Abstract：
:Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such compounds must be improved in order to allow imaging of the smallest airways. Here, diatrizoic acid nanoparticle agglomerates were created by assembling nanoparticles into inhalable microparticles that may augment deposition in the lung periphery. Nanoparticle agglomerates were fully characterized and safety was determined in vivo. After dry powder insufflation to rats, no acute alveolar tissue damage was observed 2h post-dose. Diatrizoic acid nanoparticle agglomerates possess the characteristics of an efficient and safe inhalable lung contrast agent.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
El-Gendy N,Aillon KL,Berkland Cdoi
10.1016/j.ijpharm.2010.03.009subject
Has Abstractpub_date
2010-05-31 00:00:00pages
305-12issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(10)00183-3journal_volume
391pub_type
杂志文章abstract：:The increasing realisation of the impact of size and surface properties on the bio-distribution of drug loaded colloidal particles has driven the application of micro fabrication technologies for the precise engineering of drug loaded microparticles. This paper demonstrates an alternative approach for producing size c...
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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