Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications.


:In this study, a novel injectable hydrogel based on iota and kappa carrageenan, locust bean gum and gelatin was prepared for wound healing and tissue repairing applications. This injectable hydrogel was obtained via physical crosslinking. FTIR analysis confirmed the physical interaction between the biopolymeric components of the hydrogel. The prepared injectable hydrogel exhibited shear-thinning characteristics and could be injected for minimally invasive applications. Also, the hydrogel showed a porous structure, physiological and mechanical stability and biocompatibility. The in vitro cell culture studies showed that fibroblasts were able to grow, adhere and spread inside the hydrogel, indicating that hydrogel could support tissue repair. Moreover, hydrogel could be useful for the delivery of biomolecules. Vascular endothelial growth factor was encapsulated within the hydrogel and subsequently released, which accelerated the migration of human umbilical vein endothelial cells and facilitated in vitro wound healing. Overall, the results indicate that hydrogel can be a potential injectable delivery vehicle for wound healing and tissue repair.


Int J Pharm


Pettinelli N,Rodríguez-Llamazares S,Bouza R,Barral L,Feijoo-Bandín S,Lago F




Has Abstract


2020-08-29 00:00:00












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    abstract::The primary purpose of the present study was to design and optimize a liposomal formulation of the poorly water-soluble drug oleanolic acid (OA) to improve its oral bioavailability, and prolong the duration of therapeutic drug level. Liposomes containing a soybean lecithin and cholesterol lipid bilayer, a protective h...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Liu Y,Luo X,Xu X,Gao N,Liu X

    更新日期:2017-01-30 00:00:00

  • Nanoliposome-mediated targeting of antibodies to tumors: IVIG antibodies as a model.

    abstract::Monoclonal antibodies are routinely used as tools in immunotherapies against solid tumors. However, administration of monoclonal antibodies may cause undesired side effects due to their accumulation in non-targeted organs. Nanoliposomes of less than 200 nm can target antibodies to tumors by enhanced permeation and ret...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nikpoor AR,Tavakkol-Afshari J,Gholizadeh Z,Sadri K,Babaei MH,Chamani J,Badiee A,Jalali SA,Jaafari MR

    更新日期:2015-11-10 00:00:00

  • Dual effects of Tween 80 on protein stability.

    abstract::In this paper, we used IL-2 mutein as a model protein and evaluated the effect of Tween 80, a non-ionic surfactant. In summary, we found that the dual effects of Tween 80 on the stability of IL-2SA, such as that shaking-induced aggregation of IL-2 mutein was significantly inhibited in the presence of Tween 80. However...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Wang W,Wang YJ,Wang DQ

    更新日期:2008-01-22 00:00:00

  • Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour.

    abstract::Polysaccharides are suitable for application as hydrophilic matrices because of their ability to hydrate and swell upon contact with fluids, forming a gel layer which controls drug release. When extracted from plants, polysaccharides often contain significant quantities of starch that impacts upon their functional pro...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nep EI,Asare-Addo K,Ghori MU,Conway BR,Smith AM

    更新日期:2015-12-30 00:00:00

  • First explanations for differences in electrotransfection efficiency in vitro and in vivo using spheroid model.

    abstract::Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotransfection is efficient, gene expression in tumoral cells in vivo is weak. To determine reasons for this difference and unravel gene...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Chopinet L,Wasungu L,Rols MP

    更新日期:2012-02-14 00:00:00

  • Double barrier as an effective method for slower delivery rate of ibuprofen.

    abstract::Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-lo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

    更新日期:2014-09-10 00:00:00

  • Improvement of physicochemical properties of N-4472. Part II: characterization of N-4472 microemulsion and the enhanced oral absorption.

    abstract::The optimized formulation of N-4472, N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-[4-(N-benzylpiperidyl)] urea, which was a poorly water-soluble drug, was developed by utilizing the complexation between N-4472 and L-ascorbic acid (VC). It was found that the formulation with Gelucire((R)) 44/14, H...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Itoh K,Matsui S,Tozuka Y,Oguchi T,Yamamoto K

    更新日期:2002-10-10 00:00:00

  • Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets.

    abstract::The effect of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was investigated. The elastic properties of five pharmaceutical products were characterized by their total elastic recovery. To test the interfacial strength of the bilayer tablets a new flexural test was pr...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Busignies V,Mazel V,Diarra H,Tchoreloff P

    更新日期:2013-11-30 00:00:00

  • Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques.

    abstract::This work investigates the impact of vaginal ring size and drug loading on the in vitro release, safety, ease of fit, and pharmacokinetics in cynomolgus macaques of matrix-type silicone elastomer vaginal rings containing a combination of the non-nucleoside reverse transcriptase inhibitor dapivirine and the protease in...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Murphy DJ,Desjardins D,Boyd P,Dereuddre-Bosquet N,Stimmer L,Caldwell A,Le Grand R,Kelly C,van Roey J,Malcolm RK

    更新日期:2018-10-25 00:00:00

  • MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients.

    abstract::In cutaneous drug delivery, it is widely accepted that the choice of excipients affects the delivery of a drug molecule to the skin. MALDI mass spectrometry imaging (MALDI-MSI) is an imaging technique which enables the simultaneous detection of multiple compounds. MALDI-MSI was applied to study the penetration of tofa...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Handler AM,Fallah M,Just Pedersen A,Pommergaard Pedersen G,Troensegaard Nielsen K,Janfelt C

    更新日期:2020-11-30 00:00:00

  • Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.

    abstract::Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

    更新日期:2005-08-26 00:00:00

  • Controlled release from hydrogel-based solid matrices. A model accounting for water up-take, swelling and erosion.

    abstract::Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the reso...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lamberti G,Galdi I,Barba AA

    更新日期:2011-04-04 00:00:00

  • Nanoparticles for direct nose-to-brain delivery of drugs.

    abstract::This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS. This is relevant in the field of drug delivery as well as for new de...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Mistry A,Stolnik S,Illum L

    更新日期:2009-09-08 00:00:00

  • Graphene oxide crosslinked-zein nanofibrous scaffolds for prominent Cu-adsorption as tissue regeneration promoters in diabetic rats: Nanofibers optimization and in vivo assessment.

    abstract::Diabetic ulcers are prone to bacterial contamination and can severely affect patient's quality of life. This study is first report to explore copper-grafted graphene oxide-crosslinked zein scaffolds (Cu-GZS) for promoting cutaneous excision wounds healing as a promising therapeutic modality in diabetic male-rats. Cu-G...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: El-Lakany SA,Kamoun EA,Abd-Elhamid AI,Aly RG,Samy WM,Elgindy NA

    更新日期:2020-11-30 00:00:00

  • Liposome encapsulation of curcumin: physico-chemical characterizations and effects on MCF7 cancer cell proliferation.

    abstract::The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailabilit...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Hasan M,Belhaj N,Benachour H,Barberi-Heyob M,Kahn CJ,Jabbari E,Linder M,Arab-Tehrany E

    更新日期:2014-01-30 00:00:00

  • New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections.

    abstract::In this paper, we report the synthesis, characterization (FT-IR, XRD, BET, HR-TEM) and bioevaluation of a novel γ-aminobutiric acid/silica (noted GABA-SiO₂ or γ-SiO₂) hybrid nanostructure, for the improved release of topical antibiotics, used in the treatment of Staphylococcus aureus infections. GABA-SiO₂ showed IR ba...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Grumezescu AM,Ghitulica CD,Voicu G,Huang KS,Yang CH,Ficai A,Vasile BS,Grumezescu V,Bleotu C,Chifiriuc MC

    更新日期:2014-03-25 00:00:00

  • Skin penetration enhancement of mefenamic acid by ethanol and 1,8-cineole can be explained by the 'pull' effect.

    abstract::The simultaneous skin permeation of drug and penetration enhancer have been studied in vitro. Simple formulations of mefenamic acid in PEG400 incorporating various proportions of ethanol or 1,8-cineole were prepared and applied to porcine ear skin in diffusion cells under infinite conditions. Receptor phases were assa...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Heard CM,Kung D,Thomas CP

    更新日期:2006-09-14 00:00:00

  • Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

    abstract::In this report, we investigated the combined effect of drug liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate (ISN) in rat abdominal skin in vitro. Occlusive application of both liposomal and aqueous ISN solution, with and without addition of 5% glycerol, showed that drug li...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Barichello JM,Yamakawa N,Kisyuku M,Handa H,Shibata T,Ishida T,Kiwada H

    更新日期:2008-06-05 00:00:00

  • The influence of formulation variables on in vitro transfection efficiency and physicochemical properties of chitosan-based polyplexes.

    abstract::The aim of this study was to investigate how a selection of formulation variables affects the in vitro transfection efficiency and physicochemical properties (particle size, zetapotential and chitosan-plasmid association) of chitosan-based polyplexes. Experimental designs in combination with multivariate data analysis...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Romøren K,Pedersen S,Smistad G,Evensen Ø,Thu BJ

    更新日期:2003-08-11 00:00:00

  • Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates.

    abstract::Oridonin (ORI), a diterpenoid compound with promising antitumor activity, was proved to possess potent antileukemia efficacies in vitro and in vivo recently. However, the development and application of ORI was limited by its poor solubility and rapid plasma clearance. The purpose of this study was to solve these probl...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Shen J,Zhang D,Zhao Z,Jia L,Zheng D,Liu G,Hao L,Zhang Q,Tian X,Li C,Guo H

    更新日期:2013-11-01 00:00:00

  • Functionalized single-walled carbon nanotubes: cellular uptake, biodistribution and applications in drug delivery.

    abstract::The unique properties of single-walled carbon nanotubes (SWNTs) enable them to play important roles in many fields. One of their functional roles is to transport cargo into cell. SWNTs are able to traverse amphipathic cell membranes due to their large surface area, flexible interactions with cargo, customizable dimens...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Li Z,de Barros ALB,Soares DCF,Moss SN,Alisaraie L

    更新日期:2017-05-30 00:00:00

  • Development and application of high throughput plasma stability assay for drug discovery.

    abstract::Plasma stability plays an important role in drug discovery and development. Unstable compounds tend to have rapid clearance and short half-life, resulting in poor in vivo performance. This paper examines the variables that affect the plasma stability assay results, including substrate concentration, %DMSO, plasma conc...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Di L,Kerns EH,Hong Y,Chen H

    更新日期:2005-06-13 00:00:00

  • Carrier mediated uptake of L-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)--strategy for the design of transporter/receptor targeted prodrugs.

    abstract::The objective of this study was to investigate the presence of amino acid transporters on the corneal epithelium and to enhance corneal drug absorption through prodrug modification targeted to the amino acid transporters. SIRC was used as a model cell line representing the corneal epithelium. Uptake studies were carri...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Balakrishnan A,Jain-Vakkalagadda B,Yang C,Pal D,Mitra AK

    更新日期:2002-10-24 00:00:00

  • Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate.

    abstract::D-glucosamine and chitosan were modified by the immobilization of thiol groups utilizing 2-iminothiolane. The toxicity profile of the resulting D-glucosamine-TBA (4-thiobutylamidine) conjugate, of chitosan-TBA conjugate and of the corresponding unmodified controls was evaluated in vitro. On the one hand, the cell memb...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Guggi D,Langoth N,Hoffer MH,Wirth M,Bernkop-Schnürch A

    更新日期:2004-07-08 00:00:00

  • Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics.

    abstract::A substantial drug release from poly(lactic-co-glycolic) acid (PLGA) micro- and nanoparticles can occur in the first hours of immersion, which is referred to as burst release. A strong burst release (when not intentional) is to be avoided as it decreases the efficacy of the treatment and could be dangerous to the host...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Rodrigues de Azevedo C,von Stosch M,Costa MS,Ramos AM,Cardoso MM,Danhier F,Préat V,Oliveira R

    更新日期:2017-10-30 00:00:00

  • Sustained intrathecal therapeutic protein delivery using genetically transduced tissue implants in a freely moving rat model.

    abstract::Systemic delivery of therapeutic proteins to the central nervous system (CNS) is challenging because of the blood-brain barrier restrictions. Direct intrathecal delivery is possible but does not produce stable concentrations. We are proposing an alternative approach for localized delivery into the CNS based on the Tra...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Aronson JP,Katnani HA,Pomerantseva I,Shapir N,Tse H,Miari R,Goltsman H,Mwizerwa O,Neville CM,Neil GA,Eskandar EN,Sundback CA

    更新日期:2017-12-20 00:00:00

  • Preparation, characterization, and optimization of asenapine maleate mucoadhesive nanoemulsion using Box-Behnken design: In vitro and in vivo studies for brain targeting.

    abstract::The tight junctions between capillary endothelial cells of the blood-brain barrier (BBB) restricts the entry of therapeutics into the brain. Potential of the intranasal delivery tool has been explored in administering the therapeutics directly to the brain, thus bypassing BBB. The objective of this study was to develo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kumbhar SA,Kokare CR,Shrivastava B,Gorain B,Choudhury H

    更新日期:2020-08-30 00:00:00

  • Evaluation of alkyloxycarbonyloxymethyl (AOCOM) ethers as novel prodrugs of phenols for topical delivery: AOCOM prodrugs of acetaminophen.

    abstract::The maximum fluxes of a series of alkyloxycarbonyloxymethyl (AOCOM) ethers of acetaminophen (APAP) through hairless mouse skin from isopropyl myristate, IPM (J(MMIPM)) were measured. The J(MMIPM), solubilities in IPM (S(IPM)), water (S(AQ)) and pH 4.0 buffer (S4.0) and molecular weights MW were then fitted to the Robe...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Thomas JD,Sloan KB

    更新日期:2009-04-17 00:00:00

  • Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids.

    abstract::The permeation of cyproterone acetate (CPA) from Derma Membrane Structure (DMS) creams and liposomal formulations was investigated. Standard diffusion experiments with dermatomed porcine skin were performed. The cumulative CPA amount permeated of the DMS creams was between 2.9 and 6.8 microg/cm(2) within 48 h. By addi...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Valenta C,Janisch M

    更新日期:2003-06-04 00:00:00

  • Investigation of surfactants suitable for stabilizing of latanoprost.

    abstract::The content of latanoprost, a therapeutic drug for glaucoma, is likely to decrease in solution. In a previous study, we confirmed that this was associated with latanoprost adsorption to the container and hydrolysis of latanoprost, and established a formulation of latanoprost eye drop solution that can be stored at roo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ochiai A,Ohkuma M,Danjo K

    更新日期:2012-10-15 00:00:00