Abstract：
:Changes in the rheological properties of four o/w cream formulations differing in the combination of surfactants were studied. The non-ionic surfactants used were soybean derivatives, polyethylene glycol 10 and 25 soya sterol, and sorbitol derivatives, sorbitan monooleate and trioleate. Combinations of the soybean and sorbitol derivatives were used. The rheological properties were tested during a 28-day storage period at three different storage conditions (cold, room temperature and accelerated conditions). In addition to dynamic and static rheological tests, droplet size distributions and conductivities of the creams were also determined. The consistency of the creams containing polyethylene glycol 10 soya sterol decreased during storage. Despite the greatest decreases in consistency, the creams containing polyethylene glycol 10 soya sterol exhibited the most viscoelastic structures with linear viscoelastic behaviour. Storing the creams for 28 days in the three different storage conditions made the differences in the consistency of the formulations smaller. All three storage conditions were involved when the conditions of the most viscoelastic cream of each formulation was specified. In the case of linearly viscoelastically behaving creams containing polyethylene glycol 10 soya sterol, all the rheological tests correlated with the droplet size distributions and the conductivity tests.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Korhonen M,Hellen L,Hirvonen J,Yliruusi Jdoi
10.1016/s0378-5173(01)00675-5keywords:
subject
Has Abstractpub_date
2001-06-19 00:00:00pages
187-96issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517301006755journal_volume
221pub_type
杂志文章abstract：:The stratum corneum possesses a very heterogenous structure. As such a diffusing molecule can access a number of different pathways. It is probable that the excellent barrier properties of the stratum corneum result from a tortuous diffusional pathway around the dead cells. However, there are considerable problems in ...
journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：1999-10-28 00:00:00
abstract：:Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both...
journal_title：International journal of pharmaceutics
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更新日期：2015-11-30 00:00:00
