Abstract：
:DNA as a novel biomaterial can be used to fabricate different kinds of DNA nanostructures based on its principle of GC/AT complementary base pairing. Studies have shown that DNA nanostructure is a nice drug carrier to overcome big obstacles existing in cancer therapy such as systemic toxicity and unsatisfied drug efficacy. Thus, different types of DNA nanostructure-based drug delivery nanosystems have been designed in cancer therapy. To improve treating efficacy, they are also developed into more functional drug delivery nanosystems. In recent years, some important progresses have been made. The objective of this review is to make a retrospect and summary about these different kinds of DNA nanostructure-based drug delivery nanosystems and their latest progresses: (1) active targeting; (2) mutidrug co-delivery; (3) construction of stimuli-responsive/intelligent nanosystems.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Wu D,Wang L,Li W,Xu X,Jiang Wdoi
10.1016/j.ijpharm.2017.09.032subject
Has Abstractpub_date
2017-11-25 00:00:00pages
169-178issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30898-0journal_volume
533pub_type
杂志文章,评审abstract：:Design and realization of drug delivery systems based on polymer matrices could be greatly improved by modeling the phenomena which take place after the systems administration. Availability of a reliable mathematical model, able to predict the release kinetic from drug delivery systems, could actually replace the reso...
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更新日期：2019-03-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2018-02-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2004.11.028
更新日期：2005-02-16 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-04-16 00:00:00
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