当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.

Lubrication properties of potential alternative lubricants, glycerin fatty acid esters, to magnesium stearate.

Abstract：

:To study the usefulness of glycerin fatty acid ester Poem TR-FB (TR-FB) and Poem TR-HB (TR-HB) as lubricants, pressure transmission ratio, ejection force, disintegration time, and tensile strength were measured at different concentrations and mixing times for granules and tablets. When each lubricant was mixed at 0.1-3.0%, the increase in the pressure transmission ratio that was equal to or greater than that of Mg-St as well as the reduction in the ejection force was observed at a low concentration in both TR-FB and TR-HB, proving that they have excellent lubrication performance. The granules that were lubricated with TR-FB and TR-HB at even low concentration of 0.4% showed a more stable and sufficiently lower ejection force than with Mg-St from the first tablet after the start of compression. When they were mixed for 5-60 min, while the mixture with Mg-St showed a low pressure transmission ratio of 82% and a high ejection force of 500 N in the first tablet even when the mixing time was 60 min, a high pressure transmission ratio and a low ejection force were observed in TR-FB and TR-HB from the first tablet after mixing for 5-60 min, and these were maintained thereafter. As for the disintegration time and the tensile strength, a prolonged disintegration time and a decreased tensile strength, which are disadvantages of Mg-St, were not observed in TR-FB and TR-HB. Based on these results, it was concluded that TR-FB and TR-HB are useful as alternative lubricants to Mg-St.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Uchimoto T,Iwao Y,Ikegami Y,Murata T,Sonobe T,Miyagishima A,Itai S

doi

10.1016/j.ijpharm.2009.11.001

subject

Has Abstract

pub_date

2010-02-15 00:00:00

pages

91-8

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(09)00780-7

journal_volume

386

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Air classifier technology (ACT) in dry powder inhalation. Part 2. The effect of lactose carrier surface properties on the drug-to-carrier interaction in adhesive mixtures for inhalation.

    abstract：:The effect of carrier surface properties on drug particle detachment from carrier crystals during inhalation with a special test inhaler with basic air classifier has been studied for mixtures containing 0.4% budesonide. Carrier crystals were retained in the classifier during inhalation and subsequently examined for t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00264-3

    authors： de Boer AH,Hagedoorn P,Gjaltema D,Goede J,Kussendrager KD,Frijlink HW

    更新日期：2003-07-24 00:00:00

  • Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure.

    abstract：:The two polyhydroxy surfactants polyglycerol 6-distearate (Plurol(®)Stearique WL1009 - (PS)) and caprylyl/capryl glucoside (Plantacare(®) 810 - (PL)) are a class of PEG-free stabilizers, made from renewable resources. They were investigated for stabilization of aqueous solid lipid nanoparticle (SLN) and nanostructured...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.12.036

    authors： Kovacevic A,Savic S,Vuleta G,Müller RH,Keck CM

    更新日期：2011-03-15 00:00:00

  • Diffusion and binding of 5-fluorouracil in non-ionic hydrogels with interpolymer complexation.

    abstract：:Hydrogen-bonded interpolymer complexes can be used for development of novel dosage forms. In this study, two types of crosslinked hydrogels, copolymer networks of N-vinyl pyrrolidone and acrylamide (PVP-co-PAM) and interpenetrating polymer networks (IPN) composed of crosslinked PVP-co-PAM and poly(vinyl alcohol) (PVA)...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.037

    authors： Zhou W,Lu P,Sun L,Ji C,Dong J

    更新日期：2012-07-15 00:00:00

  • Synthesis of a bi-functional dendrimer-based nanovehicle co-modified with RGDyC and TAT peptides for neovascular targeting and penetration.

    abstract：:The dual-ligand dendritic polyamidoamine-(polyethylene glycol)n-cyclic RGDyC peptide-(TAT peptide) (PPnR(T)) with various supplied molar ratios of polyethylene glycol (PEG) to polyamidoamine (PAMAM) (n=5, 15, 30) were designed as drug-carriers for the treatment of neovascular diseases; their targeting and penetrating ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.068

    authors： Li J,Zhang X,Wang M,Li X,Mu H,Wang A,Liu W,Li Y,Wu Z,Sun K

    更新日期：2016-03-30 00:00:00

  • Effects of different combinations of nanocrystallization technologies on avanafil nanoparticles: in vitro, in vivo and stability evaluation.

    abstract：:The study investigated the effects of different combined top-down and bottom-up nanocrystallization technologies on particle size and solid state of avanafil nanoparticles. Combined antisolvent precipitation-ultrasonication (sonoprecipitation) technique was adopted to prepare 18 formulas according to 32.21 factorial d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.12.012

    authors： Soliman KA,Ibrahim HK,Ghorab MM

    更新日期：2017-01-30 00:00:00

  • Delivery of drugs to intracellular organelles using drug delivery systems: Analysis of research trends and targeting efficiencies.

    abstract：:Targeting of drug delivery systems (DDSs) to specific intracellular organelles (i.e., subcellular targeting) has been investigated in numerous publications, but targeting efficiency of these systems is seldom reported. We searched scientific publications in the subcellular DDS targeting field and analyzed targeting ef...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2015.10.053

    authors： Maity AR,Stepensky D

    更新日期：2015-12-30 00:00:00

  • Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: a comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes.

    abstract：:Poly[lactic-co-glycolide] (PLGA) nanoparticles, chitosan-dextran sulphate microparticles, and DOTAP-liposomes were prepared as vaccine adjuvants and drug carriers for a small hydrophilic model peptide, and their different physico-chemical properties (size, PDI, zeta-potential, pH-value and peptide loading) were invest...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.09.011

    authors： Wieber A,Selzer T,Kreuter J

    更新日期：2011-12-12 00:00:00

  • Solubility of drugs in aqueous solutions. Part 3: multicomponent mixed solvent.

    abstract：:The results obtained previously by Ruckenstein and Shulgin [Int. J. Pharm. 258 (2003a) 193; Int. J. Pharm. 260 (2003b) 283] via the fluctuation theory of solutions regarding the solubility of drugs in binary aqueous mixed solvents were extended in the present paper to multicomponent aqueous solvents. The multicomponen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.08.006

    authors： Ruckenstein E,Shulgin I

    更新日期：2003-11-28 00:00:00

  • Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system.

    abstract：:In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cance...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.11.025

    authors： Yu F,Wu H,Tang Y,Xu Y,Qian X,Zhu W

    更新日期：2018-01-30 00:00:00

  • A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma.

    abstract：:A polymeric prodrug of cisplatin (CP) with simple chemical structure was synthesized based on pullulan and its therapeutic effects on human hepatocellular carcinoma (HCC) were studied in vitro and in vivo. Briefly, CP was linked to pullulan monosuccinate (SUPA) via coordination bond to form prodrug of CP-SUPA with the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.02.027

    authors： Wang Y,Liu Y,Liu Y,Zhou W,Wang H,Wan G,Sun D,Zhang N,Wang Y

    更新日期：2015-04-10 00:00:00

  • Development of low dose micro-tablets by high shear wet granulation process.

    abstract：:Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges associated with directly compressed low dose micro-tablets, in this study...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119571

    authors： Gupta S,Thool P,Meruva S,Li J,Patel J,Agrawal A,Karki S,Bowen W,Mitra B

    更新日期：2020-09-25 00:00:00

  • Impact of product design parameters on in vitro release from intrauterine systems.

    abstract：:Polydimethylsiloxane (PDMS)-based levonorgestrel intrauterine systems (LNG-IUSs) contain a large amount of potent LNG, and therefore it is important to understand the impact of product design parameters on the in vitro and in vivo performance to ensure safety and efficacy, as well as to avoid serious side effects resu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119135

    authors： Bao Q,Zou Y,Wang Y,Choi S,Burgess DJ

    更新日期：2020-03-30 00:00:00

  • Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations.

    abstract：:Transdermal delivery represents a very attractive administration route that provides various advantages over other methods of administration, including enhanced patient compliance via non-invasive, painless and simple application and reduced side effects. Thereby, the research on suitable drugs for this route continue...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118571

    authors： Shakel Z,Nunes C,Costa Lima SA,Reis S

    更新日期：2019-10-05 00:00:00

  • In-line monitoring of pellet coating thickness growth by means of visual imaging.

    abstract：:Coating thickness is the most important attribute of coated pharmaceutical pellets as it directly affects release profiles and stability of the drug. Quality control of the coating process of pharmaceutical pellets is thus of utmost importance for assuring the desired end product characteristics. A visual imaging tech...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.066

    authors： Oman Kadunc N,Sibanc R,Dreu R,Likar B,Tomaževič D

    更新日期：2014-08-15 00:00:00

  • Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride.

    abstract：:The feasibility of a colorimetric technique was investigated in CIELAB color space as an analytical quality control method for content uniformity of printed orodispersible pediatric delivery systems. Inkjet printing was utilized to fabricate orodispersibe film formulations containing propranolol hydrochloride in a col...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.032

    authors： Vakili H,Nyman JO,Genina N,Preis M,Sandler N

    更新日期：2016-09-10 00:00:00

  • A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells.

    abstract：:A novel method to include poorly water-soluble substances into the polyelectrolyte capsules of defined size, stability, composition and affinity properties is proposed. Encapsulation explores the polarity gradient across the capsule wall. Capsules creation makes use of electrostatic interaction and can involve many su...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00161-8

    authors： Radtchenko I,Sukhorukov G,Möhwald H

    更新日期：2002-08-21 00:00:00

  • Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.

    abstract：:Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis and activation, and although they display effectiveness in s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.006

    authors： Haggag YA,Matchett KB,Dakir el-H,Buchanan P,Osman MA,Elgizawy SA,El-Tanani M,Faheem AM,McCarron PA

    更新日期：2017-04-15 00:00:00

  • PAMAM dendrimers and model membranes: differential scanning calorimetry studies.

    abstract：:Dendrimers attract much attention as potential drug and gene carriers for intracellular delivery. From this point of view, it is crucial to extend our knowledge about their interactions with membranes. The influence of polyamidoamine (PAMAM) dendrimers on the thermotropic behavior of DPPC multilamellar vesicles and DM...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.08.015

    authors： Klajnert B,Epand RM

    更新日期：2005-11-23 00:00:00

  • Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance.

    abstract：:This study aims to investigate the effect of carrier characteristics and dosator capsule filling operation on the in vitro deposition of mixtures containing salbutamol sulphate (SS) and lactose and mannitol as model carrier materials. The carrier surfaces of lactose and mannitol were modified via wet decantation. The ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.06.044

    authors： Faulhammer E,Wahl V,Zellnitz S,Khinast JG,Paudel A

    更新日期：2015-08-01 00:00:00

  • Effect of varying the restriction degree of 4-aminopyridine release from HPMC matrices on the mechanism controlling the process.

    abstract：:Among different technological variables that influence drug release from hydrophilic matrices, different proportions of the polymer and a water-soluble excipient have been used to control the drug release properties. These variables were used to modify the drug release rate and to examine its effect on the mechanism c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00150-9

    authors： Martínez-González I,Villafuerte-Robles L

    更新日期：2003-05-12 00:00:00

  • Double barrier as an effective method for slower delivery rate of ibuprofen.

    abstract：:Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-lo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.06.037

    authors： Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

    更新日期：2014-09-10 00:00:00

  • Protease-functionalized mucus penetrating microparticles: In-vivo evidence for their potential.

    abstract：:The focus of the current study was to explore whether immobilization of proteases to microparticles could result in their enhanced penetration into mucus. The proteases papain (PAP) and bromelain (BROM) were covalently attached to a polyacrylate (PAA; Carbopol 971P) via amide bond formation based on carbodiimide react...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.08.114

    authors： Mahmood A,Laffleur F,Leonaviciute G,Bernkop-Schnürch A

    更新日期：2017-10-30 00:00:00

  • Inhalation treatment of idiopathic pulmonary fibrosis with curcumin large porous microparticles.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high mortality and poor prognosis. Curcumin shows anti-inflammatory effect by suppressing pro-inflammatory cytokines and inhibiting NF-κB mediated inflammation. Here, we developed inhalable curcumin-loaded poly(lactic-co-glycolic)acid ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.031

    authors： Hu Y,Li M,Zhang M,Jin Y

    更新日期：2018-11-15 00:00:00

  • Sericin grafted multifunctional curcumin loaded fluorinated graphene oxide nanomedicines with charge switching properties for effective cancer cell targeting.

    abstract：:Fluorinated graphene has recently gained much attention for cancer drug delivery, owing to its peculiar properties including high electronegativity difference, magnetic resonance imaging contrast agent, and the photothermal effect. However, the hydrophobic nature of fluorinated graphene greatly hinders its application...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118791

    authors： Jahanshahi M,Kowsari E,Haddadi-Asl V,Khoobi M,Lee JH,Kadumudi FB,Talebian S,Kamaly N,Mehrali M

    更新日期：2019-12-15 00:00:00

  • Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes.

    abstract：:The skin represents an attractive site for the localised gene therapy of dermatological pathologies and as a potential antigen bioreactor following transdermal delivery. Potential also exists for the gene therapy of skin as a cosmetic intervention. The most exploited non-viral gene delivery system involves the complex...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00336-7

    authors： Birchall JC,Marichal C,Campbell L,Alwan A,Hadgraft J,Gumbleton M

    更新日期：2000-03-20 00:00:00

  • The synergistic fungicidal effect of low-frequency and low-intensity ultrasound with amphotericin B-loaded nanoparticles on C. albicans in vitro.

    abstract：:It is difficult to effectively eradicate C. albicans using traditional antifungal agents, mainly because the low permeability of the C. albicans cell wall creates strong drug resistance. The aim of this study was to investigate the synergistic fungicidal effect and the underlying mechanisms of low-frequency and low-in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.033

    authors： Yang M,Xie S,Adhikari VP,Dong Y,Du Y,Li D

    更新日期：2018-05-05 00:00:00

  • Improving matrix metalloproteinase-2 specific response of a hydrogel system using electrophoresis.

    abstract：:Matrix metalloproteinases (MMPs) overexpression plays a critical role in cancer invasion and metastasis. We utilized this key feature of tumor microenvironment to develop a disease-stimuli triggered drug delivery system. Poly(acrylic acid) hydrogels were synthesized by UV polymerization and pendant MMP-2 sensitive pep...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.012

    authors： Zhang Y,Gemeinhart RA

    更新日期：2012-06-15 00:00:00

  • Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations.

    abstract：:We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can increase drug loading up to 95% while maintaining good aerosol performance. Drug loading affected the specific surface area and moisture sorption o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119490

    authors： Sahakijpijarn S,Moon C,Ma X,Su Y,Koleng JJ,Dolocan A,Williams RO 3rd

    更新日期：2020-08-30 00:00:00

  • Controllable encapsulation of α-mangostin with quaternized β-cyclodextrin grafted chitosan using high shear mixing.

    abstract：:In this study, the inclusion complex formation between α-mangostin and water-soluble quaternized β-CD grafted-chitosan (QCD-g-CS) was investigated. Inclusion complex formation with encapsulation efficiency (%EE) of 5, 15 and 75% can be varied using high speed homogenizer. Tuning %EE plays a role on physicochemical and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.12.016

    authors： Phunpee S,Suktham K,Surassmo S,Jarussophon S,Rungnim C,Soottitantawat A,Puttipipatkhachorn S,Ruktanonchai UR

    更新日期：2018-03-01 00:00:00

  • Preparation of enteric coated timed-release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting.

    abstract：:As a new oral drug delivery system for colon targeting, enteric coated timed-release press-coated tablets (ETP tablets) were developed by coating enteric polymer on timed-release press-coated tablets composed of an outer shell of hydroxypropylcellulose and core tablet containing diltiazem hydrochloride (DIL) as a mode...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00454-3

    authors： Fukui E,Miyamura N,Uemura K,Kobayashi M

    更新日期：2000-08-25 00:00:00