当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Development and evaluation of PLA-coated co-micellar nanosystem of Resveratrol for the intra-articular treatment of arthritis.

Development and evaluation of PLA-coated co-micellar nanosystem of Resveratrol for the intra-articular treatment of arthritis.

Abstract：

:Arthritis is a chronic degenerative joint disease decreasing the patient's quality of life. Mixed micellar system (MM) was exploited as a nanotechnology platform suitable for the encapsulation of the water-insoluble drug, Resveratrol (RES). MM were prepared using different ratios of poloxamer 188 (P188) and poloxamer 407 (P407), and then subjected to in-vitro evaluation. The selected MM (MM3) composed of P188: P407 in a ratio of 2:1 attained the most compromised properties (Particle size = 52.97 ± 4.52 nm, Encapsulation Efficiency = 76.20 ± 4.51 and Release efficiency = 76.26 ± 6.25), and was coated with poly-lactic acid (PLA). TEM photographs of PLA-coated MM3 showed a polymeric layer surrounding the nanoparticles. Rats with induced arthritis were used to study the curative effect of intra-articularly (IA)-injected MM3, PLA-coated MM3 as well as the drug suspension. All the treated groups showed a significant therapeutic improvement in arthritis proved by measuring rats knee diameter as well as the tumor necrosis factor-alpha (TNF-α). The treatment effectiveness was in the following order: PLA-coated MM3 ˃ MM3 ˃ drug suspension, (p < 0.05). Histological study showed the recovery of the joints and synovial structure by IA administration of the drug-loaded micellar nanosystems, and the PLA-coated MM attained the best effect. This study proves the promising curative effect of the designed nanotechnology-based drug carrier.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Kamel R,Abbas H,Shaffie NM

doi

10.1016/j.ijpharm.2019.118560

subject

Has Abstract

pub_date

2019-10-05 00:00:00

pages

118560

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(19)30604-0

journal_volume

569

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Dynamic behavior of a spring-powered micronozzle needle-free injector.

    abstract：:Conventional injection is still the leading method to deliver macromolecular therapeutics. Needle injection is considered a low compliance administration strategy, principally due to pain and needle phobia. This has fostered the research on the development of alternative strategies to circumvent the skin barrier. Amon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.067

    authors： Schoubben A,Cavicchi A,Barberini L,Faraon A,Berti M,Ricci M,Blasi P,Postrioti L

    更新日期：2015-08-01 00:00:00

  • In vitro and in vivo degradation behavior and the long-term performance of biodegradable PLCL balloon implants.

    abstract：:Biodegradable poly(l-lactide-co-ε-caprolactone) (PLCL) are used to prepare inflatable balloon implants in treating rotator-cuff injuries and tissue separation. These balloon implants act as a temporary spacer for tissues, while reducing pain and allowing rehabilitation after surgery. It is essential to ensure that eac...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118870

    authors： Haim Zada M,Kumar A,Elmalak O,Markovitz E,Icekson R,Domb AJ

    更新日期：2020-01-25 00:00:00

  • A prototype 'Infucon' device for continuous infusion of microbubbles in vivo.

    abstract：:A device for continuous infusion of microbubbles (MBs) 'Infucon' has been designed, constructed and tested on rabbits. The device prevents MBs from flotation and accumulation in the layer directly below the surface in the syringe injection during i.v. application. Homogenous i.v. application of MBs was tested on 16 ma...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.12.026

    authors： Kauerová Z,Lukáč R,Kohout P,Mašek J,Koudelka Š,Plocková J,Vašíčková M,Vlašín M,Turánek J

    更新日期：2013-01-30 00:00:00

  • Mucoadhesive zein/beta-cyclodextrin nanoparticles for the buccal delivery of curcumin.

    abstract：:Herein, we have developed sprayable dispersions of mucoadhesive nanoparticles (NPs) made of zein, a hydrophobic plant-based protein, for the buccal delivery of curcumin (CUR), a poorly water-soluble polyphenol. NPs were prepared by the liquid-liquid dispersion method using an antisolvent water solution without or with...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119587

    authors： Esposito D,Conte C,d'Angelo I,Miro A,Ungaro F,Quaglia F

    更新日期：2020-08-30 00:00:00

  • Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers.

    abstract：:In this study, the potential of lecithin/chitosan nanoparticles (NPs) as a mucoadhesive colloidal nanosystem for transmucosal delivery of melatonin was investigated. The size, zeta potential and melatonin loading of the lecithin/chitosan NPs were investigated as a function of lecithin type (Lipoid S45, S75 and S100) a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.07.001

    authors： Hafner A,Lovrić J,Voinovich D,Filipović-Grcić J

    更新日期：2009-11-03 00:00:00

  • Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model validation.

    abstract：:Although the extraordinary solubility advantage afforded by cyclodextrins has led to their widespread use as pharmaceutical solubilizers, several reports have emerged that cyclodextrins may also reduce the apparent permeability of the drug. With the purpose to investigate this solubility-permeability interplay, we hav...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.017

    authors： Miller JM,Dahan A

    更新日期：2012-07-01 00:00:00

  • Permeability of surface-modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers.

    abstract：:Aim of this study was to prepare polyamine-conjugated PAMAM dendrimers and study their permeability across Caco-2 cell monolayers. Polyamines, namely, arginine and ornithine were conjugated to the amine terminals of the G4 PAMAM dendrimers by Fmoc synthesis. The apical-to-basolateral (AB) and basolateral-to-apical (BA...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.08.033

    authors： Pisal DS,Yellepeddi VK,Kumar A,Kaushik RS,Hildreth MB,Guan X,Palakurthi S

    更新日期：2008-02-28 00:00:00

  • Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms.

    abstract：:Directly compressed matrices were produced containing either xanthan gum or karaya gum as a release-controlling agent. These swellable hydrophilic natural gums were used to control the release of varying proportions of two model drugs, caffeine and diclofenac sodium, which have different solubilities in aqueous medium...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00444-0

    authors： Munday DL,Cox PJ

    更新日期：2000-08-10 00:00:00

  • Intranasal spray formulation containing rizatriptan benzoate for the treatment of migraine.

    abstract：:Rizatriptan produces antimigraine activity by acting as selective agonist of 5-HT1B and 5-HT1D receptors present on intracranial and extracerebral blood vessels. Absorption from oral tablet is slow with Tmax of approximately 1-1.5 h. A few attempts have been made to promote rapid absorption such as oral or sublingual ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118702

    authors： Chokshi A,Vaishya R,Inavolu R,Potta T

    更新日期：2019-11-25 00:00:00

  • The use of high-speed differential scanning calorimetry (Hyper-DSC) in the study of pharmaceutical polymorphs.

    abstract：:The thermal properties of two polymorphs (A and C) of a Merck development compound were studied using high-speed differential scanning calorimetry (Hyper-DSC). The utility of this novel technique as a fast analytical tool for studying the polymorphic behaviour of metastable polymorphs has previously been demonstrated ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.08.015

    authors： McGregor C,Bines E

    更新日期：2008-02-28 00:00:00

  • Application of a chromatic confocal measurement system as new approach for in-line wet film thickness determination in continuous oral film manufacturing processes.

    abstract：:The key parameter of the oral film production process is the wet film thickness since it regulates the active pharmaceutical ingredient (API) content of the finished product. There is no general recommendation on how to adjust the gap height of the coating knife during the film manufacturing process to obtain the targ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.028

    authors： Niese S,Quodbach J

    更新日期：2018-11-15 00:00:00

  • Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery.

    abstract：:pH-responsive polymer shell chitosan/poly (methacrylic acid) (CS-PMAA) was coated on mesoporous silica nanoparticles (MSN) through the facile in situ polymerization method. The resultant composite microspheres showed a flexible control over shell thickness, surface charges and hydrodynamic size by adjusting the feedin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.10.013

    authors： Tang H,Guo J,Sun Y,Chang B,Ren Q,Yang W

    更新日期：2011-12-15 00:00:00

  • Sustained and controlled release of herbal medicines: The concept of synchronized release.

    abstract：:Synchronized release, defined as simultaneous release of multiple components while keeping the inter-component ratios steady, is crucial to the design and development of sustained- or controlled-release delivery systems of herbal medicines. A theory of infinite dose dividing is proposed to interpret the rationale behi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2019.01.074

    authors： Chen Z,Zhu Q,Qi J,Lu Y,Wu W

    更新日期：2019-04-05 00:00:00

  • Paediatric formulations--getting to the heart of the problem.

    abstract：:Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules. When medicines are not licensed for children, it is unlikely that there will be a suitable, licensed liquid formulation and so extemporaneous liquid preparations ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.006

    authors： Standing JF,Tuleu C

    更新日期：2005-08-26 00:00:00

  • A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.

    abstract：:Liver dysfunction is associated with a variety of liver diseases, including viral or alcoholic hepatitis, fibrosis, cirrhosis, and portal hypertension. A targeted drug delivery system would be very useful in the treatment of these diseases. We herein describe the development of a system comprised of a new peptide-lipi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.068

    authors： Akhter A,Hayashi Y,Sakurai Y,Ohga N,Hida K,Harashima H

    更新日期：2013-11-01 00:00:00

  • One-pot synthesis of dopamine-conjugated hyaluronic acid/polydopamine nanocomplexes to control protein drug release.

    abstract：:The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. The complexes were prepared with HA of different molecular weights (20 kDa and 200 kDa) and various molar ratios of dopamine and lysozyme, a mod...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.007

    authors： Lim DG,Prim RE,Kang E,Jeong SH

    更新日期：2018-05-05 00:00:00

  • Determination of bisphenol A in water and the medical devices used in hemodialysis treatment.

    abstract：:Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.03.003

    authors： Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

    更新日期：2016-05-30 00:00:00

  • Formation, characterization and pH dependence of rifampicin: heptakis(2,6-di-O-methyl)-β-cyclodextrin complexes.

    abstract：:Rifampicin (Rif) is a broad spectrum antibiotic used as a first line agent in the treatment of mycobacterial infections. However, its low solubility and reduced stability in water limit its bioavailability, thus requiring the use of complex formulations. Here, we present a systematic study of Rif in complex with a met...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.06.015

    authors： Angiolini L,Agnes M,Cohen B,Yannakopoulou K,Douhal A

    更新日期：2017-10-15 00:00:00

  • In vitro and in vivo evaluation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matrices.

    abstract：:The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral absorption study, and compared with a commercial product (slow-K). The results indicating ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00264-8

    authors： Wu PC,Tsai MJ,Huang YB,Chang JS,Tsai YH

    更新日期：2002-08-28 00:00:00

  • Competing for water: A new approach to understand disintegrant performance.

    abstract：:The understanding of tablet disintegration is still incomplete as not all involved factors and processes are known or accounted for. E.g., the negative influence of soluble fillers, on disintegration is usually attributed to increased viscosity due to dissolved filler. When the most common filler, lactose, dissolves, ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.025

    authors： Ekmekciyan N,Tuglu T,El-Saleh F,Muehlenfeld C,Stoyanov E,Quodbach J

    更新日期：2018-09-05 00:00:00

  • Supersaturated controlled release matrix using amorphous dispersions of glipizide.

    abstract：:Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffractio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.072

    authors： Lu Z,Yang Y,Covington RA,Bi YV,Dürig T,Ilies MA,Fassihi R

    更新日期：2016-09-25 00:00:00

  • Passive asymmetric transport of hesperetin across isolated rabbit cornea.

    abstract：:Hesperetin, an aglycone of the flavanone hesperidin, is a potential candidate for the treatment of diabetic retinopathy and macular edema. The purpose of this investigation was to determine solubility, stability and in vitro permeability characteristics of hesperetin across excised rabbit corneas. Aqueous and pH depen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.04.036

    authors： Srirangam R,Majumdar S

    更新日期：2010-07-15 00:00:00

  • Saturated fatty acids and fatty acid esters promote the polymorphic transition of clarithromycin metastable form I crystal.

    abstract：:The phase transition of active pharmaceutical ingredients should be taken into account during manufacturing, processing- and storage, because different crystal forms lead to different physical properties of formulations. The phase transition of clarithromycin (CAM) metastable form I to stable form II was investigated ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.041

    authors： Watanabe M,Mizoguchi M,Aoki H,Iwao Y,Noguchi S,Itai S

    更新日期：2016-10-15 00:00:00

  • Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen.

    abstract：:A novel delivery system based on drug-cyclodextrin (CD) complexation and liposomes has been developed to improve therapeutic effect. Three different means, i.e., co-evaporation (COE), co-ground (GR) and co-lyophilization (COL) and three different CDs (β-CD, HP-β-CD and SBE-β-CD) were contrasted to investigate the char...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.011

    authors： Zhang L,Zhang Q,Wang X,Zhang W,Lin C,Chen F,Yang X,Pan W

    更新日期：2015-08-15 00:00:00

  • Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranes.

    abstract：:This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/vancomycin/gentamicin/lidocaine were separately di...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.010

    authors： Chen DW,Hsu YH,Liao JY,Liu SJ,Chen JK,Ueng SW

    更新日期：2012-07-01 00:00:00

  • Beta-cyclodextrin as a suitable solubilizing agent for in situ absorption study of poorly water-soluble drugs.

    abstract：:To evaluate the intestinal permeability of poorly water-soluble compounds, it is of importance to completely dissolve them in a medium and to avoid precipitation during experiments. This study was undertaken to find an agent possessing a high-solubilizing capacity and exhibiting minimal modulating impact on membrane i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.05.003

    authors： Oda M,Saitoh H,Kobayashi M,Aungst BJ

    更新日期：2004-08-06 00:00:00

  • Evaluation of the mechanical properties and drug release of cross-linked Eudragit films containing metronidazole.

    abstract：:The mechanical properties of casted Eudragit E-100 films were tested for the combined effect of two cohesion promoters (succinic or citric acid) and triacetin as a plasticizer. The prepared films were elastic, self-adhesive, transparent and pale yellow in colour. Films containing either of the tested cohesion promoter...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.03.026

    authors： Elgindy N,Samy W

    更新日期：2009-07-06 00:00:00

  • A novel flunarizine hydrochloride-loaded organogel for intraocular drug delivery in situ: Design, physicochemical characteristics and inspection.

    abstract：:We developed a safe and efficacious drug delivery system for treatment of brain diseases. A novel in-situ gel system was prepared using soybean oil, stearic acid and N-methyl-2-pyrrolidinone (NMP) (10:1:3, v/w/v). This system had low viscosity as a sol in vitro and turned into a solid or semi-solid gel in situ after a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119027

    authors： Dai M,Bai L,Zhang H,Ma Q,Luo R,Lei F,Fei Q,He N

    更新日期：2020-02-25 00:00:00

  • Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan capsules.

    abstract：:In general, absorption enhancing effects of various absorption enhancers were greater in the large intestine than those in the small intestinal regions. Therefore, the effectiveness of absorption enhancers is expected to be remarkably observed, if these enhancers can be delivered to the large intestine with some poorl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.12.017

    authors： Fetih G,Lindberg S,Itoh K,Okada N,Fujita T,Habib F,Artersson P,Attia M,Yamamoto A

    更新日期：2005-04-11 00:00:00

  • Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: in vitro and in vivo evaluation in healthy volunteers.

    abstract：:Phenoporlamine hydrochloride is a novel compound that is used for the treatment of hypertension. The purpose of this study was to develop a sustained release tablet for phenoporlamine hydrochloride because of its short biological half-life. Three floating matrix formulations of phenoporlamine hydrochloride based on ga...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijpharm.2005.12.003

    authors： Xu X,Sun M,Zhi F,Hu Y

    更新日期：2006-03-09 00:00:00