amino group at the 2-position of this poly(beta1-->4 D-glucosamine), the features of chitosan can even be optimised according to a given task in drug delivery systems. For peroral peptide d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-5173(99)00365-8

    authors： Bernkop-Schnürch A

    更新日期：2000-01-20 00:00:00

  • Application of continuous twin screw granulation for the metformin hydrochloride extended release formulation.

    abstract：:This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel tempe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.019

    authors： Kim SH,Hwang KM,Cho CH,Nguyen TT,Seok SH,Hwang KM,Kim JY,Park CW,Rhee YS,Park ES

    更新日期：2017-08-30 00:00:00

  • The use of colloidal microgels as a (trans)dermal drug delivery system.

    abstract：:A co-polymer of poly(N-isopropylacrylamide) (85%) co-butyl acrylate (10%) co-methacrylic acid (5%) (NIPAM/BA/MAA) (85/10/5) microgel was synthesised and investigated as a potential pH and temperature sensitive transdermal delivery device. Three compounds having different octanol/water partition coefficients and solubi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.040

    authors： Lopez VC,Hadgraft J,Snowden MJ

    更新日期：2005-03-23 00:00:00

  • Poloxamer-based solid dispersions for oral delivery of docetaxel: Differential effects of F68 and P85 on oral docetaxel bioavailability.

    abstract：:Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.002

    authors： Song CK,Yoon IS,Kim DD

    更新日期：2016-06-30 00:00:00

  • Swelling, melting point reduction and solubility of PEG 1500 in supercritical CO2.

    abstract：:The knowledge of the solubility of PEG 1500 as well as the swelling and melting point variation in supercritical CO(2) in a relatively high-pressure range is a necessary prerequisite to set-up pharmaceutical processes dealing with the polymer in the molten state. Experiments carried out in a pressurized view cell indi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.048

    authors： Pasquali I,Comi L,Pucciarelli F,Bettini R

    更新日期：2008-05-22 00:00:00

  • Lactose-ornithine bolaamphiphiles for efficient gene delivery in vitro.

    abstract：:The development of new nonviral vectors characterized by high transfection efficiency and low cytotoxicity remains an important challenge in the field of gene delivery. Unsymmetrical bolaamphiphiles (bolas) appear as new emerging candidates for this application. In this work, new unsymmetrical bolas, bearing neutral l...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.12.026

    authors： Jain N,Goldschmidt V,Oncul S,Arntz Y,Duportail G,Mély Y,Klymchenko AS

    更新日期：2012-02-28 00:00:00