Abstract:
:Superparamganetic iron oxide-based contrast agents in magnetic resonance imaging (MRI) have offered new possibility for early detection of lymph nodes and their metastases. According to important role of nanoparticle size in biodistribution, magnetite nanoparticles coated with different polyethylene glycol (PEG) concentrations up to 10/1 PEG/iron oxide weight ratio in an ex situ manner. To predict the PEG-coated nanoparticle behavior in biological media, such as blood stream or tissue, colloidal stability evaluation was performed to estimate the coating endurance in different conditions. Accordingly, optical absorbance measurements were conducted in solutions with different values of pH and NaCl concentrations. The results indicated that at neutral pH condition, nanoparticles treated by 3/1 ratio possessed better stability parameters. Investigating at high pH of 10 resulted in superior stability for bare magnetite nanoparticles due to its higher electrophoretic mobility. Coating material was attacked at acidic solutions which cause samples with higher PEG weight ratio to be settled slower. In various ionic strengths of 10(-5) to 0.1 M, 3/1 ratio samples offered greater resistivity to sedimentation. The nanoparticles were further investigated by exposure to L929 cell and following up the iron uptake within cells. Finally, detection sensitivities in lymph nodes were evaluated. Particle uptake and the most signal reduction for in vivo MRI studies were also obtained by nanoparticles acquiring lower PEG contents that showed better colloidal stability.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Masoudi A,Madaah Hosseini HR,Shokrgozar MA,Ahmadi R,Oghabian MAdoi
10.1016/j.ijpharm.2012.04.080subject
Has Abstractpub_date
2012-08-20 00:00:00pages
129-41issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(12)00456-5journal_volume
433pub_type
杂志文章abstract::Conventional nebulisation has the disadvantages of low aerosol output rate and potential damage to macromolecules due to high shear (jet nebulisation) or cavitation (ultrasonic nebulisation). HYDRA (HYbriD Resonant Acoustics) technology has been shown to overcome these problems by using a hybrid combination of surface...
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journal_title:International journal of pharmaceutics
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abstract::The tight junctions between capillary endothelial cells of the blood-brain barrier (BBB) restricts the entry of therapeutics into the brain. Potential of the intranasal delivery tool has been explored in administering the therapeutics directly to the brain, thus bypassing BBB. The objective of this study was to develo...
journal_title:International journal of pharmaceutics
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abstract::To enhance the medicinal activity of bee venom (BV) acupuncture, bee venom was loaded into biodegradable poly(D,L-lactide-co-glycolide) nanoparticles (BV-PLGA-NPs) by a water-in-oil-in-water-emulsion/solvent-evaporation technique. Rat formalin tests were performed after subcutaneous injection of BV-PLGA-NPs to the Zus...
journal_title:International journal of pharmaceutics
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abstract::Docetaxel (DTX) is one of the important antitumor drugs, being used in several common chemotherapies to control leading cancer types. Severe toxicities of the DTX are prominent due to sudden parenteral exposure of desired loading dose to maintain the therapeutic concentration. Field of nanotechnology is leading to res...
journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2017.05.041
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journal_title:International journal of pharmaceutics
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abstract::The relationships between data of passage through Caco-2 cultured cell lines (log Papp), taken from the literature, for 38 structurally unrelated compounds and both n-octanol lipophilicity parameters (log P(N) and log D(7.4)) and phospholipid affinity indexes were investigated. Phospholipid affinity(log k W(IAM)) was ...
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2000-09-25 00:00:00