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Nanosuspension for improving the bioavailability of a poorly soluble drug and screening of stabilizing agents to inhibit crystal growth.

Abstract：

:The purpose of this study was to develop a nanosuspension of a poorly soluble drug by nanomilling process using wet media milling to achieve superior in vitro dissolution and high in vivo exposure in pharmacokinetic studies. A promising nanosuspension was developed with Vitamin E TPGS based formulation with particle size in the nano range. Although the formulation showed significant improvement during in vitro dissolution and in vivo plasma level, probably due to the strong hydrophobic interaction between Vitamin TPGS and the drug molecule, crystal growth was observed during stability studies. A systematic study was done with different combinations of solubilizer/stabilizer system in order to obtain a more stable nanosuspension. Hydroxypropyl methylcellulose (HPMC 3 cps) was found to stabilize the nanosuspension by better surface coverage due to stronger interaction with the drug as compared to other stabilizers used in this study.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ghosh I,Bose S,Vippagunta R,Harmon F

doi

10.1016/j.ijpharm.2011.02.051

subject

Has Abstract

pub_date

2011-05-16 00:00:00

pages

260-8

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)00186-4

journal_volume

409

pub_type

杂志文章

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