当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Protein assembled nano-vehicle entrapping photosensitizer molecules for efficient lung carcinoma therapy.

Protein assembled nano-vehicle entrapping photosensitizer molecules for efficient lung carcinoma therapy.

Abstract：

:The efficiency of drug depends not only on its potency but also on its ability to reach the target sites in preference to non-target sites. In this regard, protein assembled nanocarrier is the most promising strategy for intracellular anti-cancer drug delivery. The key motive of this study is to fabricate biocompatible protein assembled nanocarrier conjugated photosensitizer system for stimuli-responsive treatment of lung carcinoma. Here, we have synthesized a unique nanohybrid of protein assembled gold nanoparticles (AuNPs), attaching a model photosensitizer, Protoporphyrin IX (PpIX) to the protein shell of the nanoparticles (NPs) imparting an ideal drug-carrier nature. Photo-induced alteration in hydrodynamic diameter suggests structural perturbation of the nanohybrid which in terms signifies on-demand drug delivery. The drug release profile has been further confirmed by using steady-state fluorescence experiments. AuNP-PpIX showed excellent anti-cancer efficiency upon green light irradiation on lung adenocarcinoma cell line (A549) through intracellular reactive oxygen species (ROS) generation. The cellular morphological changes upon PDT and internalization of nanohybrid were monitored using confocal laser scanning microscope. This anti-cancer effect of nanohybrid was associated with apoptotic pathway which was confirmed in the flow cytometric platform. The developed nanomedicine is expected to find relevance in clinical anti-cancer PDT models in the near future.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Nag S,Bagchi D,Chattopadhyay D,Bhattacharyya M,Pal SK

doi

10.1016/j.ijpharm.2020.119192

subject

Has Abstract

pub_date

2020-04-30 00:00:00

pages

119192

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)30176-9

journal_volume

580

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Short-term delayed-release microcapsules spraycoated with acrylic terpolymers.

    abstract：:A series of poly(ethyl acrylate (EA)/methyl methacrylate (MMA)/2-hydroxyethyl methacrylate (HEMA)) lattices were synthesized to prepare short-term delayed-release microcapsules by employing the Wurster coating process. Latex with a HEMA molar fraction exceeding 60% could not be synthesized as an aqueous suspension due...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.10.020

    authors： Liu D,Ichikawa H,Cui F,Fukumori Y

    更新日期：2006-01-13 00:00:00

  • Double barrier as an effective method for slower delivery rate of ibuprofen.

    abstract：:Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-lo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.06.037

    authors： Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

    更新日期：2014-09-10 00:00:00

  • A systematic review of the use of dosage form manipulation to obtain required doses to inform use of manipulation in paediatric practice.

    abstract：:This study sought to determine whether there is an evidence base for drug manipulation to obtain the required dose, a common feature of paediatric clinical practice. A systematic review of the data sources, PubMed, EMBASE, CINAHL, IPA and the Cochrane database of systematic reviews, was used. Studies that considered t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2016.12.032

    authors： Richey RH,Hughes C,Craig JV,Shah UU,Ford JL,Barker CE,Peak M,Nunn AJ,Turner MA

    更新日期：2017-02-25 00:00:00

  • Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications.

    abstract：:In this study, a novel injectable hydrogel based on iota and kappa carrageenan, locust bean gum and gelatin was prepared for wound healing and tissue repairing applications. This injectable hydrogel was obtained via physical crosslinking. FTIR analysis confirmed the physical interaction between the biopolymeric compon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119828

    authors： Pettinelli N,Rodríguez-Llamazares S,Bouza R,Barral L,Feijoo-Bandín S,Lago F

    更新日期：2020-08-29 00:00:00

  • Roll compaction process modeling: transfer between equipment and impact of process parameters.

    abstract：:In this study, the roll compaction of an intermediate drug load formulation was performed using horizontally and vertically force fed roll compactors. The horizontally fed roll compactor was equipped with an instrumented roll technology allowing the direct measurement of normal stress at the roll surface, while the ve...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.02.042

    authors： Souihi N,Reynolds G,Tajarobi P,Wikström H,Haeffler G,Josefson M,Trygg J

    更新日期：2015-04-30 00:00:00

  • Technical aspects of preparing PEG-PLGA nanoparticles as carrier for chemotherapeutic ‎agents by nanoprecipitation method.

    abstract：:Nanoprecipitation is a simple and increasingly trending method for nanoparticles preparation. The self-assembly feature of poly (ethylene glycol)-poly (lactide-co-glycolic acid) (PEG-PLGA) amphiphilic copolymer into a nanoparticle and its versatile structure makes nanoprecipitation one of the best methods for its prep...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.09.054

    authors： Almoustafa HA,Alshawsh MA,Chik Z

    更新日期：2017-11-25 00:00:00

  • Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin.

    abstract：:The objective of this study was to determine the effect of iontophoresis on the delivery of terbinafine hydrochloride (4%, w/w) into and across hairless rat skin. In vitro skin uptake and permeation studies were performed using Franz diffusion cells. Anodal iontophoresis was applied for 1h at current densities of 0.2,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.12.029

    authors： Sachdeva V,Siddoju S,Yu YY,Kim HD,Friden PM,Banga AK

    更新日期：2010-03-30 00:00:00

  • In-vitro and particle image velocimetry studies of dry powder inhalers.

    abstract：:Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug losses in the mouth-throat region. Aerosol efficiency of DPIs is closely related to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119966

    authors： Dos Reis LG,Chaugule V,Fletcher DF,Young PM,Traini D,Soria J

    更新日期：2021-01-05 00:00:00

  • Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques.

    abstract：:This work investigates the impact of vaginal ring size and drug loading on the in vitro release, safety, ease of fit, and pharmacokinetics in cynomolgus macaques of matrix-type silicone elastomer vaginal rings containing a combination of the non-nucleoside reverse transcriptase inhibitor dapivirine and the protease in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.051

    authors： Murphy DJ,Desjardins D,Boyd P,Dereuddre-Bosquet N,Stimmer L,Caldwell A,Le Grand R,Kelly C,van Roey J,Malcolm RK

    更新日期：2018-10-25 00:00:00

  • Systematic modifications of amino acid-based organogelators for the investigation of structure-property correlations in drug delivery system.

    abstract：:Thermogels, used as multi-functional drug-loading materials, have properties that mainly rely on their gelator structure. Although a large variety of organogel systems are used as drug delivery carriers, relatively few have been investigated in terms of their structure-property correlations based on amino acid derivat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.043

    authors： Hu B,Sun W,Li H,Sui H,Li S

    更新日期：2018-08-25 00:00:00

  • Delivery of FK506-loaded PLGA nanoparticles prolongs cardiac allograft survival.

    abstract：:In this study, FK506-loaded poly(lactide-co-glycolide) nanoparticles (PLGA-FK506-NPs) were developed using an O/W emulsion solvent evaporation method. The PLGA-FK506-NPs were observed to be monodispersed and spherical by transmission and scanning electron microscopy. The mean size and zeta potential measured by dynami...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118951

    authors： Deng C,Chen Y,Zhang L,Wu Y,Li H,Wu Y,Wang B,Sun Z,Li Y,Lv Q,Yang Y,Wang J,Jin Q,Xie M

    更新日期：2020-02-15 00:00:00

  • Solubility-physicochemical-thermodynamic theory of penetration enhancer mechanism of action.

    abstract：:The hypothesis for the investigation was that the overall mechanism of action of skin penetration enhancers is best explained by the Solubility-Physicochemical-Thermodynamic (SPT) theory. To our knowledge, this is the first report of the application of SPT theory in transdermal/topical/enhancer research. The SPT theor...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118920

    authors： Haq A,Chandler M,Michniak-Kohn B

    更新日期：2020-02-15 00:00:00

  • General procedure to aid the development of continuous pharmaceutical processes using multivariate statistical modeling - an industrial case study.

    abstract：:Streamlining the manufacturing process has been recognized as a key issue to reduce production costs and improve safety in pharmaceutical manufacturing. Although data available from earlier developmental stages are often sparse and unstructured, they can be very useful to improve the understanding about the process un...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.01.018

    authors： Tomba E,De Martin M,Facco P,Robertson J,Zomer S,Bezzo F,Barolo M

    更新日期：2013-02-28 00:00:00

  • Preparation and characterization of the ion-fixed mixed micelles with superior stability.

    abstract：:The inherent instability of micelles remains a main challenge for antitumor drug delivery, the objective of this study is to prepare and characterize the ion-fixed mixed micelles with significantly improved stability. The mixed micelles and ion-fixed mixed micelles combining the carboxy-containing PLA (PLA-COO(-)) and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.011

    authors： Li Y,Fu Y,Guo H,Zhang L,Huang L,Yang L

    更新日期：2015-07-15 00:00:00

  • Preparation of 4-arm star PELA and its encapsulation of rotavirus for drug delivery.

    abstract：:A relatively high molecular weight of 4-arm star PELA was obtained by ring-opening polymerization of l-lactic acid O-carboxyanhydride with 4-arm-PEG in the presence of DMAP as an initiator. The results via(1)H NMR and (13)C NMR show that the end of the star PELA chain is a hydroxyl group and the central core is a PEG ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.074

    authors： Qingcong L,Xiaoxia P,Hongli L,Minglong Y

    更新日期：2015-08-01 00:00:00

  • 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems.

    abstract：:Three-dimensional printing includes a wide variety of manufacturing techniques, which are all based on digitally-controlled depositing of materials (layer-by-layer) to create freeform geometries. Therefore, three-dimensional printing processes are commonly associated with freeform fabrication techniques. For years, th...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2015.12.071

    authors： Goole J,Amighi K

    更新日期：2016-02-29 00:00:00

  • Robustness testing, using experimental design, of a flow-through dissolution method for a product where the actives have markedly differing solubility properties.

    abstract：:The use of experimental design for the robustness testing of a flow-through dissolution method (Ph Eur/USP Apparatus 4) for atovaquone, one of the drug substances in a dual-active anti-malarial tablet formulation, Malarone tablets, is described. This procedure was developed to overcome the suppression of the atovaquon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00509-3

    authors： Bloomfield MS,Butler WC

    更新日期：2000-09-25 00:00:00

  • Preparation and investigation of core-shell nanoparticles containing human interferon-α.

    abstract：:Sustained release of active interferon-α (IFN-α) has been achieved from core-shell nanoparticles (NPs) prepared by aqueous precipitation of IFN-α-enriched human serum albumin (HSA-IFN-α) and layer-by-layer (L-b-L) by coating of the IFN-α NPs with poly(sodium-4-styrene) sulphonate (PSS) and chitosan (Chit). The concent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118825

    authors： Kristó K,Szekeres M,Makai Z,Márki Á,Kelemen A,Bali L,Pallai Z,Dékány I,Csóka I

    更新日期：2020-01-05 00:00:00

  • Impact of controlled vacuum induced surface freezing on the freeze drying of human plasma.

    abstract：:During the freezing step of a typical freeze drying process, the temperature at which nucleation is induced is generally stochastically distributed, resulting in undesired within-batch heterogeneity. Controlled nucleation techniques have been developed to address this problem; these make it possible to trigger the for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119290

    authors： Arsiccio A,Matejtschuk P,Ezeajughi E,Riches-Duit A,Bullen A,Malik K,Raut S,Pisano R

    更新日期：2020-05-30 00:00:00

  • Engineered DNA nanodrugs alleviate inflammation in inflammatory arthritis.

    abstract：:Rheumatoid arthritis (RA) is an autoimmune disease featured with chronic joint inflammation. Suppression of inflammation is critical to RA treatment and joint protection. In this study, DNA nanodrugs are prepared via the conjugation of NF-κB decoy oligodeoxynucleotides (dODNs) and VCAM-1 targeted peptides (P) onto sel...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119047

    authors： Wang Z,Chu X,Li N,Fu L,Gu H,Zhang N

    更新日期：2020-03-15 00:00:00

  • Formulation and evaluation of novel reverse microemulsions containing salmon calcitonin in hydrofluoroalkane propellants.

    abstract：:To develop reverse microemulsion as a potential strategy for pulmonary delivery of salmon calcitonin (sCT) in HFA134a propellant of pressurized metered dose inhalers (pMDIs), pluronic P85 (P85) was chosen as the most appropriate surfactant to form microemulsions containing sCT. Formulation parameters, including the su...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.03.032

    authors： Shan Z,Tan Y,Qin L,Li G,Pan X,Wang Z,Yu X,Wang Q,Wu C

    更新日期：2014-05-15 00:00:00

  • Impact of blend properties on die filling during tableting.

    abstract：:Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying paddle speed and turret speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.015

    authors： Van Snick B,Grymonpré W,Dhondt J,Pandelaere K,Di Pretoro G,Remon JP,De Beer T,Vervaet C,Vanhoorne V

    更新日期：2018-10-05 00:00:00

  • Elaborations on the Higuchi model for drug delivery.

    abstract：:The Higuchi model for the rate of drug release from matrix devices where the drug loading exceeds the solubility in the matrix medium, whose 50-year anniversary is celebrated in this issue, has proven to be a robust framework and an invaluable tool in developing a significant part of the modern controlled drug deliver...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.10.037

    authors： Paul DR

    更新日期：2011-10-10 00:00:00

  • Transdermal permeation enhancement of N-trimethyl chitosan for testosterone.

    abstract：:The aim of this study was to evaluate the transdermal permeation enhancement of N-trimethyl chitosan (TMC) with different degrees of quaternization (DQ). TMCs with DQ of 40 and 60% (TMC40 and TMC60) were synthesized and characterized by (1)H NMR. Testosterone (TS) used as an effective drug, four different gels were pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.050

    authors： He W,Guo X,Zhang M

    更新日期：2008-05-22 00:00:00

  • Statistical testing of drug accumulation in skin tissues by linear regression versus contents of stratum corneum lipids.

    abstract：:This investigation is a contribution to standardization in in vitro drug penetration measurements using excised human skin and to statistical treatment of the observations. The wide variations observed in measurements of drug accumulation in and drug permeation through the stratum corneum are caused not only by analyt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00558-5

    authors： Loth H,Hauck G,Borchert D,Theobald F

    更新日期：2000-11-19 00:00:00

  • Differences in physical chemistry and dissolution rate of solid particle aerosols from solution pressurised inhalers.

    abstract：:Solution composition alters the dynamics of beclomethasone diproprionate (BDP) particle formation from droplets emitted by pressurised metered dose inhalers (pMDIs). The hypothesis that differences in inhaler solutions result in different solid particle physical chemistry was tested using a suite of complementary calo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.01.033

    authors： Buttini F,Miozzi M,Balducci AG,Royall PG,Brambilla G,Colombo P,Bettini R,Forbes B

    更新日期：2014-04-25 00:00:00

  • Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination.

    abstract：:This work reports a novel approach to the assessment of the surface properties of compacts used in Surface Dissolution Imaging (SDI). SDI is useful for determining intrinsic dissolution rate (IDR), an important parameter in early stage drug development. Surface topography, post-compaction and post-SDI run, have been m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.053

    authors： Ward A,Walton K,Box K,Østergaard J,Gillie LJ,Conway BR,Asare-Addo K

    更新日期：2017-09-15 00:00:00

  • Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation.

    abstract：:The present study investigated the ability of a polyelectrolyte complex (CS/CMCS-NPs), composed of chitosan (CS) and o-carboxymeymethy chitosan (CMCS) as a pH responsive carrier for oral delivery of doxorubicin hydrochloride (DOX). The obtained CS/CMCS-NPs were characterized for various parameters including morphology...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.079

    authors： Feng C,Wang Z,Jiang C,Kong M,Zhou X,Li Y,Cheng X,Chen X

    更新日期：2013-11-30 00:00:00

  • Determination of bisphenol A in water and the medical devices used in hemodialysis treatment.

    abstract：:Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.03.003

    authors： Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

    更新日期：2016-05-30 00:00:00

  • Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

    abstract：:The objectives of this work were to develop a liposomal fasudil, an antivasospastic drug, as a possible means to deliver the encapsulated drug to the brain, and to characterize the stability of the liposomal formulation in vitro. Transmembrane electrochemical gradients of H+ or ammonium sulfate were created, and their...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00896-1

    authors： Ishida T,Takanashi Y,Doi H,Yamamoto I,Kiwada H

    更新日期：2002-01-31 00:00:00