Abstract：
:Nanoparticles of polymeric complexes made of hyaluronic acid and polyarginine were investigated for the encapsulation of the cationic hydrophilic drug pentamidine isethionate. The interaction between the anionic hyaluronic acid and the cationic pentamidine resulting in the formation of polyelectrolyte complexes was firstly studied. Then, nanoparticles made of hyaluronic acid and polyarginine loaded with pentamidine were developed. These drug delivery systems consist of a monodisperse population of negatively charged pentamidine-loaded nanoparticles with a high drug encapsulation rate (80%). Such high encapsulation efficiency coming from ion exchange was confirmed by measurements of the counterion isethionate released from pentamidine during nanoparticles formation. Besides, freeze-dried pentamidine-loaded nanoparticles kept their integrity after their reconstitution in water. In vitro studies on human lung (A549) and breast (MDA-MB-231) cancer cell lines showed that pentamidine-loaded nanoparticles were more cytotoxic in comparison to the free drug, suggesting an enhanced internalization of encapsulated drug by cancer cells.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Carton F,Chevalier Y,Nicoletti L,Tarnowska M,Stella B,Arpicco S,Malatesta M,Jordheim LP,Briançon S,Lollo Gdoi
10.1016/j.ijpharm.2019.118526subject
Has Abstractpub_date
2019-09-10 00:00:00pages
118526eissn
0378-5173issn
1873-3476pii
S0378-5173(19)30570-8journal_volume
568pub_type
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