Abstract：
:Microspheres containing poly(acrylic acid) and beta-cyclodextrin or maltose were prepared by a w/o solvent evaporation technique. The dispersed aqueous phase contained poly(acrylic acid) (800 mg) and beta-cyclodextrin or maltose (0, 200 or 800 mg). Food-grade olive oil was the continuous phase. Microsphere particle size was consistently between 15 and 25 microm, and carbohydrate content was in good agreement with that added to the dispersed phase in all cases. Two dyes, phenolphthalein and rhodamine B, having different solubility characteristics and strengths of association with beta-cyclodextrin, were selected for loading and in vitro release studies. Microspheres were loaded by soaking in a saturated propan-2-ol solution of the appropriate dye (6 h). Microsphere dye content ranged between 2.8 and 4.8 mg/g microspheres for phenolphthalein and between 2.2 and 3.7 mg/g for rhodamine B. Release studies were performed in phosphate buffer (pH 7.4; 37 degrees C). No difference in the release profile of either dye was observed between microspheres. The failure of microspheres containing beta-cyclodextrin in particular, to alter the in vitro release kinetics of either dye may be due to a number of factors and include: (i) limited cross-linking giving rise to a the rapid hydration of the polymer matrix; (ii) perturbation of the dye-beta-cyclodextrin complex by oil and/or organic solvent residues; and (iii) conformational changes/steric hindrance of the beta-cyclodextrin cavity (due to its covalent binding with PAA) resulting in a reduction in its ability to form inclusion complexes.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Bibby DC,Davies NM,Tucker IGdoi
10.1016/s0378-5173(99)00190-8keywords:
subject
Has Abstractpub_date
1999-10-05 00:00:00pages
243-50issue
2eissn
0378-5173issn
1873-3476pii
S0378517399001908journal_volume
187pub_type
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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abstract：:Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes such as the coating. In this context, there is an urgent need for approaches to ov...
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更新日期：2015-11-10 00:00:00
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更新日期：2014-09-10 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2006-07-06 00:00:00
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更新日期：2018-12-01 00:00:00
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更新日期：2015-10-15 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2003-11-06 00:00:00
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journal_title：International journal of pharmaceutics
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doi：10.1016/j.ijpharm.2015.09.008
更新日期：2015-11-10 00:00:00
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更新日期：2001-06-04 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2009-01-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-06-05 00:00:00
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pub_type： 杂志文章
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更新日期：2005-03-23 00:00:00
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pub_type： 杂志文章
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更新日期：2018-07-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-05-22 00:00:00
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更新日期：2017-11-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2019-03-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2005.07.028
更新日期：2006-05-18 00:00:00
abstract：:The present study demonstrated the prediction of predominant root causes of capping behavior as a function of the powder rheological and the mechanical behavior of Acetaminophen (APAP) and Ibuprofen (IBU). The authors analyzed powder rheological properties for powder blend permeability, pressure drop, and cohesion. Th...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2019.118548
更新日期：2019-10-05 00:00:00
