Abstract：
:A gastroretentive drug delivery system of DA-6034, a new synthetic flavonoid derivative, for the treatment of gastritis was developed by using effervescent floating matrix system (EFMS). The therapeutic limitations of DA-6034 caused by its low solubility in acidic conditions were overcome by using the EFMS, which was designed to cause tablets to float in gastric fluid and release the drug continuously. The release of DA-6034 from tablets in acidic media was significantly improved by using EFMS, which is attributed to the effect of the solubilizers and the alkalizing agent such as sodium bicarbonate used as gas generating agent. DA-6034 EFMS tablets showed enhanced gastroprotective effects in gastric ulcer-induced beagle dogs, indicating the therapeutic potential of EFMS tablets for the treatment of gastritis.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Jang SW,Lee JW,Park SH,Kim JH,Yoo M,Na DH,Lee KCdoi
10.1016/j.ijpharm.2007.12.042subject
Has Abstractpub_date
2008-05-22 00:00:00pages
88-94issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(08)00006-9journal_volume
356pub_type
杂志文章abstract：:The aims of this study were to examine the phase behavior of itraconazole-phenol mixtures and assess the feasibility of topical formulations of itraconazole using eutectic mixture systems. Itraconazole-phenol eutectic mixtures were characterized using differential scanning calorimetry, Fourier transform infrared spect...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2012-10-15 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2017-12-20 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2019-01-10 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2006-04-07 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2013-06-25 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2003-05-12 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2001-05-07 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2004.11.034
更新日期：2005-03-23 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2004-08-20 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2019-04-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2001-02-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2011.04.054
更新日期：2012-02-14 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2013-01-20 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：1999-06-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2011-09-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2018-09-05 00:00:00
abstract：:RNA interfere (RNAi)-based technology holds great promise in cancer treatment. The use of small interfering RNA (siRNA), however, is hampered by its low delivery efficiency in vivo when they are diluted in blood biofluids and in the presence of serum and salt. In this study, we developed the polyglutamate derivative p...
journal_title：International journal of pharmaceutics
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更新日期：2016-05-30 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2018-08-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2013-12-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2016-06-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
doi：10.1016/j.ijpharm.2020.120081
更新日期：2021-01-05 00:00:00
