Abstract：
:To enhance the medicinal activity of bee venom (BV) acupuncture, bee venom was loaded into biodegradable poly(D,L-lactide-co-glycolide) nanoparticles (BV-PLGA-NPs) by a water-in-oil-in-water-emulsion/solvent-evaporation technique. Rat formalin tests were performed after subcutaneous injection of BV-PLGA-NPs to the Zusanli acupuncture point (ST36) at 0.5, 1, 2, 6, 12, 24, and 48 h before plantar injection of 2% formalin. BV-PLGA-NPs treatment showed comparable analgesic activity to typical BV acupuncture during the late phase, compared with saline-treated controls, and the analgesic effect lasted for 12h. PLGA-encapsulation was also effective in alleviating the edema induced by allergens in bee venom. These results indicate that PLGA-encapsulation provided a more prolonged effect of BV acupuncture treatment, while maintaining a comparable therapeutic effect.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Jeong I,Kim BS,Lee H,Lee KM,Shim I,Kang SK,Yin CS,Hahm DHdoi
10.1016/j.ijpharm.2009.06.034subject
Has Abstractpub_date
2009-10-01 00:00:00pages
62-6issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(09)00428-1journal_volume
380pub_type
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