当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

Abstract：

:TXA497 is representative of a new class of guanidinomethyl biaryl compounds that exhibit potent bactericidal behavior against methicillin-resistant Staphylococcus aureus (MRSA). In this study, we compared the anti-staphylococcal, skin deposition, and skin permeation properties of TXA497 and the topical anti-MRSA antibiotic mupirocin. The results of minimum inhibitory concentration (MIC) assays revealed that TXA497 retains potent activity against MRSA that is highly resistant to mupirocin. Using Franz diffusion cells, compound deposition into human cadaver skin was evaluated, and the results showed the skin deposition of TXA497 to be significantly greater than that of mupirocin. Moreover, unlike mupirocin, TXA497 does not pass through the entire skin layer, suggesting a minimal potential for the systemic absorption of the compound upon topical administration. Additionally, antibacterial concentrations of TXA497 showed no significant toxicity to primary human keratinocytes. Given the rising levels of mupirocin resistance among MRSA populations, our results are significant in that they highlight TXA497 as a potentially useful alternative therapy for treating MRSA skin infections that are resistant to mupirocin.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Dorrani M,Kaul M,Parhi A,LaVoie EJ,Pilch DS,Michniak-Kohn B

doi

10.1016/j.ijpharm.2014.09.033

subject

Has Abstract

pub_date

2014-12-10 00:00:00

pages

199-204

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(14)00688-7

journal_volume

476

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Optimization of a novel wax matrix system using aminoalkyl methacrylate copolymer E and ethylcellulose to suppress the bitter taste of acetaminophen.

    abstract：:The purpose of the present study was to design and evaluate a novel wax matrix system containing various ratios of aminoalkyl methacrylate copolymer E (AMCE) and ethylcellulose (EC) as functional polymers in order to achieve the optimal acetaminophen (APAP) release rate for taste masking. A two factor, three level (3(...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.05.007

    authors： Shiino K,Iwao Y,Miyagishima A,Itai S

    更新日期：2010-08-16 00:00:00

  • Comparative study of Pluronic(®) F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats.

    abstract：:Liposomes modified using cationic and hydrophilic nonionic polymers are 2 popular carriers for improving oral drug absorption. Cationic polymer-modified liposomes can adhere to the intestinal wall mucus (mucoadhesive type), while liposomes modified using hydrophilic nonionic polymers can penetrate across the mucus bar...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.04.002

    authors： Chen D,Xia D,Li X,Zhu Q,Yu H,Zhu C,Gan Y

    更新日期：2013-06-05 00:00:00

  • Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications.

    abstract：:In this study, a novel injectable hydrogel based on iota and kappa carrageenan, locust bean gum and gelatin was prepared for wound healing and tissue repairing applications. This injectable hydrogel was obtained via physical crosslinking. FTIR analysis confirmed the physical interaction between the biopolymeric compon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119828

    authors： Pettinelli N,Rodríguez-Llamazares S,Bouza R,Barral L,Feijoo-Bandín S,Lago F

    更新日期：2020-08-29 00:00:00

  • Cancer cell targeting and imaging with biopolymer-based nanodevices.

    abstract：:We report here the synthesis, in vitro and in vivo investigation of magnetic resonance imaging (MRI) active nanoparticles, which target folate receptor overexpressing tumor cells. Self-assembled nanoparticles with a hydrodynamic size of 50-200 nm were prepared from poly-γ-glutamic acid and chitosan biopolymers with Gd...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.11.038

    authors： Hajdu I,Bodnár M,Trencsényi G,Márián T,Vámosi G,Kollár J,Borbély J

    更新日期：2013-01-30 00:00:00

  • Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems.

    abstract：:The presence of large amounts of reactive oxygen species (ROS) leads to oxidative stress that can damage cell membranes, lead to DNA breakage and cause inactivation of free radical scavenger enzymes, eventually resulting in skin damage. Quercetin is a natural flavonoid that has been shown to have the highest anti-radi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.12.013

    authors： Bose S,Du Y,Takhistov P,Michniak-Kohn B

    更新日期：2013-01-30 00:00:00

  • Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics.

    abstract：:Clinical performance of an amorphous solid dispersion (ASD) drug product is related to the amorphous drug content because of the greater bioavailability of this form of the drug than its crystalline form. Therefore, it is paramount to monitor the amorphous and the crystalline fractions in the ASD products. The objecti...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.050

    authors： Rahman Z,Siddiqui A,Bykadi S,Khan MA

    更新日期：2014-11-20 00:00:00

  • Understanding the structure and stability of paclitaxel nanocrystals.

    abstract：:Previously, PTX/Pluronic F127 nanocrystals were prepared in our laboratory using the stabilization of nanocrystals (SNC) method. For PTX nanocrystals, dosages could be increased to yield improved antitumor activity over Taxol without incidence of acute toxicity. The objectives of this current study are to further unde...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.02.013

    authors： Deng J,Huang L,Liu F

    更新日期：2010-05-10 00:00:00

  • On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships.

    abstract：:Recent studies demonstrated that post-herpetical and inflammatory pain can be locally managed by morphine gels, empirically chosen. Aiming to rationalize the selection of the most suitable opioid for the cutaneous delivery, we studied the in vitro penetration through human epidermis of eight opioids, evidencing the cr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.04.071

    authors： Musazzi UM,Matera C,Dallanoce C,Vacondio F,De Amici M,Vistoli G,Cilurzo F,Minghetti P

    更新日期：2015-07-15 00:00:00

  • Saturation solubility of nicotine, scopolamine and paracetamol in model stratum corneum lipid matrices.

    abstract：:The saturation solubilities of nicotine and scopolamine bases as well as acidic paracetamol were measured in two different model stratum corneum lipid matrices. Light microscopy visualized the presence of drug above its solubility either as droplets or crystalline particles. Neither wide-angle X-ray diffraction nor DS...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.06.057

    authors： Mundstock A,Lee G

    更新日期：2014-10-01 00:00:00

  • Effect of the combination of organic and inorganic filters on the Sun Protection Factor (SPF) determined by in vitro method.

    abstract：:This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tes...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.05.047

    authors： El-Boury S,Couteau C,Boulande L,Paparis E,Coiffard LJ

    更新日期：2007-08-01 00:00:00

  • Nanosuspension for improving the bioavailability of a poorly soluble drug and screening of stabilizing agents to inhibit crystal growth.

    abstract：:The purpose of this study was to develop a nanosuspension of a poorly soluble drug by nanomilling process using wet media milling to achieve superior in vitro dissolution and high in vivo exposure in pharmacokinetic studies. A promising nanosuspension was developed with Vitamin E TPGS based formulation with particle s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.051

    authors： Ghosh I,Bose S,Vippagunta R,Harmon F

    更新日期：2011-05-16 00:00:00

  • Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation.

    abstract：:To enhance the stability of the anticancer drug gemcitabine (2'-deoxy-2',2'-difluorocytidine), it was conjugated to poly-l-glutamic acid (PG-H) via a carbodiimide reaction. The synthesised poly-l-glutamic acid-gemcitabine (PG-G) was purified and characterised by using SDS-PAGE to estimate its molecular weight, HPLC to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.03.010

    authors： Kiew LV,Cheong SK,Sidik K,Chung LY

    更新日期：2010-05-31 00:00:00

  • Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.

    abstract：:The purpose of this study was to construct microemulsion-base hydrogel formulation for topical delivery of ibuprofen. Ethyl oleate (EO) was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulison systems and excellent skin permeation rate of ibuprofen. The pseudo-ternary p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.015

    authors： Chen H,Chang X,Du D,Li J,Xu H,Yang X

    更新日期：2006-06-06 00:00:00

  • Quantitation of trace amorphous solifenacin succinate in pharmaceutical formulations by transmission Raman spectroscopy.

    abstract：:It is important to quantify amorphous solid in active pharmaceutical ingredients (API) of formulations to guarantee high-quality pharmaceutical products. In this study, we aimed to quantify amorphous solid in API by transmission Raman spectroscopy (TRS) and transmission near-infra-red spectroscopy (NIRS). To quantify ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.05.017

    authors： Terada H,Hattori Y,Sasaki T,Otsuka M

    更新日期：2019-06-30 00:00:00

  • The effects of serum on the stability and the transfection activity of the cationic lipid emulsion with various oils.

    abstract：:The emulsions with various oils such as linseed oil, soybean oil and squalene were prepared to obtain the relationship between the stability and the transfection activity of the emulsions. 1,2-Dioleoyl-sn-glycero-3-trimethylammonium-propane (DOTAP) was used as a single cationic lipid emulsifier. The droplet sizes and ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00676-2

    authors： Kim YJ,Kim TW,Chung H,Kwon IC,Sung HC,Jeong SY

    更新日期：2003-02-18 00:00:00

  • Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model.

    abstract：:Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the perf...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.04.023

    authors： Frant M,Dayyoub E,Bakowsky U,Liefeith K

    更新日期：2018-07-30 00:00:00

  • Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously.

    abstract：:Drug solubility and lymphatic transport enhancements are two main pathways to improve drug oral bioavailability for microemulsions. However, it is not easy to have both achieved simultaneously because excipients used for improving lymphatic transport were usually insufficient in forming microemulsions and solubilizing...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.061

    authors： Xing Q,Song J,You X,Xu D,Wang K,Song J,Guo Q,Li P,Wu C,Hu H

    更新日期：2016-09-25 00:00:00

  • Compression of pellets coated with various aqueous polymer dispersions.

    abstract：:Pellets coated with a new aqueous polyvinyl acetate dispersion, Kollicoat SR 30 D, could be compressed into tablets without rupture of the coating providing unchanged release profiles. In contrast, the compression of pellets coated with the ethylcellulose dispersion, Aquacoat ECD 30, resulted in rupture of the coating...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.03.019

    authors： Dashevsky A,Kolter K,Bodmeier R

    更新日期：2004-07-26 00:00:00

  • Influence of membrane structure on the preparation of colloidal lipid dispersions by premix membrane emulsification.

    abstract：:Since premix membrane emulsification was developed as alternative technique for the preparation of emulsions and solid lipid particles as carrier systems for lipophilic drugs, many types of membranes have been used in this preparation process. The purpose of this study was to evaluate the influence of different types ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.02.013

    authors： Joseph S,Bunjes H

    更新日期：2013-03-25 00:00:00

  • A novel approach to avoid capping and/or lamination by application of external lower punch vibration.

    abstract：:Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes such as the coating. In this context, there is an urgent need for approaches to ov...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119195

    authors： Kalies A,Heinrich T,Leopold CS

    更新日期：2020-04-30 00:00:00

  • Advances and challenges in nanocarriers and nanomedicines for veterinary application.

    abstract：:To ensure success in the development and manufacturing of nanomedicines requires forces of an interdisciplinary team that combines medicine, engineering, chemistry, biology, material and pharmaceutical areas. Numerous researches in nanotechnology applied to human health are available in the literature. Althought, the ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2020.119214

    authors： Carvalho SG,Araujo VHS,Dos Santos AM,Duarte JL,Silvestre ALP,Fonseca-Santos B,Villanova JCO,Gremião MPD,Chorilli M

    更新日期：2020-04-30 00:00:00

  • Application of a chromatic confocal measurement system as new approach for in-line wet film thickness determination in continuous oral film manufacturing processes.

    abstract：:The key parameter of the oral film production process is the wet film thickness since it regulates the active pharmaceutical ingredient (API) content of the finished product. There is no general recommendation on how to adjust the gap height of the coating knife during the film manufacturing process to obtain the targ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.028

    authors： Niese S,Quodbach J

    更新日期：2018-11-15 00:00:00

  • The effects of esterified solvents on the diffusion of a model compound across human skin: an ATR-FTIR spectroscopic study.

    abstract：:Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to investigate the effects of three fatty acid esters on skin permeation. Propylene glycol diperlargonate (DPPG), isopropyl myristate (IPM) and isostearyl isostearate (ISIS) were selected as pharmaceutically relevant solvents...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.02.022

    authors： McAuley WJ,Chavda-Sitaram S,Mader KT,Tetteh J,Lane ME,Hadgraft J

    更新日期：2013-04-15 00:00:00

  • Fluid bed agglomeration with a narrow droplet size distribution.

    abstract：:In the fluid bed agglomeration processes liquid distribution influences the agglomerate growth. We developed a new nozzle that produces uniform droplets, which allows droplets to be easily controlled in size independently of liquid- and airflow of the nozzle. It was found that the spray rate and the mixing in the spra...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00329-4

    authors： Schaafsma SH,Vonk P,Kossen NW

    更新日期：2000-01-05 00:00:00

  • Retention and distribution of two 99mTc-DTPA labelled vaginal dosage forms.

    abstract：UNLABELLED:To objectively evaluate the performance of new vaginal dosage forms, it is important to determine their time of residence and their distribution. This paper describes the in vivo characteristics of a reference and test product in this situation. METHOD:A randomised cross-over study was performed in the same...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2003.11.006

    authors： Chatterton BE,Penglis S,Kovacs JC,Presnell B,Hunt B

    更新日期：2004-03-01 00:00:00

  • Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example.

    abstract：:The aim of this study was to develop a sensitive and discriminative in vitro-in silico model able to simulate the in vivo performance of three fenofibrate immediate release formulations containing different surfactants. In addition, the study was designed to investigate the effect of dissolution volume when predicting...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijpharm.2014.06.060

    authors： Berthelsen R,Sjögren E,Jacobsen J,Kristensen J,Holm R,Abrahamsson B,Müllertz A

    更新日期：2014-10-01 00:00:00

  • Inhalable co-amorphous budesonide-arginine dry powders prepared by spray drying.

    abstract：:Spray drying is a well-established technology to produce inhalable dry powders. However, the amorphous nature of the particles typically obtained from the process can lead to physically and chemically unstable products. The purpose of this study was to investigate whether spray-drying could be used as a manufacturing ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.04.036

    authors： Lu W,Rades T,Rantanen J,Yang M

    更新日期：2019-06-30 00:00:00

  • Induction of apoptosis of human lung carcinoma cells by hybrid liposomes containing polyoxyethylenedodecyl ether.

    abstract：:Hybrid liposomes can be prepared by simply ultrasonicating a mixture of vesicular and micellar molecules in aqueous solution. A clear solution of hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(23)dodecyl ether (C12(EO)23) having a hydrodynamic diameter of 100-120...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.034

    authors： Iwamoto Y,Matsumoto Y,Ueoka R

    更新日期：2005-03-23 00:00:00

  • Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration.

    abstract：:Lipid nanoparticles (LNs) are widely investigated for oral drug delivery, and for achieving significant advantages in colloidal stability, biocompatibility and scaled-up possibility. However, researchers face challenge of developing methods to improve the ability of LNs in overcoming multiple barriers (i.e., mucus and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.015

    authors： Wu L,Liu M,Shan W,Cui Y,Zhang Z,Huang Y

    更新日期：2017-03-30 00:00:00

  • Poly(acrylic acid) microspheres containing beta-cyclodextrin: loading and in vitro release of two dyes.

    abstract：:Microspheres containing poly(acrylic acid) and beta-cyclodextrin or maltose were prepared by a w/o solvent evaporation technique. The dispersed aqueous phase contained poly(acrylic acid) (800 mg) and beta-cyclodextrin or maltose (0, 200 or 800 mg). Food-grade olive oil was the continuous phase. Microsphere particle si...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00190-8

    authors： Bibby DC,Davies NM,Tucker IG

    更新日期：1999-10-05 00:00:00