3D printed medicines: A new branch of digital healthcare.

Abstract:

:Three-dimensional printing (3DP) is a highly disruptive technology with the potential to change the way pharmaceuticals are designed, prescribed and produced. Owing to its low cost, diversity, portability and simplicity, fused deposition modeling (FDM) is well suited to a multitude of pharmaceutical applications in digital health. Favourably, through the combination of digital and genomic technologies, FDM enables the remote fabrication of drug delivery systems from 3D models having unique shapes, sizes and dosages, enabling greater control over the release characteristics and hence bioavailability of medications. In turn, this system could accelerate the digital healthcare revolution, enabling medicines to be tailored to the individual needs of each patient on demand. To date, a variety of FDM 3D printed medical products (e.g. implants) have been commercialised for clinical use. However, within pharmaceuticals, certain regulatory hurdles still remain. This article reviews the current state-of-the-art in FDM technology for medical and pharmaceutical research, including its use for personalised treatments and interconnection within digital health networks. The outstanding challenges are also discussed, with a focus on the future developments that are required to facilitate its integration within pharmacies and hospitals.

journal_name

Int J Pharm

authors

Awad A,Trenfield SJ,Gaisford S,Basit AW

doi

10.1016/j.ijpharm.2018.07.024

subject

Has Abstract

pub_date

2018-09-05 00:00:00

pages

586-596

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30492-7

journal_volume

548

pub_type

杂志文章,评审
  • Sponges carrying self-microemulsifying drug delivery systems.

    abstract::Self-microemulsifying drug delivery systems (SMEDDS) increase the solubility of lipophilic drugs. One barrier to their wide application is their liquid nature. We report on a new method to solidify SMEDDS-their incorporation in sponges made from a hydrophilic natural polymer. Using different freeze-drying schemes, spo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2013.09.024

    authors: Josef E,Bianco-Peled H

    更新日期:2013-12-15 00:00:00

  • Key functions in polymer carriers for intestinal absorption of insulin.

    abstract::This work aimed to clarify the relationship between polymer function and insulin absorption, and to evaluate the optimized preparative formulation predicted from this relationship. Insulin-loaded polymer (ILP) carrier systems were prepared following a two-factor composite second-order spherical experimental design. To...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2007.10.050

    authors: Nakamura K,Morishita M,Ehara J,Onuki Y,Yamagata T,Kamei N,Lowman AM,Peppas NA,Takayma K

    更新日期:2008-04-16 00:00:00

  • Short-duration ocular iontophoresis of ionizable aciclovir prodrugs: A new approach to treat herpes simplex infections in the anterior and posterior segments of the eye.

    abstract::The objective was to investigate (trans)corneal and transscleral iontophoresis of biolabile amino acid ester prodrugs of aciclovir (ACV-X, X = Arg, Gly and Trp) as a means to increase ocular bioavailability of ACV. Prodrugs displayed tissue-dependent susceptibility to hydrolysis. Iontophoresis of ACV-Arg, ACV-Gly and ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2017.11.069

    authors: Chen Y,Kalia YN

    更新日期:2018-01-30 00:00:00

  • Colloidal particles containing labeling agents and cyclodextrins for theranostic applications.

    abstract::This review aims to give to the reader some new light on cyclodextrin (CD)-based theranostic agents in order to complete our recently published review dedicated to CD-particles conjugates in drug delivery systems (Zafar et al., 2014). CDs are biocompatible sugar-based macrocycles used in a wide range of biomedical app...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpharm.2014.06.004

    authors: Zafar N,Fessi H,Elaissari A

    更新日期:2014-09-10 00:00:00

  • Amino Acid-functionalized hollow mesoporous silica nanospheres as efficient biocompatible drug carriers for anticancer applications.

    abstract::Herein, a series of new amino acid-functionalized hollow mesoporous silica nanospheres (HMSNs) by post-grafting methods were prepared. These new materials were characterized by different techniques and were studied as matrices for the antineoplastic drug (cisplatin) transport and delivery. The results demonstrate that...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.118709

    authors: Ezzati N,Mahjoub AR,Abolhosseini Shahrnoy A,Syrgiannis Z

    更新日期:2019-12-15 00:00:00

  • The place of dosage form innovation and the OTC market: the price to pay.

    abstract:AIMS AND OBJECTIVES:The aims and objectives of this article are to provide a background to the innovations that are made in over the counter market and to outline the time and costs involved in these activities. ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2014.02.042

    authors: Goggin PL

    更新日期:2014-08-05 00:00:00

  • Influence of methyl-beta-cyclodextrin and liposomes on rheological properties of Carbopol 974P NF gels.

    abstract::The influence of positively-charged and sterically stabilized liposomes and/or methyl-beta-cyclodextrin on rheological properties of Carbopol 974P NF hydrogels was investigated. All formulations have displayed a shear-thinning behavior of Carbopol gels, and the rate stress as a function of the shear rate was fitted us...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(02)00683-x

    authors: Boulmedarat L,Grossiord JL,Fattal E,Bochot A

    更新日期:2003-03-18 00:00:00

  • Design, synthesis and evaluation of N-acetyl glucosamine (NAG)-PEG-doxorubicin targeted conjugates for anticancer delivery.

    abstract::Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates consisting N-acetyl glucosamine (NAG...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.05.078

    authors: Pawar SK,Badhwar AJ,Kharas F,Khandare JJ,Vavia PR

    更新日期:2012-10-15 00:00:00

  • Crystallization rate of amorphous nifedipine analogues unrelated to the glass transition temperature.

    abstract::To examine the relative contributions of molecular mobility and thermodynamic factor, the relationship between glass transition temperature (T(g)) and the crystallization rate was examined using amorphous dihydropyridines (nifedipine (NFD), m-nifedipine (m-NFD), nitrendipine (NTR) and nilvadipine (NLV)) with differing...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2006.11.052

    authors: Miyazaki T,Yoshioka S,Aso Y,Kawanishi T

    更新日期:2007-05-04 00:00:00

  • Polysaccharide-anchored fatty acid liposome.

    abstract::In this study, the preparation of N-pamitoyl chitosan (ChP) anchored oleic acid (OA) liposome was demonstrated. Two different types of water-soluble ChPs with different degrees of acylation (DA) were selected for this study. The presence of ChPs on the surface of OA liposome was confirmed with their micrographs and ph...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.11.013

    authors: Tan HW,Misran M

    更新日期:2013-01-30 00:00:00

  • Evaluation of alkyloxycarbonyloxymethyl (AOCOM) ethers as novel prodrugs of phenols for topical delivery: AOCOM prodrugs of acetaminophen.

    abstract::The maximum fluxes of a series of alkyloxycarbonyloxymethyl (AOCOM) ethers of acetaminophen (APAP) through hairless mouse skin from isopropyl myristate, IPM (J(MMIPM)) were measured. The J(MMIPM), solubilities in IPM (S(IPM)), water (S(AQ)) and pH 4.0 buffer (S4.0) and molecular weights MW were then fitted to the Robe...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2008.12.020

    authors: Thomas JD,Sloan KB

    更新日期:2009-04-17 00:00:00

  • Effect of drug lipophilicity on in vitro release rate from oil vehicles using nicotinic acid esters as model prodrug derivatives.

    abstract::The rate constants for transfer of a homologous series of nicotinic acid esters from oil vehicles to aqueous buffer phases were determined using a rotating dialysis cell. The chemical stability of butyl nicotinate has been investigated at 60 degrees C over pH range 0.5--10. Maximum stability occurs at pH 4--5 and an i...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(01)00568-3

    authors: Weng Larsen S,Engelbrecht Thomsen AE,Rinvar E,Friis GJ,Larsen C

    更新日期:2001-03-23 00:00:00

  • Targeted antifungal delivery system: beta-glucosidase sensitive nystatin-star poly(ethylene glycol) conjugate.

    abstract::A new targeted intravenous conjugate of nystatin with pentaerythritol poly(ethylene glycol)ether has been prepared and characterised (NY(4)-sPEG, M=25 160). The conjugate contains a beta-d-glucopyranoside molecular switch sensitive to beta-glucosidases (E.C.3.2.1.21), which are specifically present in the enzyme outfi...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2009.10.034

    authors: Bílková E,Imramovský A,Buchta V,Sedlák M

    更新日期:2010-02-15 00:00:00

  • Characterization of strain rate sensitivity in pharmaceutical materials using indentation creep analysis.

    abstract::Understanding how a material's response to stress changes as the stress is applied at different rates is important in predicting performance of pharmaceutical powders during tablet compression. Widely used methods for determining strain rate sensitivity (SRS) are empirically based and can often provide inconsistent or...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.09.006

    authors: Katz JM,Buckner IS

    更新日期:2013-02-14 00:00:00

  • Carrier mediated uptake of L-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)--strategy for the design of transporter/receptor targeted prodrugs.

    abstract::The objective of this study was to investigate the presence of amino acid transporters on the corneal epithelium and to enhance corneal drug absorption through prodrug modification targeted to the amino acid transporters. SIRC was used as a model cell line representing the corneal epithelium. Uptake studies were carri...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(02)00405-2

    authors: Balakrishnan A,Jain-Vakkalagadda B,Yang C,Pal D,Mitra AK

    更新日期:2002-10-24 00:00:00

  • Poloxamer-based solid dispersions for oral delivery of docetaxel: Differential effects of F68 and P85 on oral docetaxel bioavailability.

    abstract::Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2016.05.002

    authors: Song CK,Yoon IS,Kim DD

    更新日期:2016-06-30 00:00:00

  • Sustained release ophthalmic dexamethasone: In vitro in vivo correlations derived from the PK-Eye.

    abstract::Corticosteroids have long been used to treat intraocular inflammation by intravitreal injection. We describe dexamethasone loaded poly-DL-lactide-co-glycolide (PLGA) microparticles that were fabricated by thermally induced phase separation (TIPS). The dexamethasone loaded microparticles were evaluated using a two-comp...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2017.02.047

    authors: Awwad S,Day RM,Khaw PT,Brocchini S,Fadda HM

    更新日期:2017-04-30 00:00:00

  • Porous clay heterostructures: A new inorganic host for 5-fluorouracil encapsulation.

    abstract::This study proposed a new inorganic host for drug encapsulation. Porous clay heterostructure (PCH), synthesized using modified montmorillonite with hexadecyltrimethylammonium bromide, was used as host material and 5-fluorouracil (5-FU) as guest drug. Drug encapsulation within PCH in different conditions (soaking time,...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2015.05.053

    authors: Gârea SA,Mihai AI,Ghebaur A,Nistor C,Sârbu A

    更新日期:2015-08-01 00:00:00

  • Alcohol enhanced permeation in model membranes. Part II. Thermodynamic analysis of membrane partitioning.

    abstract::The role of solvents in drug transport has not been properly addressed in the literature, despite its well known influence on drug permeation. Previously we have conducted thermodynamic and kinetic analyses to probe the molecular mechanisms of alcohol enhanced permeation. In the present study, the influence of tempera...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2011.08.037

    authors: Oliveira G,Beezer AE,Hadgraft J,Lane ME

    更新日期:2011-11-28 00:00:00

  • Investigation of the parameters used in fused deposition modeling of poly(lactic acid) to optimize 3D printing sessions.

    abstract::This study assesses the feasibility of printing implantable devices using 3D printing Fused deposition modeling (FDM) technology. The influence of the deposition temperature, the deposition rate and the layer thickness on the printing process and the physical properties of the devices were evaluated. The filaments wer...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.05.008

    authors: Carlier E,Marquette S,Peerboom C,Denis L,Benali S,Raquez JM,Amighi K,Goole J

    更新日期:2019-06-30 00:00:00

  • A multifunctional ternary Cu(II)-carboxylate coordination polymeric nanocomplex for cancer thermochemotherapy.

    abstract::Metal-based photothermal therapy has been widely used in the biomedicine field and includes gold nanoparticles, silver nanoparticles and copper sulfide nanoparticles. Furthermore, the coordination bonding-based metal nanocomplex is a new generation of photothermal agents for cancer therapy due to its high photothermal...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2018.06.048

    authors: Zhang C,Li J,Qian C,Luo X,Wang K,Zhao P,Sun M

    更新日期:2018-10-05 00:00:00

  • Influence of surface charge and inner composition of porous nanoparticles to cross blood-brain barrier in vitro.

    abstract::The aim of these studies was to evaluate the binding, uptake and transcytosis of 60 nm porous nanoparticles (NPs) that differed in their surface charge and inner composition on the blood-brain barrier (BBB). They were prepared from maltodextrins derived with or without a cationic ligand. In the cationic NPs an anionic...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2007.06.023

    authors: Jallouli Y,Paillard A,Chang J,Sevin E,Betbeder D

    更新日期:2007-11-01 00:00:00

  • Penetration of topical and oral ofloxacin into the aqueous and vitreous humor of inflamed rabbit eyes.

    abstract:PURPOSE:This study aimed to investigate the penetration of topical and oral ofloxacin into aqueous humor and vitreous humor in post-traumatic endophthalmitis model in rabbits. METHODS:A standardized intraocular infection after penetrating injury was made in the right eyes of 16 rabbits. Intraocular infection was induc...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(00)00482-8

    authors: Oztürk F,Kurt E,Inan UU,Kortunay MC,Ilker SS,Başci NE,Bozkurt A

    更新日期:2000-08-25 00:00:00

  • Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo.

    abstract::Epidermal growth factor receptor (EGFR) is an important anti-cancer therapy target that is applicable to many cancer types. We had previously reported the screening and discovery of a novel peptide ligand against EGFR named GE11. It was shown to bind to EGFR competitively with EGF and mediate gene delivery to cancer c...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2008.07.012

    authors: Song S,Liu D,Peng J,Sun Y,Li Z,Gu JR,Xu Y

    更新日期:2008-11-03 00:00:00

  • Quantifying electrostatic interactions in pharmaceutical solid systems.

    abstract::Triboelectrification of pharmaceutical powders with stainless steel and polymer contact surfaces was investigated. alpha-Lactose monohydrate, from 90 to 125 up to 355-500 microm, was used to quantify electrostatic interactions with negligible powder adhesion to the contact surface. Size fractions down to 53-75 microm ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(01)00784-0

    authors: Rowley G

    更新日期:2001-10-04 00:00:00

  • Chitosan-magnesium aluminum silicate composite dispersions: characterization of rheology, flocculate size and zeta potential.

    abstract::Composite dispersions of chitosan (CS), a positively charged polymer, and magnesium aluminum silicate (MAS), a negatively charged clay, were prepared and rheology, flocculate size and zeta potential of the CS-MAS dispersions were investigated. High and low molecular weights of CS (HCS and LCS, respectively) were used ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2007.09.038

    authors: Khunawattanakul W,Puttipipatkhachorn S,Rades T,Pongjanyakul T

    更新日期:2008-03-03 00:00:00

  • Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing.

    abstract::In this study, a blend mixture of chitosan-ethylenediaminetetraacetic acid (CS 2 wt%-EDTA) at a weight ratio of 30/70 and polyvinyl alcohol (PVA) solution (10 wt%) was electrospun to produce fibrous mats with lysozyme (10, 20 and 30 wt%) used for wound healing. The morphology and diameter of the electrospun fiber mats...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.02.010

    authors: Charernsriwilaiwat N,Opanasopit P,Rojanarata T,Ngawhirunpat T

    更新日期:2012-05-10 00:00:00

  • Development and evaluation of PLA-coated co-micellar nanosystem of Resveratrol for the intra-articular treatment of arthritis.

    abstract::Arthritis is a chronic degenerative joint disease decreasing the patient's quality of life. Mixed micellar system (MM) was exploited as a nanotechnology platform suitable for the encapsulation of the water-insoluble drug, Resveratrol (RES). MM were prepared using different ratios of poloxamer 188 (P188) and poloxamer ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.118560

    authors: Kamel R,Abbas H,Shaffie NM

    更新日期:2019-10-05 00:00:00

  • The breakage behaviour of Aspirin under quasi-static indentation and single particle impact loading: effect of crystallographic anisotropy.

    abstract::The influence of crystallographic structural anisotropy on the breakage behaviour of Aspirin under impact loading is highlighted. Under both quasi-static testing conditions, using nano-indentation, and dynamic impact tests, Aspirin demonstrates clear anisotropy in its slip and fracture behaviour. During nano-indentati...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2011.03.039

    authors: Olusanmi D,Roberts KJ,Ghadiri M,Ding Y

    更新日期:2011-06-15 00:00:00

  • Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder for which the research of new treatments is highly challenging. Since the fibrillogenesis of amyloid-β peptide 1-42 (Aβ(1-42)) peptide is considered as a major cause of neuronal degeneration, specific interest has been focused on aromatic molecules for targeting...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2011.01.015

    authors: Le Droumaguet B,Souguir H,Brambilla D,Verpillot R,Nicolas J,Taverna M,Couvreur P,Andrieux K

    更新日期:2011-09-20 00:00:00