当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes.

Abstract：

:The objectives of this work were to develop a liposomal fasudil, an antivasospastic drug, as a possible means to deliver the encapsulated drug to the brain, and to characterize the stability of the liposomal formulation in vitro. Transmembrane electrochemical gradients of H+ or ammonium sulfate were created, and their effect on the uptake of fasudil into preformed hydrogenated soy phosphatidylcholine/cholesterol (HSPC/CHOL) liposomes were examined. Fasudil was successfully loaded into preformed liposomes in response to sulfate ion (SO4(2-)) and, in part, by H+. Encapsulation levels approaching 100% could be achieved up to a drug to lipid ratio of 0.364 (mol/mol). A stability study of the fasudil-loaded liposomes was performed by storage at 4 degrees C in 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid (HEPES)-buffer (pH 7.4) and by incubation in human cerebrospinal fluid (CSF) at 37 degrees C. The formulations were stable with respect to drug retention as well as size alteration, for the period studied. A leakage study clearly showed the sustained release properties of the fasudil-loaded liposomes in human CSF. We recently reported that the intrathecal administration of liposomal fasudil significantly decreased ischemia, with no obvious adverse effect in a rat model [Neurol. Med. Chir. 41 (2001) 109]. Taken together, efficient encapsulation of fasudil into preformed liposomes, their long-term stability at 4 degrees C and the sustained release characteristics in CSF indicate that fasudil-loaded liposomes could be potential candidates for further clinical evaluation.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ishida T,Takanashi Y,Doi H,Yamamoto I,Kiwada H

doi

10.1016/s0378-5173(01)00896-1

keywords:

subject

Has Abstract

pub_date

2002-01-31 00:00:00

pages

59-67

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378517301008961

journal_volume

232

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Effects of permeation enhancers on flufenamic acid delivery in Ex vivo human skin by confocal Raman microscopy.

    abstract：:For effective topical delivery, a drug must cross the stratum corneum (SC) barrier into viable tissue. The use of permeation enhancers is a widespread approach for barrier modification. In the current study, flufenamic acid (FluA), a non-steroidal anti-inflammatory drug, is a model agent for investigating the influenc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.04.011

    authors： Pyatski Y,Zhang Q,Mendelsohn R,Flach CR

    更新日期：2016-05-30 00:00:00

  • Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces.

    abstract：:Acylation of proteins with a fatty acid chain has proven useful for prolonging the plasma half-lives of proteins. In formulation of acylated protein drugs, knowledge about the effect of acylation with fatty acids on the adsorption behaviour of proteins at interfaces will be valuable. The aim of this work was to study ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.01.040

    authors： Pinholt C,Kapp SJ,Bukrinsky JT,Hostrup S,Frokjaer S,Norde W,Jorgensen L

    更新日期：2013-01-02 00:00:00

  • Heparin-functionalized chitosan-alginate scaffolds for controlled release of growth factor.

    abstract：:Controlled long-term release of basic fibroblast growth factor (bFGF) has shown a combined effect on the stimulation of regenerating a number of tissues including cartilage, nerve, skin and liver. In this study, three-dimensional scaffolds prepared from the polyelectrolyte complexes (PEC) of chitosan and alginate were...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.048

    authors： Ho YC,Mi FL,Sung HW,Kuo PL

    更新日期：2009-07-06 00:00:00

  • Influence of ethanol on aspirin release from hypromellose matrices.

    abstract：:Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.09.055

    authors： Roberts M,Cespi M,Ford JL,Dyas AM,Downing J,Martini LG,Crowley PJ

    更新日期：2007-03-06 00:00:00

  • Characterization and antimicrobial activity of a pharmaceutical microemulsion.

    abstract：:The characterization of a pharmaceutical microemulsion system with glycerol monolaurate as oil, ethanol as cosurfactant, Tween 40 as surfactant, sodium diacetate and water, and the antimicrobial activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger and Penic...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.05.022

    authors： Zhang H,Cui Y,Zhu S,Feng F,Zheng X

    更新日期：2010-08-16 00:00:00

  • Magnetic nanoparticles: In vivo cancer diagnosis and therapy.

    abstract：:Recently, significant research efforts have been devoted to the finding of efficient approaches in order to reduce the side effects of traditional cancer therapy and diagnosis. In this context, magnetic nanoparticles have attracted much attention because of their unique physical properties, magnetic susceptibility, bi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2015.07.059

    authors： Lima-Tenório MK,Pineda EA,Ahmad NM,Fessi H,Elaissari A

    更新日期：2015-09-30 00:00:00

  • Downstream drug product processing of itraconazole nanosuspension: Factors influencing drug particle size and dissolution from nanosuspension-layered beads.

    abstract：:There is more research required to broaden the knowledge on the downstream processing of nanosuspensions into solid oral dosage forms, especially for coated nanosuspensions onto beads as carriers. This study focuses on bead layering as one approach to solidify nanosuspensions. The aim was to systematically investigate...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.04.012

    authors： Parmentier J,Tan EH,Low A,Möschwitzer JP

    更新日期：2017-05-30 00:00:00

  • Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms.

    abstract：:In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion spheronization and ER characteristics were obtained after fluid bed ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.049

    authors： Schrank S,Jedinger N,Wu S,Piller M,Roblegg E

    更新日期：2016-07-25 00:00:00

  • In vitro simulation of drug intestinal absorption.

    abstract：:In this work, a simple set-up was designed, realized and tested to evaluate the effect of intestinal absorption on the in vitro drug release studies. The conventional USP-approved dissolution apparatus 2 was equipped with an hollow fibers filter, along with the necessary tubing and pumps, to simulate the two-fluids re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.10.012

    authors： Lamberti G,Cascone S,Iannaccone M,Titomanlio G

    更新日期：2012-12-15 00:00:00

  • Microagglomeration of pulverized pharmaceutical powders using the Wurster process I. Preparation of highly drug-incorporated, subsieve-sized core particles for subsequent microencapsulation by film-coating.

    abstract：:A novel agglomeration process of pulverized pharmaceutical powders into subsieve-sized agglomerates (microagglomeration) was designed for manufacturing highly drug-incorporated core particles for subsequent microencapsulation by film-coating. The microagglomeration of pulverized phenacetin powder, whose mass median di...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00006-x

    authors： Ichikawa H,Fukumori Y

    更新日期：1999-04-15 00:00:00

  • Evaluation of ISCOM matrices clearance from rabbit nasal cavity by γ scintigraphy.

    abstract：:Immune stimulating complexes and/or ISCOM matrices (adjuvant nanoparticles without antigen as a structural component) found potential applications as nasal vaccine adjuvant/delivery system owing to virus like particulate structure and saponin as potent Th1 adjuvant. One of important limiting factor for nasal vaccine d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.07.051

    authors： Pandey RS,Babbar AK,Kaul A,Mishra AK,Dixit VK

    更新日期：2010-10-15 00:00:00

  • Controlling granule size by granulation liquid feed pulsing.

    abstract：:The effects of inlet air humidity, granulation liquid feed rate and granulation liquid feed pulsing on the particle-size distribution of final granules were studied in a laboratory scale fluid-bed granulator using a central composite study design. The factors examined were modelled using three different particle-size ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.060

    authors： Närvänen T,Lipsanen T,Antikainen O,Räikkönen H,Yliruusi J

    更新日期：2008-06-05 00:00:00

  • Evaluation of childhood exposure to di(2-ethylhexyl) phthalate from perfusion kits during long-term parenteral nutrition.

    abstract：:Leachability of the plasticizer di(2-ethylhexyl) phthalate (DEHP) from administration sets into intravenous parenteral emulsions containing fat was investigated. DEHP is added to polyvinyl chloride (PVC) to impart flexibility. However, DEHP is a lipid-soluble suspected carcinogen that is hepatotoxic and teratogenic in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00335-1

    authors： Kambia K,Dine T,Gressier B,Bah S,Germe AF,Luyckx M,Brunet C,Michaud L,Gottrand F

    更新日期：2003-08-27 00:00:00

  • Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media.

    abstract：:The objective of this study was to investigate the integrtity and stability of oral liposomes containing glycocholate (SGC-Lip) in simulated gastrointestinal (GI) media and ex vivo GI media from rats in comparison with conventional liposomes (CH-Lip) composed of soybean phosphatidylcholine and cholesterol. Membrane in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.10.025

    authors： Hu S,Niu M,Hu F,Lu Y,Qi J,Yin Z,Wu W

    更新日期：2013-01-30 00:00:00

  • Key parameters affecting the initial release (burst) and encapsulation efficiency of peptide-containing poly(lactide-co-glycolide) microparticles.

    abstract：:The objective of this study was to identify key variables affecting the initial release (burst) and the encapsulation of leuprolide acetate-containing poly(lactide-co-glycolide) (PLGA) microparticles, which were prepared by the cosolvent evaporation method. Adjusting parameters, which affected the PLGA precipitation k...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.06.004

    authors： Luan X,Skupin M,Siepmann J,Bodmeier R

    更新日期：2006-11-06 00:00:00

  • Properties of polyethylene glycol 660 12-hydroxy stearate at a triglyceride/water interface.

    abstract：:This study proposed a method to understand the surfactant role in the first step of the formulation of a novel generation of lipidic nanocapsules. A dynamic rheological protocol was applied using a pendant drop tensiometer in order to determine the interfacial properties of the initial mixture implied in the first for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00144-8

    authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoît JP

    更新日期：2002-08-21 00:00:00

  • Biological properties of low molecular mass peptide dendrimers.

    abstract：:A series of new, low molecular mass, lysine-based peptide dendrimers with varying distribution of cationic and aromatic groups in the structure were synthesized. They expressed antimicrobial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria as well as against fungal p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.10.039

    authors： Klajnert B,Janiszewska J,Urbanczyk-Lipkowska Z,Bryszewska M,Shcharbin D,Labieniec M

    更新日期：2006-02-17 00:00:00

  • Thiolated chitosan: development and in vitro evaluation of an oral delivery system for acyclovir.

    abstract：:The aim of the study was to develop a novel oral delivery system for the efflux pump substrate acyclovir (ACY) utilizing thiolated chitosan as excipient which is capable of inhibiting P-glycoprotein (P-gp). Three chitosan-4-thiobutylamidine (Chito-TBA) conjugates with increasing molecular mass (Chito-9.4kDa-TBA, Chito...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.07.004

    authors： Palmberger TF,Hombach J,Bernkop-Schnürch A

    更新日期：2008-02-04 00:00:00

  • Inhalable liposomal formulation for vasoactive intestinal peptide.

    abstract：:Inhalation of vasoactive intestinal peptide (VIP) was suggested as promising treatment option of various lung diseases like asthma and pulmonary hypertension. However, the medical use of peptides is limited by their short half-life due to rapid enzymatic degradation in the airways. For that reason, we recently develop...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.046

    authors： Hajos F,Stark B,Hensler S,Prassl R,Mosgoeller W

    更新日期：2008-06-05 00:00:00

  • Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate.

    abstract：:The purpose of this study was to investigate solid lipid nanoparticles (SLN) hydrogel for transdermal iontophoretic drug delivery. Triamcinolone acetonide acetate (TAA), a glucocorticoids compound, was employed as the model drug. SLN containing the drug triamcinolone acetonide acetate (TAA-SLN) and their carbopol gel ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.013

    authors： Liu W,Hu M,Liu W,Xue C,Xu H,Yang X

    更新日期：2008-11-19 00:00:00

  • Reformulation of etoposide with solubility-enhancing rubusoside.

    abstract：:Etoposide (ETO), a widely used anti-cancer drug, is constrained by its low aqueous solubility and by side effects from both the drug and its solubilizing excipients. In this study, a recently discovered natural solubilizer rubusoside (RUB) was used to achieve the solubilization of ETO. Dynamic light scattering and fre...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.06.013

    authors： Zhang F,Koh GY,Hollingsworth J,Russo PS,Stout RW,Liu Z

    更新日期：2012-09-15 00:00:00

  • Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin.

    abstract：:A novel thiomer derivative of glycol chitosan (GCS) was synthesized by coupling with thioglycolic acid (TGA) and evaluated for the pulmonary delivery of peptides. Nanoparticles (NPs) based on GCS and GCS-TGA were obtained by the ionic gelation method and demonstrated a particle size in the range of 0.23-0.33 microm wi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.07.001

    authors： Makhlof A,Werle M,Tozuka Y,Takeuchi H

    更新日期：2010-09-15 00:00:00

  • Next generation of buccadhesive excipient: Preactivated carboxymethyl cellulose.

    abstract：AIM:Assessment of preactivated carboxymethyl cellulose as potential excipient for buccal drug delivery. METHODS:Firstly, carboxymethyl cellulose (CMC) and cysteine (SH) were covalently coupled via amide bond formation to obtain thiolated carboxymethyl cellulose (CMC-SH). Further, preactivated carboxymethyl cellulose (...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.012

    authors： Laffleur F,Bacher L,Vanicek S,Menzel C,Muhammad I

    更新日期：2016-03-16 00:00:00

  • Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.

    abstract：:Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis and activation, and although they display effectiveness in s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.006

    authors： Haggag YA,Matchett KB,Dakir el-H,Buchanan P,Osman MA,Elgizawy SA,El-Tanani M,Faheem AM,McCarron PA

    更新日期：2017-04-15 00:00:00

  • Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery.

    abstract：:The present study reports the production and characterization of PEG-coated silica nanoparticles (SiNP-PEG) containing insulin for oral administration. High (PEG 20,000) and low (PEG 6000) PEG molecular weights were used in the preparations. SiNP were produced by sol-gel technology followed by PEG adsorption and chara...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.049

    authors： Andreani T,de Souza AL,Kiill CP,Lorenzón EN,Fangueiro JF,Calpena AC,Chaud MV,Garcia ML,Gremião MP,Silva AM,Souto EB

    更新日期：2014-10-01 00:00:00

  • Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders.

    abstract：:Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248n...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.015

    authors： Visan A,Stan GE,Ristoscu C,Popescu-Pelin G,Sopronyi M,Besleaga C,Luculescu C,Chifiriuc MC,Hussien MD,Marsan O,Kergourlay E,Grossin D,Brouillet F,Mihailescu IN

    更新日期：2016-09-10 00:00:00

  • The effect of ultraviolet radiation on the anti-inflammatory effect of filters.

    abstract：:A certain number of filters have notable anti-inflammatory properties with percentage inhibition of PMA-induced edema in mice at over 70%. The question arose as to whether this effect was likely to continue after UV irradiation. It can be noted that 7 filters retain an equivalent anti-inflammatory effect before and af...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.04.067

    authors： Couteau C,Couteau O,Chauvet C,Paparis E,Coiffard LJ

    更新日期：2013-08-16 00:00:00

  • Effect of the combination of organic and inorganic filters on the Sun Protection Factor (SPF) determined by in vitro method.

    abstract：:This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tes...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.05.047

    authors： El-Boury S,Couteau C,Boulande L,Paparis E,Coiffard LJ

    更新日期：2007-08-01 00:00:00

  • Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing.

    abstract：:An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.04.064

    authors： Razavi SM,Callegari G,Drazer G,Cuitiño AM

    更新日期：2016-06-30 00:00:00

  • Transdermal delivery of duloxetine-sulfobutylether-β-cyclodextrin complex for effective management of depression.

    abstract：:Aim of the study was to reduce the dose and dosing frequency of duloxetine HCl (DXT) by complexation with sulfobutylether-β-cyclodextrin (SBEβCD), an anionic cyclodextrin through permeation enhancement for more effective management of depression. Spray dried inclusion complexes of drug with SBEβCD were prepared and in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.120129

    authors： Kumar R,Sinha VR,Dahiya L,Sarwal A

    更新日期：2021-02-01 00:00:00