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Macromolecular prodrugs: X. Kinetics of fenoprofen release from PHEA-fenoprofen conjugate.

Abstract：

:The kinetics of fenoprofen release from poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-fenoprofen conjugate (PHEA-Fen) in aqueous buffer solutions (pH 10 and 1.1), simulated gastric (SGF) and intestinal fluids (SIF) was studied. In borate buffer pH 10, the following rate constants were obtained: k=0.2659 (t=60 degrees C) and k=0.0177 h(-1) (t=37 degrees C) and in glycine buffer solution pH 1.1 k=0.0036 h(-1). In SGF and SIF fenoprofen release did not occur in significant extend within 12 h. The hydrolysis of the ester bond between the polymeric carrier and fenoprofen followed the pseudo first-order kinetics, with activation energy indicative for the breakage of a sigma bond (E(a)=100.6 kJ mol(-1)). The concentration of the released fenoprofen was determined by high performance liquid chromatography (HPLC).

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

van der Merwe T,Boneschans B,Zorc B,Breytenbach J,Zovko M

doi

10.1016/s0378-5173(02)00197-7

keywords:

subject

Has Abstract

pub_date

2002-07-25 00:00:00

pages

223-30

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378517302001977

journal_volume

241

pub_type

杂志文章

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