A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells.

Abstract:

:A novel method to include poorly water-soluble substances into the polyelectrolyte capsules of defined size, stability, composition and affinity properties is proposed. Encapsulation explores the polarity gradient across the capsule wall. Capsules creation makes use of electrostatic interaction and can involve many substances as layer constituents, such as synthetic polyelectrolytes, proteins, nucleic acids, lipids and multivalent dyes. Using capsules made of synthetic polyelectrolytes as a model system was demonstrated how to prepare, to measure and to use this gradient for low molecular weigh materials encapsulation.

journal_name

Int J Pharm

authors

Radtchenko I,Sukhorukov G,Möhwald H

doi

10.1016/s0378-5173(02)00161-8

keywords:

subject

Has Abstract

pub_date

2002-08-21 00:00:00

pages

219-23

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378517302001618

journal_volume

242

pub_type

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