Abstract:
:Targeting of drug delivery systems (DDSs) to specific intracellular organelles (i.e., subcellular targeting) has been investigated in numerous publications, but targeting efficiency of these systems is seldom reported. We searched scientific publications in the subcellular DDS targeting field and analyzed targeting efficiency and major formulation parameters that affect it. We identified 77 scientific publications that matched the search criteria. In the majority of these studies nanoparticle-based DDSs were applied, while liposomes, quantum dots and conjugates were used less frequently. The nucleus was the most common intracellular target, followed by mitochondrion, endoplasmic reticulum and Golgi apparatus. In 65% of the publications, DDSs surface was decorated with specific targeting residues, but the efficiency of this surface decoration was not analyzed in predominant majority of the studies. Moreover, only 23% of the analyzed publications contained quantitative data on DDSs subcellular targeting efficiency, while the majority of publications reported qualitative results only. From the analysis of publications in the subcellular targeting field, it appears that insufficient efforts are devoted to quantitative analysis of the major formulation parameters and of the DDSs' intracellular fate. Based on these findings, we provide recommendations for future studies in the field of organelle-specific drug delivery and targeting.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Maity AR,Stepensky Ddoi
10.1016/j.ijpharm.2015.10.053subject
Has Abstractpub_date
2015-12-30 00:00:00pages
268-74issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30321-5journal_volume
496pub_type
杂志文章,评审abstract::Insulin replacement therapy is integral to the management of type 1 diabetes, which is characterised by absolute insulin deficiency. Optimal glycaemic control, as assessed by glycated haemoglobin, and avoidance of hyper- and hypoglycaemic excursions have been shown to prevent diabetes-related complications. Insulin pu...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章,评审
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abstract::Hydrotalcite (HT), also known as a layered double hydroxide (LDH) compound, has been widely used in past years in the formulation of drugs due to its specific properties including good biocompatibility, null toxicity, high chemical stability and pH-dependent solubility which aid in drug controlled release. In this wor...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2016.04.048
更新日期:2016-06-15 00:00:00
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journal_title:International journal of pharmaceutics
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更新日期:2016-07-25 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2017-06-15 00:00:00
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2016.05.049
更新日期:2016-07-25 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2001-08-28 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-04-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2018.07.069
更新日期:2018-10-05 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2012.04.075
更新日期:2012-08-20 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2017.11.025
更新日期:2018-01-30 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2013.06.010
更新日期:2013-09-10 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2015.05.059
更新日期:2015-07-25 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2009.09.010
更新日期:2010-01-04 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2005-01-31 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2007.09.038
更新日期:2008-03-03 00:00:00
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更新日期:2019-12-15 00:00:00
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更新日期:2016-06-15 00:00:00
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journal_title:International journal of pharmaceutics
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更新日期:2015-07-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2006-11-15 00:00:00
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journal_title:International journal of pharmaceutics
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更新日期:2015-11-10 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2018.11.041
更新日期:2019-01-30 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2016.12.048
更新日期:2017-02-25 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2006.02.008
更新日期:2006-06-06 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章,评审
doi:10.1016/j.ijpharm.2009.03.003
更新日期:2009-11-03 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2017.08.107
更新日期:2017-10-30 00:00:00
abstract::In the 1990s chitosan turned out to be a useful excipient in various pharmaceutical formulations. By modifications of the primary amino group at the 2-position of this poly(beta1-->4 D-glucosamine), the features of chitosan can even be optimised according to a given task in drug delivery systems. For peroral peptide d...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章,评审
doi:10.1016/s0378-5173(99)00365-8
更新日期:2000-01-20 00:00:00