Abstract：
:Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be used for a variety of purposes, from classification (and sorting) of products to mapping spatial distribution of materials. The present study examined if NIR-CI is suitable for tablet manufacturing. To that end, the tablets were introduced into the CI system via a flat belt conveyor. A formulation, which consisted of 4wt.%-6wt.% caffeine, 5wt.% crospovidone as a disintegrant, 88wt.%-90wt.% lactose as a filler and 1wt.% magnesium stearate as a lubricator, was tableted at compression forces ranging from 5kN to 30kN. The intra- and inter-tablet homogeneity of caffeine and the tablet's hardness were analyzed via NIR-CI. For the homogeneity evaluation, two methods were applied: standard deviation (SD) and distributional homogeneity index (DHI). The results showed that the SD of caffeine in a single tablet increased with an increase in the caffeine content. This was attributed to natural variations in a binary mixture of caffeine and excipients. Overall, the chosen NIR-CI setup has strong potential to be transferred to the production scale to monitor all tablets in a production stream.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Wahl PR,Pucher I,Scheibelhofer O,Kerschhaggl M,Sacher S,Khinast JGdoi
10.1016/j.ijpharm.2016.12.003subject
Has Abstractpub_date
2017-02-25 00:00:00pages
130-137issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(16)31134-6journal_volume
518pub_type
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