Abstract：
:Microspheres of roxithromycin with Eudragit S100 and silica were prepared by the emulsion solvent diffusion method to mask the bitter taste of the antibiotic. The effect of different polymers and drug-polymer ratios on the taste masking and the characteristics of the microspheres were investigated. It was found that Eudragit S100 was the best for masking the unpleasant taste of roxithromycin among the six kinds of polymers investigated. The results of DSC, X-ray diffraction and IR showed that there were several combinations of roxithromycin and Eudragit S100. The influence of other formulation factors, i.e. dichloromethane-acetone ratios and silica-polymer ratios on the properties of the microspheres were also examined. In conclusion, the results of the present study will be helpful for the preparation of oral forms of roxithromycin with an acceptable taste.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Gao Y,Cui FD,Guan Y,Yang L,Wang YS,Zhang LNdoi
10.1016/j.ijpharm.2006.03.018subject
Has Abstractpub_date
2006-08-02 00:00:00pages
62-9issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00236-5journal_volume
318pub_type
杂志文章abstract：:The vitamin E analogue, α-tocopherol succinate (α-TOS), has a broad anti-tumor effect. α-TOS can induce cancer cells apoptosis and suppress tumor growth by targeting mitochondria. Low bioavailability of α-TOS is the major problem encountered with formulation development. In our study, α-TOS nanoemulsion (α-TOS-NE) was...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2016.10.026
更新日期：2016-12-30 00:00:00
abstract：:The kinetics of fenoprofen release from poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-fenoprofen conjugate (PHEA-Fen) in aqueous buffer solutions (pH 10 and 1.1), simulated gastric (SGF) and intestinal fluids (SIF) was studied. In borate buffer pH 10, the following rate constants were obtained: k=0.2659 (t=60 deg...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/s0378-5173(02)00197-7
更新日期：2002-07-25 00:00:00
abstract：:The aim of this work was to evaluate the suitability of stereolithography (SLA) to fabricate drug-loaded tablets with modified-release characteristics. The SLA printer creates solid objects by using a laser beam to photopolymerise monomers. In this work polyethylene glycol diacrylate (PEGDA) was used as a monomer and ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2016.03.016
更新日期：2016-04-30 00:00:00
abstract：:Pulmonary hypertension (PAH) is a condition of the lungs characterised by an elevated arterial pressure and increased vascular resistance. Existing medications have to be administered frequently, resulting in non compliance by patients. Little work has been reported to date where microspheres have been developed to co...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.04.011
更新日期：2013-06-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2002-09-05 00:00:00
abstract：:Photothermal therapy had great potential in being a new approach of tumour ablation due to their high selectivity and low side effect. However, the shallow penetration depth of near-infrared (NIR) irradiation resulted in the limited curative effect. Herein, a novel nanomedicine was developed based on the indocyanine g...
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/s0378-5173(01)00919-x
更新日期：2002-02-21 00:00:00
abstract：:To ensure success in the development and manufacturing of nanomedicines requires forces of an interdisciplinary team that combines medicine, engineering, chemistry, biology, material and pharmaceutical areas. Numerous researches in nanotechnology applied to human health are available in the literature. Althought, the ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
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更新日期：2019-09-10 00:00:00
abstract：:Endothelium is an important target for drug or gene therapy because of its important role in the biological system. In this paper, we have characterized nanoparticle uptake by endothelial cells in cell culture. Nanoparticles were formulated using poly DL-lactide-co-glycolide polymer containing bovine serum albumin as ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2002-02-21 00:00:00
abstract：:11-Keto-β-boswellic acid (KBA) is an important and potent boswellic acids responsible for anti-inflammatory action of Boswellia extract. However, its pharmaceutical development has been severely limited by its poor oral bioavailability. The present work aims to investigate the permeability related hurdles in oral deli...
journal_title：International journal of pharmaceutics
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更新日期：2014-04-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2019-12-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2018-10-25 00:00:00
abstract：:Naltrexone hydrochloride (NTX) is a promising treatment for corneal disorders linked to diabetes mellitus (diabetic keratopathy). However, NTX has a major stability problem due to autoxidation, which is likely to hinder its formulation as eye drops for treatment of diabetic keratopathy. In this study, in-house develop...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2012.05.011
更新日期：2012-08-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 临床试验,杂志文章
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更新日期：2004-05-19 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2018.04.048
更新日期：2018-07-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2010-03-15 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2007-09-05 00:00:00
abstract：:Personalized medicine is a challenging research area in paediatric treatments. Elaborating new paediatric formulations when no commercial forms are available is a common practice in pharmacy laboratories; among these, oral liquid formulations are the most common. But due to the lack of specialized equipment, frequentl...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2014-01-02 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2011.01.023
更新日期：2011-04-04 00:00:00
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pub_type： 杂志文章
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更新日期：2019-10-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2020-01-25 00:00:00
abstract：:The influence of temperature, pH, keratinase concentration, substrate concentration and incubation time on the soluble proteins released by a new keratinase from Doratomyces microsporus was studied with a second-order experimental design. Only 15 or 18 spectrophotometric analyses were required to determine the optimal...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2001-08-14 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2011-01-17 00:00:00
abstract：:The purpose of this study was to develop a novel featured and flexible methotrexate (MTX) formulation, in which MTX was physically entrapped and chemically conjugated in the same drug delivery system. A series of poloxamer-MTX (p-MTX) conjugates was synthesized, wherein MTX was grafted to poloxamer through an ester bo...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2015.04.014
更新日期：2015-06-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2014.05.009
更新日期：2014-08-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2014.01.033
更新日期：2014-04-25 00:00:00
